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PNLIP (pancreatic lipase)

Identity

Alias (NCBI)PL
PNLIPD
PTL
HGNC (Hugo) PNLIP
HGNC Alias symbPL
HGNC Alias nametriacylglycerol lipase
LocusID (NCBI) 5406
Atlas_Id 52946
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 116545931 and ends at 116567855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PNLIP (10q25.3) / CPB1 (3q24)PNLIP (10q25.3) / PNLIP (10q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PNLIP   9155
Cards
Entrez_Gene (NCBI)PNLIP    pancreatic lipase
AliasesPL; PNLIPD; PTL
GeneCards (Weizmann)PNLIP
Ensembl hg19 (Hinxton)ENSG00000175535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175535 [Gene_View]  ENSG00000175535 [Sequence]  chr10:116545931-116567855 [Contig_View]  PNLIP [Vega]
ICGC DataPortalENSG00000175535
TCGA cBioPortalPNLIP
AceView (NCBI)PNLIP
Genatlas (Paris)PNLIP
SOURCE (Princeton)PNLIP
Genetics Home Reference (NIH)PNLIP
Genomic and cartography
GoldenPath hg38 (UCSC)PNLIP  -     chr10:116545931-116567855 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNLIP  -     10q25.3   [Description]    (hg19-Feb_2009)
GoldenPathPNLIP - 10q25.3 [CytoView hg19]  PNLIP - 10q25.3 [CytoView hg38]
ImmunoBaseENSG00000175535
Genome Data Viewer NCBIPNLIP [Mapview hg19]  
OMIM246600   614338   
Gene and transcription
Genbank (Entrez)A24059 AK313941 AW873921 BC007025 BC014309
RefSeq transcript (Entrez)NM_000936
Consensus coding sequences : CCDS (NCBI)PNLIP
Gene ExpressionPNLIP [ NCBI-GEO ]   PNLIP [ EBI - ARRAY_EXPRESS ]   PNLIP [ SEEK ]   PNLIP [ MEM ]
Gene Expression Viewer (FireBrowse)PNLIP [ Firebrowse - Broad ]
GenevisibleExpression of PNLIP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5406
GTEX Portal (Tissue expression)PNLIP
Human Protein AtlasENSG00000175535-PNLIP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16233   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16233
PhosPhoSitePlusP16233
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)AB_hydrolase    Lipase/vitellogenin    Lipase_LIPH    Lipase_N    Lipase_panc    PLAT/LH2_dom    PLAT/LH2_dom_sf    TAG_lipase   
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)PNLIP
PDB (RSDB)1GPL    1LPA    1LPB    1N8S   
PDB Europe1GPL    1LPA    1LPB    1N8S   
PDB (PDBSum)1GPL    1LPA    1LPB    1N8S   
PDB (IMB)1GPL    1LPA    1LPB    1N8S   
Structural Biology KnowledgeBase1GPL    1LPA    1LPB    1N8S   
SCOP (Structural Classification of Proteins)1GPL    1LPA    1LPB    1N8S   
CATH (Classification of proteins structures)1GPL    1LPA    1LPB    1N8S   
SuperfamilyP16233
AlphaFold pdb e-kbP16233   
Human Protein Atlas [tissue]ENSG00000175535-PNLIP [tissue]
HPRD02005
Protein Interaction databases
DIP (DOE-UCLA)P16233
IntAct (EBI)P16233
BioGRIDPNLIP
STRING (EMBL)PNLIP
ZODIACPNLIP
Ontologies - Pathways
QuickGOP16233
Ontology : AmiGOretinoid metabolic process  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  extracellular space  lipid metabolic process  lipid catabolic process  lipase activity  lipase activity  intestinal cholesterol absorption  retinol metabolic process  lipid digestion  metal ion binding  all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity  positive regulation of triglyceride lipase activity  
Ontology : EGO-EBIretinoid metabolic process  triglyceride lipase activity  triglyceride lipase activity  extracellular region  extracellular space  extracellular space  lipid metabolic process  lipid catabolic process  lipase activity  lipase activity  intestinal cholesterol absorption  retinol metabolic process  lipid digestion  metal ion binding  all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity  positive regulation of triglyceride lipase activity  
Pathways : KEGGGlycerolipid metabolism    Pancreatic secretion    Fat digestion and absorption    Vitamin digestion and absorption   
NDEx NetworkPNLIP
Atlas of Cancer Signalling NetworkPNLIP
Wikipedia pathwaysPNLIP
Orthology - Evolution
OrthoDB5406
GeneTree (enSembl)ENSG00000175535
Phylogenetic Trees/Animal Genes : TreeFamPNLIP
Homologs : HomoloGenePNLIP
Homology/Alignments : Family Browser (UCSC)PNLIP
Gene fusions - Rearrangements
Fusion : QuiverPNLIP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNLIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNLIP
dbVarPNLIP
ClinVarPNLIP
MonarchPNLIP
1000_GenomesPNLIP 
Exome Variant ServerPNLIP
GNOMAD BrowserENSG00000175535
Varsome BrowserPNLIP
ACMGPNLIP variants
VarityP16233
Genomic Variants (DGV)PNLIP [DGVbeta]
DECIPHERPNLIP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNLIP 
Mutations
ICGC Data PortalPNLIP 
TCGA Data PortalPNLIP 
Broad Tumor PortalPNLIP
OASIS PortalPNLIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNLIP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPNLIP
Mutations and Diseases : HGMDPNLIP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPNLIP
DgiDB (Drug Gene Interaction Database)PNLIP
DoCM (Curated mutations)PNLIP
CIViC (Clinical Interpretations of Variants in Cancer)PNLIP
Cancer3DPNLIP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM246600    614338   
Orphanet21341   
DisGeNETPNLIP
MedgenPNLIP
Genetic Testing Registry PNLIP
NextProtP16233 [Medical]
GENETestsPNLIP
Target ValidationPNLIP
Huge Navigator PNLIP [HugePedia]
ClinGenPNLIP
Clinical trials, drugs, therapy
MyCancerGenomePNLIP
Protein Interactions : CTDPNLIP
Pharm GKB GenePA33478
PharosP16233
Clinical trialPNLIP
Miscellaneous
canSAR (ICR)PNLIP
HarmonizomePNLIP
DataMed IndexPNLIP
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPNLIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:56 CEST 2021

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