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PNMT (phenylethanolamine N-methyltransferase)

Identity

Alias_namesPENT
Other aliasPNMTase
HGNC (Hugo) PNMT
LocusID (NCBI) 5409
Atlas_Id 46493
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 37824706 and ends at 37826728 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASTN2 (9q33.1) / PNMT (17q12)ASTN2 9q33.1 / PNMT 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PNMT   9160
Cards
Entrez_Gene (NCBI)PNMT  5409  phenylethanolamine N-methyltransferase
AliasesPENT; PNMTase
GeneCards (Weizmann)PNMT
Ensembl hg19 (Hinxton)ENSG00000141744 [Gene_View]  chr17:37824706-37826728 [Contig_View]  PNMT [Vega]
Ensembl hg38 (Hinxton)ENSG00000141744 [Gene_View]  chr17:37824706-37826728 [Contig_View]  PNMT [Vega]
ICGC DataPortalENSG00000141744
TCGA cBioPortalPNMT
AceView (NCBI)PNMT
Genatlas (Paris)PNMT
WikiGenes5409
SOURCE (Princeton)PNMT
Genetics Home Reference (NIH)PNMT
Genomic and cartography
GoldenPath hg19 (UCSC)PNMT  -     chr17:37824706-37826728 +  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PNMT  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblPNMT - 17q12 [CytoView hg19]  PNMT - 17q12 [CytoView hg38]
Mapping of homologs : NCBIPNMT [Mapview hg19]  PNMT [Mapview hg38]
OMIM171190   
Gene and transcription
Genbank (Entrez)BC037246 BG394800 CR541815 EU832114 EU832208
RefSeq transcript (Entrez)NM_002686
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_042278 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)PNMT
Cluster EST : UnigeneHs.1892 [ NCBI ]
CGAP (NCI)Hs.1892
Alternative Splicing GalleryENSG00000141744
Gene ExpressionPNMT [ NCBI-GEO ]   PNMT [ EBI - ARRAY_EXPRESS ]   PNMT [ SEEK ]   PNMT [ MEM ]
Gene Expression Viewer (FireBrowse)PNMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5409
GTEX Portal (Tissue expression)PNMT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11086
Splice isoforms : SwissVarP11086
Catalytic activity : Enzyme2.1.1.28 [ Enzyme-Expasy ]   2.1.1.282.1.1.28 [ IntEnz-EBI ]   2.1.1.28 [ BRENDA ]   2.1.1.28 [ KEGG ]   
PhosPhoSitePlusP11086
Domaine pattern : Prosite (Expaxy)NNMT_PNMT_TEMT (PS01100)    SAM_MT_NNMT_PNMT_TEMT (PS51681)   
Domains : Interpro (EBI)NNMT/PNMT/TEMT_CS    NNMT_TEMT_trans    SAM-dependent_MTases   
Domain families : Pfam (Sanger)NNMT_PNMT_TEMT (PF01234)   
Domain families : Pfam (NCBI)pfam01234   
Conserved Domain (NCBI)PNMT
DMDM Disease mutations5409
Blocks (Seattle)PNMT
PDB (SRS)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
PDB (PDBSum)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
PDB (IMB)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
PDB (RSDB)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
Structural Biology KnowledgeBase1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
SCOP (Structural Classification of Proteins)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
CATH (Classification of proteins structures)1HNN    1N7I    1N7J    1YZ3    2AN3    2AN4    2AN5    2G70    2G71    2G72    2G8N    2OBF    2ONY    2ONZ    2OPB    3HCA    3HCB    3HCC    3HCD    3HCE    3HCF    3KPJ    3KPU    3KPV    3KPW    3KPY    3KQM    3KQO    3KQP    3KQQ    3KQS    3KQT    3KQV    3KQW    3KQY    3KR0    3KR1    3KR2    4DM3    4MIK    4MQ4   
SuperfamilyP11086
Human Protein AtlasENSG00000141744
Peptide AtlasP11086
HPRD07176
IPIIPI00796949   IPI00797601   
Protein Interaction databases
DIP (DOE-UCLA)P11086
IntAct (EBI)P11086
FunCoupENSG00000141744
BioGRIDPNMT
STRING (EMBL)PNMT
ZODIACPNMT
Ontologies - Pathways
QuickGOP11086
Ontology : AmiGOphenylethanolamine N-methyltransferase activity  cytosol  methylation  epinephrine biosynthetic process  catecholamine biosynthetic process  
Ontology : EGO-EBIphenylethanolamine N-methyltransferase activity  cytosol  methylation  epinephrine biosynthetic process  catecholamine biosynthetic process  
Pathways : KEGGTyrosine metabolism   
NDEx NetworkPNMT
Atlas of Cancer Signalling NetworkPNMT
Wikipedia pathwaysPNMT
Orthology - Evolution
OrthoDB5409
GeneTree (enSembl)ENSG00000141744
Phylogenetic Trees/Animal Genes : TreeFamPNMT
HOVERGENP11086
HOGENOMP11086
Homologs : HomoloGenePNMT
Homology/Alignments : Family Browser (UCSC)PNMT
Gene fusions - Rearrangements
Fusion : MitelmanASTN2/PNMT [9q33.1/17q12]  [t(9;17)(q33;q12)]  
Fusion: TCGAASTN2 9q33.1 PNMT 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNMT
dbVarPNMT
ClinVarPNMT
1000_GenomesPNMT 
Exome Variant ServerPNMT
ExAC (Exome Aggregation Consortium)PNMT (select the gene name)
Genetic variants : HAPMAP5409
Genomic Variants (DGV)PNMT [DGVbeta]
DECIPHER (Syndromes)17:37824706-37826728  ENSG00000141744
CONAN: Copy Number AnalysisPNMT 
Mutations
ICGC Data PortalPNMT 
TCGA Data PortalPNMT 
Broad Tumor PortalPNMT
OASIS PortalPNMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPNMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PNMT
DgiDB (Drug Gene Interaction Database)PNMT
DoCM (Curated mutations)PNMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PNMT (select a term)
intoGenPNMT
Cancer3DPNMT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171190   
Orphanet
MedgenPNMT
Genetic Testing Registry PNMT
NextProtP11086 [Medical]
TSGene5409
GENETestsPNMT
Huge Navigator PNMT [HugePedia]
snp3D : Map Gene to Disease5409
BioCentury BCIQPNMT
ClinGenPNMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5409
Chemical/Pharm GKB GenePA274
Clinical trialPNMT
Miscellaneous
canSAR (ICR)PNMT (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePNMT
EVEXPNMT
GoPubMedPNMT
iHOPPNMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:54 CEST 2017

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