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PNPO (pyridoxamine 5'-phosphate oxidase)

Identity

Other namesHEL-S-302
PDXPO
HGNC (Hugo) PNPO
LocusID (NCBI) 55163
Atlas_Id 42948
Location 17q21.32
Location_base_pair Starts at 46018889 and ends at 46026674 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLPTM1 (19q13.32) / PNPO (17q21.32)LENG8 (19q13.42) / PNPO (17q21.32)PNPO (17q21.32) / ALDH1A2 (15q21.3)
PNPO (17q21.32) / KCNT2 (1q31.3)PNPO (17q21.32) / NPEPPS (17q21.32)PNPO (17q21.32) / RNF141 (11p15.4)
PSMC5 (17q23.3) / PNPO (17q21.32)PNPO 17q21.32 / NPEPPS 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PNPO   30260
Cards
Entrez_Gene (NCBI)PNPO  55163  pyridoxamine 5'-phosphate oxidase
GeneCards (Weizmann)PNPO
Ensembl hg19 (Hinxton)ENSG00000108439 [Gene_View]  chr17:46018889-46026674 [Contig_View]  PNPO [Vega]
Ensembl hg38 (Hinxton)ENSG00000108439 [Gene_View]  chr17:46018889-46026674 [Contig_View]  PNPO [Vega]
ICGC DataPortalENSG00000108439
TCGA cBioPortalPNPO
AceView (NCBI)PNPO
Genatlas (Paris)PNPO
WikiGenes55163
SOURCE (Princeton)PNPO
Genomic and cartography
GoldenPath hg19 (UCSC)PNPO  -     chr17:46018889-46026674 +  17q21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PNPO  -     17q21.32   [Description]    (hg38-Dec_2013)
EnsemblPNPO - 17q21.32 [CytoView hg19]  PNPO - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIPNPO [Mapview hg19]  PNPO [Mapview hg38]
OMIM603287   610090   
Gene and transcription
Genbank (Entrez)AF468030 AK001397 AK223242 AK303536 AK303665
RefSeq transcript (Entrez)NM_018129
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008744 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)PNPO
Cluster EST : UnigeneHs.631742 [ NCBI ]
CGAP (NCI)Hs.631742
Alternative Splicing GalleryENSG00000108439
Gene ExpressionPNPO [ NCBI-GEO ]   PNPO [ EBI - ARRAY_EXPRESS ]   PNPO [ SEEK ]   PNPO [ MEM ]
Gene Expression Viewer (FireBrowse)PNPO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55163
GTEX Portal (Tissue expression)PNPO
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVS9 (Uniprot)
NextProtQ9NVS9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVS9
Splice isoforms : SwissVarQ9NVS9 (Swissvar)
Catalytic activity : Enzyme1.4.3.5 [ Enzyme-Expasy ]   1.4.3.51.4.3.5 [ IntEnz-EBI ]   1.4.3.5 [ BRENDA ]   1.4.3.5 [ KEGG ]   
PhosPhoSitePlusQ9NVS9
Domaine pattern : Prosite (Expaxy)PYRIDOX_OXIDASE (PS01064)   
Domains : Interpro (EBI)Pyridox_Oxase    Pyridox_Oxase_CS    Pyridox_Oxase_FMN-bd    Pyridoxamine_oxidase_dimer_C    Split_barrel_FMN-bd   
Domain families : Pfam (Sanger)PNPOx_C (PF10590)    Pyridox_oxidase (PF01243)   
Domain families : Pfam (NCBI)pfam10590    pfam01243   
DMDM Disease mutations55163
Blocks (Seattle)PNPO
PDB (SRS)1NRG    3HY8   
PDB (PDBSum)1NRG    3HY8   
PDB (IMB)1NRG    3HY8   
PDB (RSDB)1NRG    3HY8   
Structural Biology KnowledgeBase1NRG    3HY8   
SCOP (Structural Classification of Proteins)1NRG    3HY8   
CATH (Classification of proteins structures)1NRG    3HY8   
SuperfamilyQ9NVS9
Human Protein AtlasENSG00000108439
Peptide AtlasQ9NVS9
HPRD04476
IPIIPI00018272   IPI00793232   IPI00792667   IPI01013271   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVS9
IntAct (EBI)Q9NVS9
FunCoupENSG00000108439
BioGRIDPNPO
STRING (EMBL)PNPO
ZODIACPNPO
Ontologies - Pathways
QuickGOQ9NVS9
Ontology : AmiGOpositive regulation of defense response to virus by host  pyridoxamine-phosphate oxidase activity  pyridoxamine-phosphate oxidase activity  nucleoplasm  cytoplasm  cytosol  pyridoxine biosynthetic process  FMN binding  vitamin B6 metabolic process  pyridoxal phosphate biosynthetic process  oxidation-reduction process  extracellular exosome  mitophagy in response to mitochondrial depolarization  xenophagy  
Ontology : EGO-EBIpositive regulation of defense response to virus by host  pyridoxamine-phosphate oxidase activity  pyridoxamine-phosphate oxidase activity  nucleoplasm  cytoplasm  cytosol  pyridoxine biosynthetic process  FMN binding  vitamin B6 metabolic process  pyridoxal phosphate biosynthetic process  oxidation-reduction process  extracellular exosome  mitophagy in response to mitochondrial depolarization  xenophagy  
Pathways : KEGGVitamin B6 metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkPNPO
Wikipedia pathwaysPNPO
Orthology - Evolution
OrthoDB55163
GeneTree (enSembl)ENSG00000108439
Phylogenetic Trees/Animal Genes : TreeFamPNPO
Homologs : HomoloGenePNPO
Homology/Alignments : Family Browser (UCSC)PNPO
Gene fusions - Rearrangements
Fusion: TCGAPNPO 17q21.32 NPEPPS 17q21.32 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPNPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PNPO
dbVarPNPO
ClinVarPNPO
1000_GenomesPNPO 
Exome Variant ServerPNPO
ExAC (Exome Aggregation Consortium)PNPO (select the gene name)
Genetic variants : HAPMAP55163
Genomic Variants (DGV)PNPO [DGVbeta]
Mutations
ICGC Data PortalPNPO 
TCGA Data PortalPNPO 
Broad Tumor PortalPNPO
OASIS PortalPNPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPNPO 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PNPO
DgiDB (Drug Gene Interaction Database)PNPO
DoCM (Curated mutations)PNPO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PNPO (select a term)
intoGenPNPO
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:46018889-46026674  ENSG00000108439
CONAN: Copy Number AnalysisPNPO 
Mutations and Diseases : HGMDPNPO
OMIM603287    610090   
MedgenPNPO
Genetic Testing Registry PNPO
NextProtQ9NVS9 [Medical]
TSGene55163
GENETestsPNPO
Huge Navigator PNPO [HugePedia]
snp3D : Map Gene to Disease55163
BioCentury BCIQPNPO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55163
Chemical/Pharm GKB GenePA134915565
Clinical trialPNPO
Miscellaneous
canSAR (ICR)PNPO (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePNPO
EVEXPNPO
GoPubMedPNPO
iHOPPNPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:01:03 CEST 2016

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