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POLA2 (DNA polymerase alpha 2, accessory subunit)

Identity

Alias (NCBI)-
HGNC (Hugo) POLA2
HGNC Alias symbFLJ21662
HGNC Alias nameDNA polymerase alpha subunit B
 DNA polymerase alpha 70 kDa subunit
HGNC Previous namepolymerase (DNA directed), alpha 2 (70kD subunit)
 polymerase (DNA) alpha 2, accessory subunit
LocusID (NCBI) 23649
Atlas_Id 43415
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65261962 and ends at 65298685 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPF2 (11q13.1) / POLA2 (11q13.1)EIF3B (7p22.3) / POLA2 (11q13.1)POLA2 (11q13.1) / AP000790.1 ()
POLA2 (11q13.1) / CAPN1 (11q13.1)POLA2 (11q13.1) / CDC42EP2 (11q13.1)POLA2 (11q13.1) / PPFIA1 (11q13.3)
RPL10 (Xq28) / POLA2 (11q13.1)DPF2 11q13.1 / POLA2 11q13.1POLA2 11q13.1 AP000790.1
POLA2 11q13.1 / PPFIA1 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)POLA2   30073
Cards
Entrez_Gene (NCBI)POLA2    DNA polymerase alpha 2, accessory subunit
Aliases
GeneCards (Weizmann)POLA2
Ensembl hg19 (Hinxton)ENSG00000014138 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000014138 [Gene_View]  ENSG00000014138 [Sequence]  chr11:65261962-65298685 [Contig_View]  POLA2 [Vega]
ICGC DataPortalENSG00000014138
TCGA cBioPortalPOLA2
AceView (NCBI)POLA2
Genatlas (Paris)POLA2
SOURCE (Princeton)POLA2
Genetics Home Reference (NIH)POLA2
Genomic and cartography
GoldenPath hg38 (UCSC)POLA2  -     chr11:65261962-65298685 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLA2  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPOLA2 - 11q13.1 [CytoView hg19]  POLA2 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000014138
Genome Data Viewer NCBIPOLA2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK025315 AK094569 AK297842 AK307831 AK309284
RefSeq transcript (Entrez)NM_002689
Consensus coding sequences : CCDS (NCBI)POLA2
Gene ExpressionPOLA2 [ NCBI-GEO ]   POLA2 [ EBI - ARRAY_EXPRESS ]   POLA2 [ SEEK ]   POLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)POLA2 [ Firebrowse - Broad ]
GenevisibleExpression of POLA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23649
GTEX Portal (Tissue expression)POLA2
Human Protein AtlasENSG00000014138-POLA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14181
PhosPhoSitePlusQ14181
Domains : Interpro (EBI)DNA_pol_a/d/e_bsu    DNA_pol_alpha_B_N_sf    DNA_pol_alpha_bsu    Pol_alpha_B_N   
Domain families : Pfam (Sanger)DNA_pol_E_B (PF04042)    Pol_alpha_B_N (PF08418)   
Domain families : Pfam (NCBI)pfam04042    pfam08418   
Conserved Domain (NCBI)POLA2
PDB (RSDB)2KEB    4E2I    4Y97    5EXR   
PDB Europe2KEB    4E2I    4Y97    5EXR   
PDB (PDBSum)2KEB    4E2I    4Y97    5EXR   
PDB (IMB)2KEB    4E2I    4Y97    5EXR   
Structural Biology KnowledgeBase2KEB    4E2I    4Y97    5EXR   
SCOP (Structural Classification of Proteins)2KEB    4E2I    4Y97    5EXR   
CATH (Classification of proteins structures)2KEB    4E2I    4Y97    5EXR   
SuperfamilyQ14181
AlphaFold pdb e-kbQ14181   
Human Protein Atlas [tissue]ENSG00000014138-POLA2 [tissue]
HPRD10160
Protein Interaction databases
DIP (DOE-UCLA)Q14181
IntAct (EBI)Q14181
BioGRIDPOLA2
STRING (EMBL)POLA2
ZODIACPOLA2
Ontologies - Pathways
QuickGOQ14181
Ontology : AmiGOmolecular_function  DNA binding  protein binding  nucleoplasm  nucleoplasm  alpha DNA polymerase:primase complex  alpha DNA polymerase:primase complex  cytosol  DNA replication  DNA replication, synthesis of RNA primer  DNA replication initiation  DNA replication initiation  telomere maintenance via semi-conservative replication  
Ontology : EGO-EBImolecular_function  DNA binding  protein binding  nucleoplasm  nucleoplasm  alpha DNA polymerase:primase complex  alpha DNA polymerase:primase complex  cytosol  DNA replication  DNA replication, synthesis of RNA primer  DNA replication initiation  DNA replication initiation  telomere maintenance via semi-conservative replication  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication   
NDEx NetworkPOLA2
Atlas of Cancer Signalling NetworkPOLA2
Wikipedia pathwaysPOLA2
Orthology - Evolution
OrthoDB23649
GeneTree (enSembl)ENSG00000014138
Phylogenetic Trees/Animal Genes : TreeFamPOLA2
Homologs : HomoloGenePOLA2
Homology/Alignments : Family Browser (UCSC)POLA2
Gene fusions - Rearrangements
Fusion : MitelmanDPF2/POLA2 [11q13.1/11q13.1]  
Fusion : MitelmanPOLA2/CAPN1 [11q13.1/11q13.1]  
Fusion : MitelmanPOLA2/PPFIA1 [11q13.1/11q13.3]  
Fusion : QuiverPOLA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLA2
dbVarPOLA2
ClinVarPOLA2
MonarchPOLA2
1000_GenomesPOLA2 
Exome Variant ServerPOLA2
GNOMAD BrowserENSG00000014138
Varsome BrowserPOLA2
ACMGPOLA2 variants
VarityQ14181
Genomic Variants (DGV)POLA2 [DGVbeta]
DECIPHERPOLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLA2 
Mutations
ICGC Data PortalPOLA2 
TCGA Data PortalPOLA2 
Broad Tumor PortalPOLA2
OASIS PortalPOLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLA2
Mutations and Diseases : HGMDPOLA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPOLA2
DgiDB (Drug Gene Interaction Database)POLA2
DoCM (Curated mutations)POLA2
CIViC (Clinical Interpretations of Variants in Cancer)POLA2
Cancer3DPOLA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPOLA2
MedgenPOLA2
Genetic Testing Registry POLA2
NextProtQ14181 [Medical]
GENETestsPOLA2
Target ValidationPOLA2
Huge Navigator POLA2 [HugePedia]
ClinGenPOLA2
Clinical trials, drugs, therapy
MyCancerGenomePOLA2
Protein Interactions : CTDPOLA2
Pharm GKB GenePA411
PharosQ14181
Clinical trialPOLA2
Miscellaneous
canSAR (ICR)POLA2
HarmonizomePOLA2
DataMed IndexPOLA2
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPOLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:01 CEST 2021

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