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PNLIP (pancreatic lipase)

Identity

Alias_symbol (synonym)PL
Other aliasPNLIPD
PTL
HGNC (Hugo) PNLIP
LocusID (NCBI) 5406
Atlas_Id 52946
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 116545924 and ends at 116567858 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PNLIP (10q25.3) / CPB1 (3q24)PNLIP (10q25.3) / PNLIP (10q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PNLIP   9155
Cards
Entrez_Gene (NCBI)PNLIP  5406  pancreatic lipase
AliasesPL; PNLIPD; PTL
GeneCards (Weizmann)PNLIP
Ensembl hg19 (Hinxton)ENSG00000175535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175535 [Gene_View]  chr10:116545924-116567858 [Contig_View]  PNLIP [Vega]
ICGC DataPortalENSG00000175535
TCGA cBioPortalPNLIP
AceView (NCBI)PNLIP
Genatlas (Paris)PNLIP
WikiGenes5406
SOURCE (Princeton)PNLIP
Genetics Home Reference (NIH)PNLIP
Genomic and cartography
GoldenPath hg38 (UCSC)PNLIP  -     chr10:116545924-116567858 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNLIP  -     10q25.3   [Description]    (hg19-Feb_2009)
EnsemblPNLIP - 10q25.3 [CytoView hg19]  PNLIP - 10q25.3 [CytoView hg38]
Mapping of homologs : NCBIPNLIP [Mapview hg19]  PNLIP [Mapview hg38]
OMIM246600   614338   
Gene and transcription
Genbank (Entrez)A24059 AK313941 AW873921 BC007025 BC014309
RefSeq transcript (Entrez)NM_000936
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PNLIP
Cluster EST : UnigeneHs.501135 [ NCBI ]
CGAP (NCI)Hs.501135
Alternative Splicing GalleryENSG00000175535
Gene ExpressionPNLIP [ NCBI-GEO ]   PNLIP [ EBI - ARRAY_EXPRESS ]   PNLIP [ SEEK ]   PNLIP [ MEM ]
Gene Expression Viewer (FireBrowse)PNLIP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5406
GTEX Portal (Tissue expression)PNLIP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16233   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16233
Splice isoforms : SwissVarP16233
Catalytic activity : Enzyme3.1.1.3 [ Enzyme-Expasy ]   3.1.1.33.1.1.3 [ IntEnz-EBI ]   3.1.1.3 [ BRENDA ]   3.1.1.3 [ KEGG ]   
PhosPhoSitePlusP16233
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)AB_hydrolase    Lipase/vitellogenin    Lipase_LIPH    Lipase_N    Lipase_panc    PLAT/LH2_dom    TAG_lipase   
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)PNLIP
DMDM Disease mutations5406
Blocks (Seattle)PNLIP
PDB (SRS)1LPA    1LPB    1N8S   
PDB (PDBSum)1LPA    1LPB    1N8S   
PDB (IMB)1LPA    1LPB    1N8S   
PDB (RSDB)1LPA    1LPB    1N8S   
Structural Biology KnowledgeBase1LPA    1LPB    1N8S   
SCOP (Structural Classification of Proteins)1LPA    1LPB    1N8S   
CATH (Classification of proteins structures)1LPA    1LPB    1N8S   
SuperfamilyP16233
Human Protein AtlasENSG00000175535
Peptide AtlasP16233
HPRD02005
IPIIPI00027720   
Protein Interaction databases
DIP (DOE-UCLA)P16233
IntAct (EBI)P16233
FunCoupENSG00000175535
BioGRIDPNLIP
STRING (EMBL)PNLIP
ZODIACPNLIP
Ontologies - Pathways
QuickGOP16233
Ontology : AmiGOretinoid metabolic process  triglyceride lipase activity  extracellular region  lipid catabolic process  intestinal cholesterol absorption  lipid digestion  metal ion binding  positive regulation of triglyceride lipase activity  
Ontology : EGO-EBIretinoid metabolic process  triglyceride lipase activity  extracellular region  lipid catabolic process  intestinal cholesterol absorption  lipid digestion  metal ion binding  positive regulation of triglyceride lipase activity  
Pathways : KEGGGlycerolipid metabolism    Pancreatic secretion    Fat digestion and absorption    Vitamin digestion and absorption   
NDEx NetworkPNLIP
Atlas of Cancer Signalling NetworkPNLIP
Wikipedia pathwaysPNLIP
Orthology - Evolution
OrthoDB5406
GeneTree (enSembl)ENSG00000175535
Phylogenetic Trees/Animal Genes : TreeFamPNLIP
HOVERGENP16233
HOGENOMP16233
Homologs : HomoloGenePNLIP
Homology/Alignments : Family Browser (UCSC)PNLIP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNLIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNLIP
dbVarPNLIP
ClinVarPNLIP
1000_GenomesPNLIP 
Exome Variant ServerPNLIP
ExAC (Exome Aggregation Consortium)PNLIP (select the gene name)
Genetic variants : HAPMAP5406
Genomic Variants (DGV)PNLIP [DGVbeta]
DECIPHERPNLIP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNLIP 
Mutations
ICGC Data PortalPNLIP 
TCGA Data PortalPNLIP 
Broad Tumor PortalPNLIP
OASIS PortalPNLIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNLIP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPNLIP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PNLIP
DgiDB (Drug Gene Interaction Database)PNLIP
DoCM (Curated mutations)PNLIP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PNLIP (select a term)
intoGenPNLIP
Cancer3DPNLIP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM246600    614338   
Orphanet21341   
MedgenPNLIP
Genetic Testing Registry PNLIP
NextProtP16233 [Medical]
TSGene5406
GENETestsPNLIP
Huge Navigator PNLIP [HugePedia]
snp3D : Map Gene to Disease5406
BioCentury BCIQPNLIP
ClinGenPNLIP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5406
Chemical/Pharm GKB GenePA33478
Clinical trialPNLIP
Miscellaneous
canSAR (ICR)PNLIP (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePNLIP
EVEXPNLIP
GoPubMedPNLIP
iHOPPNLIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:50 CEST 2017

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