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POLB (DNA polymerase beta)

Identity

Alias_namespolymerase (DNA directed), beta
polymerase (DNA) beta
Other alias-
HGNC (Hugo) POLB
LocusID (NCBI) 5423
Atlas_Id 41769
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 42338455 and ends at 42371813 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNAB2 (1p36.31) / POLB (8p11.21)PDE10A (6q27) / POLB (8p11.21)POLB (8p11.21) / UNC5D (8p12)
POLB (8p11.21) / UVRAG (11q13.5)KCNAB2 1p36.31 / POLB 8p11.21PDE10A 6q27 / POLB 8p11.21
POLB 8p11.21 / UNC5D 8p12POLB 8p11.21 / UVRAG 11q13.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLB   9174
Cards
Entrez_Gene (NCBI)POLB  5423  DNA polymerase beta
Aliases
GeneCards (Weizmann)POLB
Ensembl hg19 (Hinxton)ENSG00000070501 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070501 [Gene_View]  chr8:42338455-42371813 [Contig_View]  POLB [Vega]
ICGC DataPortalENSG00000070501
TCGA cBioPortalPOLB
AceView (NCBI)POLB
Genatlas (Paris)POLB
WikiGenes5423
SOURCE (Princeton)POLB
Genetics Home Reference (NIH)POLB
Genomic and cartography
GoldenPath hg38 (UCSC)POLB  -     chr8:42338455-42371813 +  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLB  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblPOLB - 8p11.21 [CytoView hg19]  POLB - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIPOLB [Mapview hg19]  POLB [Mapview hg38]
OMIM174760   
Gene and transcription
Genbank (Entrez)AK223537 AK294025 AK314976 BC100288 BC106909
RefSeq transcript (Entrez)NM_002690
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLB
Cluster EST : UnigeneHs.661106 [ NCBI ]
CGAP (NCI)Hs.661106
Alternative Splicing GalleryENSG00000070501
Gene ExpressionPOLB [ NCBI-GEO ]   POLB [ EBI - ARRAY_EXPRESS ]   POLB [ SEEK ]   POLB [ MEM ]
Gene Expression Viewer (FireBrowse)POLB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5423
GTEX Portal (Tissue expression)POLB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06746   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06746  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06746
Splice isoforms : SwissVarP06746
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
PhosPhoSitePlusP06746
Domaine pattern : Prosite (Expaxy)DNA_POLYMERASE_X (PS00522)   
Domains : Interpro (EBI)DNA-dir_DNA_pol_X    DNA_pol-X_BS    DNA_pol_b-like_N    DNA_pol_B_palm_palm    DNA_pol_lambd_fingers_domain    DNA_pol_X    DNA_pol_X_beta-like    Hlx-hairpin-Hlx_DNA-bd_motif    PolB_N    PolB_thumb   
Domain families : Pfam (Sanger)DNA_pol_B_palm (PF14792)    DNA_pol_B_thumb (PF14791)    DNA_pol_lambd_f (PF10391)    HHH_8 (PF14716)   
Domain families : Pfam (NCBI)pfam14792    pfam14791    pfam10391    pfam14716   
Domain families : Smart (EMBL)HhH1 (SM00278)  POLXc (SM00483)  
Conserved Domain (NCBI)POLB
DMDM Disease mutations5423
Blocks (Seattle)POLB
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP06746
Human Protein AtlasENSG00000070501
Peptide AtlasP06746
HPRD07517
IPIIPI00219538   IPI00984855   IPI00980486   IPI00973464   IPI00981942   IPI00981347   IPI00983751   IPI00982515   IPI00980775   IPI00979489   IPI00983102   
Protein Interaction databases
DIP (DOE-UCLA)P06746
IntAct (EBI)P06746
FunCoupENSG00000070501
BioGRIDPOLB
STRING (EMBL)POLB
ZODIACPOLB
Ontologies - Pathways
QuickGOP06746
