| Nomenclature | | HGNC (Hugo) | POLA1 9173 |
| Entrez_Gene (NCBI) | POLA1 5422 polymerase (DNA directed), alpha 1, catalytic subunit |
| Cards | | GeneCards (Weizmann) | POLA1 |
| Ensembl (Hinxton) | ENSG00000101868 [Gene_View] chrX:24712064-25015102 [Contig_View] POLA1 [Vega] |
| AceView (NCBI) | POLA1 |
| Genatlas (Paris) | POLA1 |
| SOURCE (Stanford) | NM_016937 |
| Genomic and cartography | | GoldenPath (UCSC) | POLA1 - Xp22.11 chrX:24712064-25015102 + Xp22.11 [Description] (hg19-Feb_2009) |
| Ensembl | POLA1 - Xp22.11 [CytoView] |
| Mapping of homologs : NCBI | POLA1 [Mapview] |
| OMIM | 312040 |
| Gene and transcription |
| Genbank (Entrez) | BM664024 BU508486 BX648513 CN364591 DW462890 |
| RefSeq transcript (SRS) | NM_016937 |
| RefSeq transcript (Entrez) | NM_016937 |
| RefSeq genomic (SRS) | AC_000155 NC_000023 NC_018934 NG_016798 NT_167197 NW_001842360 NW_004078118 |
| RefSeq genomic (Entrez) | AC_000155 NC_000023 NC_018934 NG_016798 NT_167197 NW_001842360 NW_004078118 |
| Consensus coding sequences : CCDS (NCBI) | POLA1 |
| Cluster EST : Unigene | Hs.567319 [ SRS ] Hs.567319 [ NCBI ] |
| CGAP (NCI) | Hs.567319 |
| Alternative Splicing : Fast-db (Paris) | GSHG0031434 |
| Alternative Splicing Gallery | ENSG00000101868 |
| Gene Expression | POLA1 [ NCBI-GEO ] POLA1 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P09884 (SRS) P09884 (Uniprot) |
| NextProt | P09884 |
| With graphics : InterPro | P09884 |
| Splice isoforms : SwissVar | P09884(Swissvar) |
| Domaine pattern : Prosite (SRS) | DNA_POLYMERASE_B (PS00116) |
| Domaine pattern : Prosite (Expaxy) | DNA_POLYMERASE_B (PS00116) |
| Domains : Interpro (SRS) | DNA-dir_DNA_pol_B DNA-dir_DNA_pol_B_CS DNA-dir_DNA_pol_B_exonuc DNA-dir_DNA_pol_B_multi_dom DNA-dir_DNA_pol_B_pol2 DNA_pol_a_cat_su_N DNA_pol_palm_dom RNaseH-like_dom Znf_DNA-dir_DNA_pol_B_alpha |
| Domains : Interpro (EBI) | DNA-dir_DNA_pol_B DNA-dir_DNA_pol_B_CS DNA-dir_DNA_pol_B_exonuc DNA-dir_DNA_pol_B_multi_dom DNA-dir_DNA_pol_B_pol2 DNA_pol_a_cat_su_N DNA_pol_palm_dom RNaseH-like_dom Znf_DNA-dir_DNA_pol_B_alpha |
| Related proteins : CluSTr | P09884 |
| Domain families : Pfam (SRS) | DNA_pol_alpha_N (PF12254) DNA_pol_B (PF00136) DNA_pol_B_exo1 (PF03104) zf-DNA_Pol (PF08996) |
| Domain families : Pfam (Sanger) | DNA_pol_alpha_N (PF12254) DNA_pol_B (PF00136) DNA_pol_B_exo1 (PF03104) zf-DNA_Pol (PF08996) |
| Domain families : Pfam (NCBI) | pfam12254 pfam00136 pfam03104 pfam08996 |
| Domain families : Smart (EMBL) | POLBc (SM00486) |
| DMDM | 5422 |
| Blocks (Seattle) | P09884 |
| PDB (SRS) | 1K0P 1K18 1N5G |
| PDB (PDBSum) | 1K0P 1K18 1N5G |
| PDB (IMB) | 1K0P 1K18 1N5G |
| PDB (RSDB) | 1K0P 1K18 1N5G |
| Human Protein Atlas | ENSG00000101868 |
| HPRD | 02416 |
| IPI | IPI00220317 IPI00647655 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P09884 |
| IntAct (EBI) | P09884 |
| FunCoup | ENSG00000101868 |
| REACTOME | POLA1 |
| Protein Interaction Database | 5422 |
| BioGRID | POLA1 |
| InParanoid | P09884 |
| Interologous Interaction database | P09884 |
| IntegromeDB | POLA1 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | POLA1 |
| SNP (GeneSNP Utah) | POLA1 |
| SNP : HGBase | POLA1 |
| Genetic variants : HAPMAP | POLA1 |
| Somatic Mutations in Cancer : COSMIC | POLA1 |
| CONAN: Copy Number Analysis | POLA1 |
| Mutations and Diseases : HGMD | POLA1 |
| OMIM | 312040 |
| GENETests | 312040 |
| Disease Genetic Association | POLA1 |
| Huge Navigator |
