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PNLDC1 (PARN like, ribonuclease domain containing 1)

Identity

Other aliasHsPNLDC1
HGNC (Hugo) PNLDC1
LocusID (NCBI) 154197
Atlas_Id 57192
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 159800249 and ends at 159820704 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PNLDC1   21185
Cards
Entrez_Gene (NCBI)PNLDC1  154197  PARN like, ribonuclease domain containing 1
AliasesHsPNLDC1
GeneCards (Weizmann)PNLDC1
Ensembl hg19 (Hinxton)ENSG00000146453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146453 [Gene_View]  ENSG00000146453 [Sequence]  chr6:159800249-159820704 [Contig_View]  PNLDC1 [Vega]
ICGC DataPortalENSG00000146453
TCGA cBioPortalPNLDC1
AceView (NCBI)PNLDC1
Genatlas (Paris)PNLDC1
WikiGenes154197
SOURCE (Princeton)PNLDC1
Genetics Home Reference (NIH)PNLDC1
Genomic and cartography
GoldenPath hg38 (UCSC)PNLDC1  -     chr6:159800249-159820704 +  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNLDC1  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblPNLDC1 - 6q25.3 [CytoView hg19]  PNLDC1 - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBIPNLDC1 [Mapview hg19]  PNLDC1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK093139 AK097559 BC112246 BM666663
RefSeq transcript (Entrez)NM_001271862 NM_173516
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PNLDC1
Cluster EST : UnigeneHs.349077 [ NCBI ]
CGAP (NCI)Hs.349077
Alternative Splicing GalleryENSG00000146453
Gene ExpressionPNLDC1 [ NCBI-GEO ]   PNLDC1 [ EBI - ARRAY_EXPRESS ]   PNLDC1 [ SEEK ]   PNLDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PNLDC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154197
GTEX Portal (Tissue expression)PNLDC1
Human Protein AtlasENSG00000146453-PNLDC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NA58   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NA58  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NA58
Splice isoforms : SwissVarQ8NA58
PhosPhoSitePlusQ8NA58
Domains : Interpro (EBI)R3H_dom_sf    RNase_CAF1    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)CAF1 (PF04857)   
Domain families : Pfam (NCBI)pfam04857   
Conserved Domain (NCBI)PNLDC1
DMDM Disease mutations154197
Blocks (Seattle)PNLDC1
SuperfamilyQ8NA58
Human Protein Atlas [tissue]ENSG00000146453-PNLDC1 [tissue]
Peptide AtlasQ8NA58
IPIIPI00167911   IPI00797928   
Protein Interaction databases
DIP (DOE-UCLA)Q8NA58
IntAct (EBI)Q8NA58
FunCoupENSG00000146453
BioGRIDPNLDC1
STRING (EMBL)PNLDC1
ZODIACPNLDC1
Ontologies - Pathways
QuickGOQ8NA58
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
NDEx NetworkPNLDC1
Atlas of Cancer Signalling NetworkPNLDC1
Wikipedia pathwaysPNLDC1
Orthology - Evolution
OrthoDB154197
GeneTree (enSembl)ENSG00000146453
Phylogenetic Trees/Animal Genes : TreeFamPNLDC1
HOVERGENQ8NA58
HOGENOMQ8NA58
Homologs : HomoloGenePNLDC1
Homology/Alignments : Family Browser (UCSC)PNLDC1
Gene fusions - Rearrangements
Fusion : QuiverPNLDC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNLDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNLDC1
dbVarPNLDC1
ClinVarPNLDC1
1000_GenomesPNLDC1 
Exome Variant ServerPNLDC1
ExAC (Exome Aggregation Consortium)ENSG00000146453
GNOMAD BrowserENSG00000146453
Varsome BrowserPNLDC1
Genetic variants : HAPMAP154197
Genomic Variants (DGV)PNLDC1 [DGVbeta]
DECIPHERPNLDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNLDC1 
Mutations
ICGC Data PortalPNLDC1 
TCGA Data PortalPNLDC1 
Broad Tumor PortalPNLDC1
OASIS PortalPNLDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNLDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPNLDC1
BioMutasearch PNLDC1
DgiDB (Drug Gene Interaction Database)PNLDC1
DoCM (Curated mutations)PNLDC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PNLDC1 (select a term)
intoGenPNLDC1
Cancer3DPNLDC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPNLDC1
MedgenPNLDC1
Genetic Testing Registry PNLDC1
NextProtQ8NA58 [Medical]
TSGene154197
GENETestsPNLDC1
Target ValidationPNLDC1
Huge Navigator PNLDC1 [HugePedia]
snp3D : Map Gene to Disease154197
BioCentury BCIQPNLDC1
ClinGenPNLDC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD154197
Chemical/Pharm GKB GenePA134892245
Clinical trialPNLDC1
Miscellaneous
canSAR (ICR)PNLDC1 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePNLDC1
EVEXPNLDC1
GoPubMedPNLDC1
iHOPPNLDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:30:56 CET 2018

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