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POLA2 (DNA polymerase alpha 2, accessory subunit)

Identity

Alias_namespolymerase (DNA directed), alpha 2 (70kD subunit)
polymerase (DNA) alpha 2, accessory subunit
Alias_symbol (synonym)FLJ21662
Other alias-
HGNC (Hugo) POLA2
LocusID (NCBI) 23649
Atlas_Id 43415
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65261852 and ends at 65298685 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DPF2 (11q13.1) / POLA2 (11q13.1)EIF3B (7p22.3) / POLA2 (11q13.1)POLA2 (11q13.1) / AP000790.1 ()
POLA2 (11q13.1) / CAPN1 (11q13.1)POLA2 (11q13.1) / CDC42EP2 (11q13.1)POLA2 (11q13.1) / PPFIA1 (11q13.3)
RPL10 (Xq28) / POLA2 (11q13.1)DPF2 11q13.1 / POLA2 11q13.1POLA2 11q13.1 AP000790.1
POLA2 11q13.1 / PPFIA1 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLA2   30073
Cards
Entrez_Gene (NCBI)POLA2  23649  DNA polymerase alpha 2, accessory subunit
Aliases
GeneCards (Weizmann)POLA2
Ensembl hg19 (Hinxton)ENSG00000014138 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000014138 [Gene_View]  chr11:65261852-65298685 [Contig_View]  POLA2 [Vega]
ICGC DataPortalENSG00000014138
TCGA cBioPortalPOLA2
AceView (NCBI)POLA2
Genatlas (Paris)POLA2
WikiGenes23649
SOURCE (Princeton)POLA2
Genetics Home Reference (NIH)POLA2
Genomic and cartography
GoldenPath hg38 (UCSC)POLA2  -     chr11:65261852-65298685 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLA2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblPOLA2 - 11q13.1 [CytoView hg19]  POLA2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIPOLA2 [Mapview hg19]  POLA2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK025315 AK094569 AK297842 AK307831 AK309284
RefSeq transcript (Entrez)NM_002689
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLA2
Cluster EST : UnigeneHs.201897 [ NCBI ]
CGAP (NCI)Hs.201897
Alternative Splicing GalleryENSG00000014138
Gene ExpressionPOLA2 [ NCBI-GEO ]   POLA2 [ EBI - ARRAY_EXPRESS ]   POLA2 [ SEEK ]   POLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)POLA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23649
GTEX Portal (Tissue expression)POLA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14181
Splice isoforms : SwissVarQ14181
PhosPhoSitePlusQ14181
Domains : Interpro (EBI)DNA_pol_alpha/epsilon_bsu    DNA_pol_alpha_bsu    Pol_alpha_B_N   
Domain families : Pfam (Sanger)DNA_pol_E_B (PF04042)    Pol_alpha_B_N (PF08418)   
Domain families : Pfam (NCBI)xf!m04042    pfam08418   
Conserved Domain (NCBI)POLA2
DMDM Disease mutations23649
Blocks (Seattle)POLA2
PDB (SRS)2KEB    4E2I    4Y97    5EXR   
PDB (PDBSum)2KEB    4E2I    4Y97    5EXR   
PDB (IMB)2KEB    4E2I    4Y97    5EXR   
PDB (RSDB)2KEB    4E2I    4Y97    5EXR   
Structural Biology KnowledgeBase2KEB    4E2I    4Y97    5EXR   
SCOP (Structural Classification of Proteins)2KEB    4E2I    4Y97    5EXR   
CATH (Classification of proteins structures)2KEB    4E2I    4Y97    5EXR   
SuperfamilyQ14181
Human Protein AtlasENSG00000014138
Peptide AtlasQ14181
HPRD10160
IPIIPI00290272   IPI00908664   IPI00976173   IPI00975505   IPI00977310   
Protein Interaction databases
DIP (DOE-UCLA)Q14181
IntAct (EBI)Q14181
FunCoupENSG00000014138
BioGRIDPOLA2
STRING (EMBL)POLA2
ZODIACPOLA2
Ontologies - Pathways
QuickGOQ14181
Ontology : AmiGOprotein import into nucleus, translocation  G1/S transition of mitotic cell cycle  telomere maintenance via recombination  molecular_function  DNA binding  DNA-directed DNA polymerase activity  nucleoplasm  nucleoplasm  alpha DNA polymerase:primase complex  cytosol  DNA replication  DNA replication initiation  DNA replication initiation  protein heterodimerization activity  DNA biosynthetic process  
Ontology : EGO-EBIprotein import into nucleus, translocation  G1/S transition of mitotic cell cycle  telomere maintenance via recombination  molecular_function  DNA binding  DNA-directed DNA polymerase activity  nucleoplasm  nucleoplasm  alpha DNA polymerase:primase complex  cytosol  DNA replication  DNA replication initiation  DNA replication initiation  protein heterodimerization activity  DNA biosynthetic process  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication   
NDEx NetworkPOLA2
Atlas of Cancer Signalling NetworkPOLA2
Wikipedia pathwaysPOLA2
Orthology - Evolution
OrthoDB23649
GeneTree (enSembl)ENSG00000014138
Phylogenetic Trees/Animal Genes : TreeFamPOLA2
HOVERGENQ14181
HOGENOMQ14181
Homologs : HomoloGenePOLA2
Homology/Alignments : Family Browser (UCSC)POLA2
Gene fusions - Rearrangements
Fusion : MitelmanDPF2/POLA2 [11q13.1/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPOLA2/CAPN1 [11q13.1/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPOLA2/PPFIA1 [11q13.1/11q13.3]  [t(11;11)(q13;q13)]  
Fusion: TCGADPF2 11q13.1 POLA2 11q13.1 GBM
Fusion: TCGAPOLA2 11q13.1 AP000790.1 LUAD
Fusion: TCGAPOLA2 11q13.1 PPFIA1 11q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLA2
dbVarPOLA2
ClinVarPOLA2
1000_GenomesPOLA2 
Exome Variant ServerPOLA2
ExAC (Exome Aggregation Consortium)POLA2 (select the gene name)
Genetic variants : HAPMAP23649
Genomic Variants (DGV)POLA2 [DGVbeta]
DECIPHERPOLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLA2 
Mutations
ICGC Data PortalPOLA2 
TCGA Data PortalPOLA2 
Broad Tumor PortalPOLA2
OASIS PortalPOLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLA2
DgiDB (Drug Gene Interaction Database)POLA2
DoCM (Curated mutations)POLA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLA2 (select a term)
intoGenPOLA2
Cancer3DPOLA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPOLA2
Genetic Testing Registry POLA2
NextProtQ14181 [Medical]
TSGene23649
GENETestsPOLA2
Target ValidationPOLA2
Huge Navigator POLA2 [HugePedia]
snp3D : Map Gene to Disease23649
BioCentury BCIQPOLA2
ClinGenPOLA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23649
Chemical/Pharm GKB GenePA411
Clinical trialPOLA2
Miscellaneous
canSAR (ICR)POLA2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLA2
EVEXPOLA2
GoPubMedPOLA2
iHOPPOLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

indexed on : Mon Sep 25 19:25:34 CEST 2017
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