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PNLDC1 (PARN like ribonuclease domain containing exonuclease 1)

Identity

Alias (NCBI)HsPNLDC1
Trimmer
HGNC (Hugo) PNLDC1
HGNC Alias symbFLJ40240
dJ195P10.2
Trimmer
HGNC Previous namepoly(A)-specific ribonuclease (PARN)-like domain containing 1
 PARN like, ribonuclease domain containing 1
LocusID (NCBI) 154197
Atlas_Id 57192
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 159800249 and ends at 159820704 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PNLDC1   21185
Cards
Entrez_Gene (NCBI)PNLDC1    PARN like ribonuclease domain containing exonuclease 1
AliasesHsPNLDC1; Trimmer
GeneCards (Weizmann)PNLDC1
Ensembl hg19 (Hinxton)ENSG00000146453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146453 [Gene_View]  ENSG00000146453 [Sequence]  chr6:159800249-159820704 [Contig_View]  PNLDC1 [Vega]
ICGC DataPortalENSG00000146453
TCGA cBioPortalPNLDC1
AceView (NCBI)PNLDC1
Genatlas (Paris)PNLDC1
SOURCE (Princeton)PNLDC1
Genetics Home Reference (NIH)PNLDC1
Genomic and cartography
GoldenPath hg38 (UCSC)PNLDC1  -     chr6:159800249-159820704 +  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNLDC1  -     6q25.3   [Description]    (hg19-Feb_2009)
GoldenPathPNLDC1 - 6q25.3 [CytoView hg19]  PNLDC1 - 6q25.3 [CytoView hg38]
ImmunoBaseENSG00000146453
Genome Data Viewer NCBIPNLDC1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK093139 AK097559 BC112246 BM666663
RefSeq transcript (Entrez)NM_001271862 NM_173516
Consensus coding sequences : CCDS (NCBI)PNLDC1
Gene ExpressionPNLDC1 [ NCBI-GEO ]   PNLDC1 [ EBI - ARRAY_EXPRESS ]   PNLDC1 [ SEEK ]   PNLDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PNLDC1 [ Firebrowse - Broad ]
GenevisibleExpression of PNLDC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154197
GTEX Portal (Tissue expression)PNLDC1
Human Protein AtlasENSG00000146453-PNLDC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NA58   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NA58  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NA58
PhosPhoSitePlusQ8NA58
Domains : Interpro (EBI)R3H_dom_sf    RNase_CAF1    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)CAF1 (PF04857)   
Domain families : Pfam (NCBI)pfam04857   
Conserved Domain (NCBI)PNLDC1
SuperfamilyQ8NA58
AlphaFold pdb e-kbQ8NA58   
Human Protein Atlas [tissue]ENSG00000146453-PNLDC1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q8NA58
IntAct (EBI)Q8NA58
BioGRIDPNLDC1
STRING (EMBL)PNLDC1
ZODIACPNLDC1
Ontologies - Pathways
QuickGOQ8NA58
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  blastocyst formation  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  blastocyst formation  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
NDEx NetworkPNLDC1
Atlas of Cancer Signalling NetworkPNLDC1
Wikipedia pathwaysPNLDC1
Orthology - Evolution
OrthoDB154197
GeneTree (enSembl)ENSG00000146453
Phylogenetic Trees/Animal Genes : TreeFamPNLDC1
Homologs : HomoloGenePNLDC1
Homology/Alignments : Family Browser (UCSC)PNLDC1
Gene fusions - Rearrangements
Fusion : QuiverPNLDC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNLDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNLDC1
dbVarPNLDC1
ClinVarPNLDC1
MonarchPNLDC1
1000_GenomesPNLDC1 
Exome Variant ServerPNLDC1
GNOMAD BrowserENSG00000146453
Varsome BrowserPNLDC1
ACMGPNLDC1 variants
VarityQ8NA58
Genomic Variants (DGV)PNLDC1 [DGVbeta]
DECIPHERPNLDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNLDC1 
Mutations
ICGC Data PortalPNLDC1 
TCGA Data PortalPNLDC1 
Broad Tumor PortalPNLDC1
OASIS PortalPNLDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNLDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPNLDC1
Mutations and Diseases : HGMDPNLDC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPNLDC1
DgiDB (Drug Gene Interaction Database)PNLDC1
DoCM (Curated mutations)PNLDC1
CIViC (Clinical Interpretations of Variants in Cancer)PNLDC1
Cancer3DPNLDC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPNLDC1
MedgenPNLDC1
Genetic Testing Registry PNLDC1
NextProtQ8NA58 [Medical]
GENETestsPNLDC1
Target ValidationPNLDC1
Huge Navigator PNLDC1 [HugePedia]
ClinGenPNLDC1
Clinical trials, drugs, therapy
MyCancerGenomePNLDC1
Protein Interactions : CTDPNLDC1
Pharm GKB GenePA134892245
PharosQ8NA58
Clinical trialPNLDC1
Miscellaneous
canSAR (ICR)PNLDC1
HarmonizomePNLDC1
DataMed IndexPNLDC1
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPNLDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:55 CEST 2021

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