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PNP (purine nucleoside phosphorylase)

Identity

Other namesNP
PRO1837
PUNP
HGNC (Hugo) PNP
LocusID (NCBI) 4860
Location 14q11.2
Location_base_pair Starts at 20937538 and ends at 20946165 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)PNP   7892
Cards
Entrez_Gene (NCBI)PNP  4860  purine nucleoside phosphorylase
GeneCards (Weizmann)PNP
Ensembl (Hinxton) [Gene_View]  chr14:20937538-20946165 [Contig_View]  PNP [Vega]
cBioPortalPNP
AceView (NCBI)PNP
Genatlas (Paris)PNP
WikiGenes4860
SOURCE (Princeton)NM_000270
Genomic and cartography
GoldenPath (UCSC)PNP  -  14q11.2   chr14:20937538-20946165 +  14q11.2   [Description]    (hg19-Feb_2009)
EnsemblPNP - 14q11.2 [CytoView]
Mapping of homologs : NCBIPNP [Mapview]
OMIM164050   613179   
Gene and transcription
Genbank (Entrez)AK098544 AK126154 AK307340 AK307364 AK313490
RefSeq transcript (Entrez)NM_000270
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_009631 NT_026437 NW_001838110 NW_004929393
Consensus coding sequences : CCDS (NCBI)PNP
Cluster EST : UnigeneHs.75514 [ NCBI ]
CGAP (NCI)Hs.75514
Alternative Splicing : Fast-db (Paris)GSHG0008689
Gene ExpressionPNP [ NCBI-GEO ]     PNP [ SEEK ]   PNP [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00491 (Uniprot)
NextProtP00491  [Medical]
With graphics : InterProP00491
Splice isoforms : SwissVarP00491 (Swissvar)
Catalytic activity : Enzyme2.4.2.1 [ Enzyme-Expasy ]   2.4.2.12.4.2.1 [ IntEnz-EBI ]   2.4.2.1 [ BRENDA ]   2.4.2.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PNP_MTAP_2 (PS01240)   
Domains : Interpro (EBI)Nucleoside_phosphorylase_d [organisation]   PNP/MTAP [organisation]   Pur_Nuc_Pase_Ino/Guo-sp [organisation]   Purine_phosphorylase [organisation]   Purine_phosphorylase-2_CS [organisation]  
Related proteins : CluSTrP00491
Domain families : Pfam (Sanger)PNP_UDP_1 (PF01048)   
Domain families : Pfam (NCBI)pfam01048   
DMDM Disease mutations4860
Blocks (Seattle)P00491
PDB (SRS)1M73    1PF7    1PWY    1RCT    1RFG    1RR6    1RSZ    1RT9    1ULA    1ULB    1V2H    1V3Q    1V41    1V45    1YRY    2A0W    2A0X    2A0Y    2OC4    2OC9    2ON6    2Q7O    3BGS    3D1V    3GB9    3GGS    3INY    3K8O    3K8Q    3PHB    4EAR    4EB8    4ECE    4GKA   
PDB (PDBSum)1M73    1PF7    1PWY    1RCT    1RFG    1RR6    1RSZ    1RT9    1ULA    1ULB    1V2H    1V3Q    1V41    1V45    1YRY    2A0W    2A0X    2A0Y    2OC4    2OC9    2ON6    2Q7O    3BGS    3D1V    3GB9    3GGS    3INY    3K8O    3K8Q    3PHB    4EAR    4EB8    4ECE    4GKA   
PDB (IMB)1M73    1PF7    1PWY    1RCT    1RFG    1RR6    1RSZ    1RT9    1ULA    1ULB    1V2H    1V3Q    1V41    1V45    1YRY    2A0W    2A0X    2A0Y    2OC4    2OC9    2ON6    2Q7O    3BGS    3D1V    3GB9    3GGS    3INY    3K8O    3K8Q    3PHB    4EAR    4EB8    4ECE    4GKA   
PDB (RSDB)1M73    1PF7    1PWY    1RCT    1RFG    1RR6    1RSZ    1RT9    1ULA    1ULB    1V2H    1V3Q    1V41    1V45    1YRY    2A0W    2A0X    2A0Y    2OC4    2OC9    2ON6    2Q7O    3BGS    3D1V    3GB9    3GGS    3INY    3K8O    3K8Q    3PHB    4EAR    4EB8    4ECE    4GKA   
Peptide AtlasP00491
HPRD01247
IPIIPI00017672   IPI01024886   IPI01024768   IPI01025075   IPI01025985   
Protein Interaction databases
DIP (DOE-UCLA)P00491
IntAct (EBI)P00491
BioGRIDPNP
InParanoidP00491
Interologous Interaction database P00491
IntegromeDBPNP
STRING (EMBL)PNP
Ontologies - Pathways
Ontology : AmiGOnucleoside binding  purine nucleobase binding  purine-nucleoside phosphorylase activity  purine-nucleoside phosphorylase activity  intracellular  cytoplasm  cytosol  cytoskeleton  nucleobase-containing compound metabolic process  purine nucleobase metabolic process  inosine catabolic process  purine nucleotide catabolic process  nicotinamide riboside catabolic process  immune response  drug binding  NAD biosynthesis via nicotinamide riboside salvage pathway  urate biosynthetic process  positive regulation of T cell proliferation  phosphate ion binding  response to drug  response to drug  purine-containing compound salvage  small molecule metabolic process  positive regulation of alpha-beta T cell differentiation  nucleobase-containing small molecule metabolic process  extracellular vesicular exosome  interleukin-2 secretion  
Ontology : EGO-EBInucleoside binding  purine nucleobase binding  purine-nucleoside phosphorylase activity  purine-nucleoside phosphorylase activity  intracellular  cytoplasm  cytosol  cytoskeleton  nucleobase-containing compound metabolic process  purine nucleobase metabolic process  inosine catabolic process  purine nucleotide catabolic process  nicotinamide riboside catabolic process  immune response  drug binding  NAD biosynthesis via nicotinamide riboside salvage pathway  urate biosynthetic process  positive regulation of T cell proliferation  phosphate ion binding  response to drug  response to drug  purine-containing compound salvage  small molecule metabolic process  positive regulation of alpha-beta T cell differentiation  nucleobase-containing small molecule metabolic process  extracellular vesicular exosome  interleukin-2 secretion  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    Nicotinate and nicotinamide metabolism   
Protein Interaction DatabasePNP
Wikipedia pathwaysPNP
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PNP
snp3D : Map Gene to Disease4860
SNP (GeneSNP Utah)PNP
SNP : HGBasePNP
Genetic variants : HAPMAPPNP
Exome VariantPNP
1000_GenomesPNP 
Somatic Mutations in Cancer : COSMICPNP 
CONAN: Copy Number AnalysisPNP 
Mutations and Diseases : HGMDPNP
Mutations and Diseases : intOGenPNP
Genomic VariantsPNP  PNP [DGVbeta]
dbVarPNP
ClinVarPNP
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM164050    613179   
MedgenPNP
GENETestsPNP
Disease Genetic AssociationPNP
Huge Navigator PNP [HugePedia]  PNP [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePNP
Homology/Alignments : Family Browser (UCSC)PNP
Phylogenetic Trees/Animal Genes : TreeFamPNP
Chemical/Protein Interactions : CTD4860
Chemical/Pharm GKB GenePA31694
Clinical trialPNP
Other databases
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
CoreMinePNP
iHOPPNP
OncoSearchPNP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:00:26 CEST 2014

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