POLA1 [HugePedia] POLA1 [HugeCancerGEM] |
| Genomic Variants | POLA1 POLA1 [DGVbeta] |
| snp3D : Map Gene to Disease | 5422 |
| General knowledge |
|---|
| Homologs : HomoloGene | POLA1 |
| Homology/Alignments : Family Browser (UCSC) | POLA1 |
| Phylogenetic Trees/Animal Genes : TreeFam | POLA1 |
| Catalytic activity : Enzyme | 2.7.7.7 [ Enzyme-Expasy ] 2.7.7.7 [ Enzyme-SRS ] 2.7.7.7 [ IntEnz-EBI ] 2.7.7.7 [ BRENDA ] 2.7.7.7 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 5422 |
| Chemical/Pharm GKB Gene | PA162399856 |
| Clinical trial | POLA1 |
| Cancer Resource (Charite) | ENSG00000101868 |
| Ontology : AmiGO | G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle S phase of mitotic cell cycle S phase of mitotic cell cycle nucleotide binding M/G1 transition of mitotic cell cycle mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair chromatin nucleoside binding DNA binding DNA binding chromatin binding double-stranded DNA binding DNA-directed DNA polymerase activity DNA-directed DNA polymerase activity DNA primase activity protein binding nucleus nuclear envelope nucleoplasm nucleoplasm alpha DNA polymerase:primase complex alpha DNA polymerase:primase complex nucleolus nucleolus cytoplasm DNA replication DNA replication, synthesis of RNA primer DNA replication initiation DNA replication initiation DNA strand elongation involved in DNA replication DNA strand elongation involved in DNA replication leading strand elongation lagging strand elongation DNA repair nucleotide-excision repair, DNA gap filling double-strand break repair via nonhomologous end joining cell proliferation 3'-5' exonuclease activity nuclear matrix purine nucleotide binding virus-host interaction pyrimidine nucleotide binding translesion synthesis telomere maintenance via semi-conservative replication intracellular membrane-bounded organelle metal ion binding protein heterodimerization activity 4 iron, 4 sulfur cluster binding |
| Ontology : EGO-EBI | G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle S phase of mitotic cell cycle S phase of mitotic cell cycle nucleotide binding M/G1 transition of mitotic cell cycle mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair chromatin nucleoside binding DNA binding DNA binding chromatin binding double-stranded DNA binding DNA-directed DNA polymerase activity DNA-directed DNA polymerase activity DNA primase activity protein binding nucleus nuclear envelope nucleoplasm nucleoplasm alpha DNA polymerase:primase complex alpha DNA polymerase:primase complex nucleolus nucleolus cytoplasm DNA replication DNA replication, synthesis of RNA primer DNA replication initiation DNA replication initiation DNA strand elongation involved in DNA replication DNA strand elongation involved in DNA replication leading strand elongation lagging strand elongation DNA repair nucleotide-excision repair, DNA gap filling double-strand break repair via nonhomologous end joining cell proliferation 3'-5' exonuclease activity nuclear matrix purine nucleotide binding virus-host interaction pyrimidine nucleotide binding translesion synthesis telomere maintenance via semi-conservative replication intracellular membrane-bounded organelle metal ion binding protein heterodimerization activity 4 iron, 4 sulfur cluster binding |
| Pathways : KEGG | Purine metabolismPyrimidine metabolismDNA polymerase |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 72 Pubmed reference(s) in Entrez |
| PubGene | POLA1 |
| iHOP | POLA1 |
