Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PNOC (prepronociceptin)

Identity

Alias (NCBI)N/OFQ
NOP
OFQ
PPNOC
ppN/OFQ
HGNC (Hugo) PNOC
HGNC Alias symbPPNOC
N/OFQ
NOP
HGNC Alias namenocistatin
 orphanin FQ
LocusID (NCBI) 5368
Atlas_Id 53968
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 28317268 and ends at 28343351 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIF13B (8p12)::PNOC (8p21.1)PDLIM3 (4q35.1)::PNOC (8p21.1)RHOBTB2 (8p21.3)::PNOC (8p21.1)
KIF13B 8p12::PNOC 8p21.1RHOBTB2 8p21.3::PNOC 8p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PNOC   9163
Cards
Entrez_Gene (NCBI)PNOC    prepronociceptin
AliasesN/OFQ; NOP; OFQ; PPNOC; 
ppN/OFQ
GeneCards (Weizmann)PNOC
Ensembl hg19 (Hinxton)ENSG00000168081 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168081 [Gene_View]  ENSG00000168081 [Sequence]  chr8:28317268-28343351 [Contig_View]  PNOC [Vega]
ICGC DataPortalENSG00000168081
TCGA cBioPortalPNOC
AceView (NCBI)PNOC
Genatlas (Paris)PNOC
SOURCE (Princeton)PNOC
Genetics Home Reference (NIH)PNOC
Genomic and cartography
GoldenPath hg38 (UCSC)PNOC  -     chr8:28317268-28343351 +  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PNOC  -     8p21.1   [Description]    (hg19-Feb_2009)
GoldenPathPNOC - 8p21.1 [CytoView hg19]  PNOC - 8p21.1 [CytoView hg38]
ImmunoBaseENSG00000168081
Genome Data Viewer NCBIPNOC [Mapview hg19]  
OMIM601459   
Gene and transcription
Genbank (Entrez)AK289633 AK301456 AY335948 BC034758 BF976583
RefSeq transcript (Entrez)NM_001284244 NM_006228
Consensus coding sequences : CCDS (NCBI)PNOC
Gene ExpressionPNOC [ NCBI-GEO ]   PNOC [ EBI - ARRAY_EXPRESS ]   PNOC [ SEEK ]   PNOC [ MEM ]
Gene Expression Viewer (FireBrowse)PNOC [ Firebrowse - Broad ]
GenevisibleExpression of PNOC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5368
GTEX Portal (Tissue expression)PNOC
Human Protein AtlasENSG00000168081-PNOC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13519
PhosPhoSitePlusQ13519
Domaine pattern : Prosite (Expaxy)OPIOIDS_PRECURSOR (PS01252)   
Domains : Interpro (EBI)Nociceptin    Opioid_neupept   
Domain families : Pfam (Sanger)Opiods_neuropep (PF01160)   
Domain families : Pfam (NCBI)pfam01160   
Conserved Domain (NCBI)PNOC
SuperfamilyQ13519
AlphaFold pdb e-kbQ13519   
Human Protein Atlas [tissue]ENSG00000168081-PNOC [tissue]
HPRD03268
Protein Interaction databases
DIP (DOE-UCLA)Q13519
IntAct (EBI)Q13519
BioGRIDPNOC
STRING (EMBL)PNOC
ZODIACPNOC
Ontologies - Pathways
QuickGOQ13519
Ontology : AmiGOopioid peptide activity  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  female pregnancy  sensory perception  dendrite  opioid receptor binding  neuronal cell body  axon terminus  
Ontology : EGO-EBIopioid peptide activity  neuropeptide hormone activity  extracellular region  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  female pregnancy  sensory perception  dendrite  opioid receptor binding  neuronal cell body  axon terminus  
NDEx NetworkPNOC
Atlas of Cancer Signalling NetworkPNOC
Wikipedia pathwaysPNOC
Orthology - Evolution
OrthoDB5368
GeneTree (enSembl)ENSG00000168081
Phylogenetic Trees/Animal Genes : TreeFamPNOC
Homologs : HomoloGenePNOC
Homology/Alignments : Family Browser (UCSC)PNOC
Gene fusions - Rearrangements
Fusion : MitelmanKIF13B::PNOC [8p12/8p21.1]  
Fusion : MitelmanRHOBTB2::PNOC [8p21.3/8p21.1]  
Fusion : QuiverPNOC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPNOC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNOC
dbVarPNOC
ClinVarPNOC
MonarchPNOC
1000_GenomesPNOC 
Exome Variant ServerPNOC
GNOMAD BrowserENSG00000168081
Varsome BrowserPNOC
ACMGPNOC variants
VarityQ13519
Genomic Variants (DGV)PNOC [DGVbeta]
DECIPHERPNOC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPNOC 
Mutations
ICGC Data PortalPNOC 
TCGA Data PortalPNOC 
Broad Tumor PortalPNOC
OASIS PortalPNOC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNOC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPNOC
Mutations and Diseases : HGMDPNOC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPNOC
DgiDB (Drug Gene Interaction Database)PNOC
DoCM (Curated mutations)PNOC
CIViC (Clinical Interpretations of Variants in Cancer)PNOC
Cancer3DPNOC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601459   
Orphanet
DisGeNETPNOC
MedgenPNOC
Genetic Testing Registry PNOC
NextProtQ13519 [Medical]
GENETestsPNOC
Target ValidationPNOC
Huge Navigator PNOC [HugePedia]
ClinGenPNOC
Clinical trials, drugs, therapy
MyCancerGenomePNOC
Protein Interactions : CTDPNOC
Pharm GKB GenePA33485
PharosQ13519
Clinical trialPNOC
Miscellaneous
canSAR (ICR)PNOC
HarmonizomePNOC
ARCHS4PNOC
DataMed IndexPNOC
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPNOC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:28:07 CET 2022

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