Identity
HGNC
LOCATION
7q31.1
LOCUSID
ALIAS
IPLA2-2,IPLA2G,MMLA,PNPLA-gamma,iPLA2gamma
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 50640
MIM: 612123
HGNC: 28900
Ensembl: ENSG00000135241
Variants:
dbSNP: 50640
ClinVar: 50640
TCGA: ENSG00000135241
COSMIC: PNPLA8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38017485 | 2023 | Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer. | 1 |
| 38017485 | 2023 | Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer. | 1 |
| 32161117 | 2020 | 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA(2)γ knockout. | 10 |
| 32161117 | 2020 | 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA(2)γ knockout. | 10 |
| 29158256 | 2018 | Heart failure-induced activation of phospholipase iPLA(2)γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. | 25 |
| 29681094 | 2018 | A neurodegenerative mitochondrial disease phenotype due to biallelic loss-of-function variants in PNPLA8 encoding calcium-independent phospholipase A2γ. | 10 |
| 29158256 | 2018 | Heart failure-induced activation of phospholipase iPLA(2)γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. | 25 |
| 29681094 | 2018 | A neurodegenerative mitochondrial disease phenotype due to biallelic loss-of-function variants in PNPLA8 encoding calcium-independent phospholipase A2γ. | 10 |
| 25313821 | 2014 | Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice. | 13 |
| 25313821 | 2014 | Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice. | 13 |
| 23258543 | 2013 | Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation. | 15 |
| 23429536 | 2013 | The absence of myocardial calcium-independent phospholipase A2γ results in impaired prostaglandin E2 production and decreased survival in mice with acute Trypanosoma cruzi infection. | 8 |
| 23258543 | 2013 | Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation. | 15 |
| 23429536 | 2013 | The absence of myocardial calcium-independent phospholipase A2γ results in impaired prostaglandin E2 production and decreased survival in mice with acute Trypanosoma cruzi infection. | 8 |
| 19892409 | 2010 | Schizophrenia: an association study targets phospholipase A2 genes as potential sites of susceptible genes. | 3 |
Citation
Dessen P
PNPLA8 (patatin like phospholipase domain containing 8)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46036/pnpla8
