Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PNOC (prepronociceptin)

Identity

Alias_symbol (synonym)PPNOC
N/OFQ
NOP
Other aliasOFQ
ppN/OFQ
HGNC (Hugo) PNOC
LocusID (NCBI) 5368
Atlas_Id 53968
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 28338648 and ends at 28343354 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIF13B (8p12) / PNOC (8p21.1)PDLIM3 (4q35.1) / PNOC (8p21.1)RHOBTB2 (8p21.3) / PNOC (8p21.1)
KIF13B 8p12 / PNOC 8p21.1RHOBTB2 8p21.3 / PNOC 8p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PNOC   9163
Cards
Entrez_Gene (NCBI)PNOC  5368  prepronociceptin
AliasesN/OFQ; NOP; OFQ; PPNOC; 
ppN/OFQ
GeneCards (Weizmann)PNOC
Ensembl hg19 (Hinxton)ENSG00000168081 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168081 [Gene_View]  chr8:28338648-28343354 [Contig_View]  PNOC [Vega]
ICGC DataPortalENSG00000168081
TCGA cBioPortalPNOC
AceView (NCBI)PNOC
Genatlas (Paris)PNOC
WikiGenes5368
SOURCE (Princeton)PNOC
Genetics Home Reference (NIH)PNOC
Genomic and cartography
GoldenPath hg38 (UCSC)PNOC  -     chr8:28338648-28343354 +  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNOC  -     8p21.1   [Description]    (hg19-Feb_2009)
EnsemblPNOC - 8p21.1 [CytoView hg19]  PNOC - 8p21.1 [CytoView hg38]
Mapping of homologs : NCBIPNOC [Mapview hg19]  PNOC [Mapview hg38]
OMIM601459   
Gene and transcription
Genbank (Entrez)AK289633 AK301456 AY335948 BC034758 BF976583
RefSeq transcript (Entrez)NM_001284244 NM_006228
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PNOC
Cluster EST : UnigeneHs.88218 [ NCBI ]
CGAP (NCI)Hs.88218
Alternative Splicing GalleryENSG00000168081
Gene ExpressionPNOC [ NCBI-GEO ]   PNOC [ EBI - ARRAY_EXPRESS ]   PNOC [ SEEK ]   PNOC [ MEM ]
Gene Expression Viewer (FireBrowse)PNOC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5368
GTEX Portal (Tissue expression)PNOC
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13519
Splice isoforms : SwissVarQ13519
PhosPhoSitePlusQ13519
Domaine pattern : Prosite (Expaxy)OPIOIDS_PRECURSOR (PS01252)   
Domains : Interpro (EBI)Nociceptin    Opioid_neupept   
Domain families : Pfam (Sanger)Opiods_neuropep (PF01160)   
Domain families : Pfam (NCBI)pfam01160   
Conserved Domain (NCBI)PNOC
DMDM Disease mutations5368
Blocks (Seattle)PNOC
SuperfamilyQ13519
Human Protein AtlasENSG00000168081
Peptide AtlasQ13519
HPRD03268
IPIIPI00013701   IPI00985086   IPI00789117   
Protein Interaction databases
DIP (DOE-UCLA)Q13519
IntAct (EBI)Q13519
FunCoupENSG00000168081
BioGRIDPNOC
STRING (EMBL)PNOC
ZODIACPNOC
Ontologies - Pathways
QuickGOQ13519
Ontology : AmiGOopioid peptide activity  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  neuropeptide signaling pathway  chemical synaptic transmission  female pregnancy  sensory perception  dendrite  opioid receptor binding  neuronal cell body  axon terminus  
Ontology : EGO-EBIopioid peptide activity  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  neuropeptide signaling pathway  chemical synaptic transmission  female pregnancy  sensory perception  dendrite  opioid receptor binding  neuronal cell body  axon terminus  
NDEx NetworkPNOC
Atlas of Cancer Signalling NetworkPNOC
Wikipedia pathwaysPNOC
Orthology - Evolution
OrthoDB5368
GeneTree (enSembl)ENSG00000168081
Phylogenetic Trees/Animal Genes : TreeFamPNOC
HOVERGENQ13519
HOGENOMQ13519
Homologs : HomoloGenePNOC
Homology/Alignments : Family Browser (UCSC)PNOC
Gene fusions - Rearrangements
Fusion : MitelmanKIF13B/PNOC [8p12/8p21.1]  [t(8;8)(p12;p21)]  
Fusion : MitelmanRHOBTB2/PNOC [8p21.3/8p21.1]  [t(8;8)(p21;p21)]  
Fusion: TCGAKIF13B 8p12 PNOC 8p21.1 PRAD
Fusion: TCGARHOBTB2 8p21.3 PNOC 8p21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNOC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNOC
dbVarPNOC
ClinVarPNOC
1000_GenomesPNOC 
Exome Variant ServerPNOC
ExAC (Exome Aggregation Consortium)PNOC (select the gene name)
Genetic variants : HAPMAP5368
Genomic Variants (DGV)PNOC [DGVbeta]
DECIPHERPNOC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNOC 
Mutations
ICGC Data PortalPNOC 
TCGA Data PortalPNOC 
Broad Tumor PortalPNOC
OASIS PortalPNOC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNOC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPNOC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PNOC
DgiDB (Drug Gene Interaction Database)PNOC
DoCM (Curated mutations)PNOC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PNOC (select a term)
intoGenPNOC
Cancer3DPNOC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601459   
Orphanet
MedgenPNOC
Genetic Testing Registry PNOC
NextProtQ13519 [Medical]
TSGene5368
GENETestsPNOC
Huge Navigator PNOC [HugePedia]
snp3D : Map Gene to Disease5368
BioCentury BCIQPNOC
ClinGenPNOC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5368
Chemical/Pharm GKB GenePA33485
Clinical trialPNOC
Miscellaneous
canSAR (ICR)PNOC (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePNOC
EVEXPNOC
GoPubMedPNOC
iHOPPNOC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:52 CEST 2017

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