Ontology : AmiGOdamaged DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  DNA-(apurinic or apyrimidinic site) lyase activity  protein binding  nucleus  nucleoplasm  cytoplasm  microtubule  spindle microtubule  DNA-dependent DNA replication  DNA repair  base-excision repair  base-excision repair  base-excision repair, base-free sugar-phosphate removal  base-excision repair, gap-filling  base-excision repair, DNA ligation  pyrimidine dimer repair  nucleotide-excision repair, DNA gap filling  inflammatory response  cellular response to DNA damage stimulus  salivary gland morphogenesis  aging  microtubule binding  intrinsic apoptotic signaling pathway in response to DNA damage  response to gamma radiation  somatic hypermutation of immunoglobulin genes  protein deubiquitination  lyase activity  enzyme binding  protein complex  response to ethanol  metal ion binding  lymph node development  spleen development  homeostasis of number of cells  neuron apoptotic process  response to hyperoxia  immunoglobulin heavy chain V-D-J recombination  DNA biosynthetic process  
Ontology : EGO-EBIdamaged DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  DNA-(apurinic or apyrimidinic site) lyase activity  protein binding  nucleus  nucleoplasm  cytoplasm  microtubule  spindle microtubule  DNA-dependent DNA replication  DNA repair  base-excision repair  base-excision repair  base-excision repair, base-free sugar-phosphate removal  base-excision repair, gap-filling  base-excision repair, DNA ligation  pyrimidine dimer repair  nucleotide-excision repair, DNA gap filling  inflammatory response  cellular response to DNA damage stimulus  salivary gland morphogenesis  aging  microtubule binding  intrinsic apoptotic signaling pathway in response to DNA damage  response to gamma radiation  somatic hypermutation of immunoglobulin genes  protein deubiquitination  lyase activity  enzyme binding  protein complex  response to ethanol  metal ion binding  lymph node development  spleen development  homeostasis of number of cells  neuron apoptotic process  response to hyperoxia  immunoglobulin heavy chain V-D-J recombination  DNA biosynthetic process  
Pathways : KEGGBase excision repair    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkPOLB
Atlas of Cancer Signalling NetworkPOLB
Wikipedia pathwaysPOLB
Orthology - Evolution
OrthoDB5423
GeneTree (enSembl)ENSG00000070501
Phylogenetic Trees/Animal Genes : TreeFamPOLB
HOVERGENP06746
HOGENOMP06746
Homologs : HomoloGenePOLB
Homology/Alignments : Family Browser (UCSC)POLB
Gene fusions - Rearrangements
Fusion : MitelmanKCNAB2/POLB [1p36.31/8p11.21]  [t(1;8)(p36;p11)]  
Fusion : MitelmanPDE10A/POLB [6q27/8p11.21]  [t(6;8)(q27;p11)]  
Fusion : MitelmanPOLB/UNC5D [8p11.21/8p12]  [t(8;8)(p11;p12)]  
Fusion : MitelmanPOLB/UVRAG [8p11.21/11q13.5]  [t(8;11)(p11;q13)]  
Fusion: TCGAKCNAB2 1p36.31 POLB 8p11.21 LUSC
Fusion: TCGAPDE10A 6q27 POLB 8p11.21 BRCA
Fusion: TCGAPOLB 8p11.21 UNC5D 8p12 LUAD
Fusion: TCGAPOLB 8p11.21 UVRAG 11q13.5 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLB
dbVarPOLB
ClinVarPOLB
1000_GenomesPOLB 
Exome Variant ServerPOLB
ExAC (Exome Aggregation Consortium)POLB (select the gene name)
Genetic variants : HAPMAP5423
Genomic Variants (DGV)POLB [DGVbeta]
DECIPHERPOLB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLB 
Mutations
ICGC Data PortalPOLB 
TCGA Data PortalPOLB 
Broad Tumor PortalPOLB
OASIS PortalPOLB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLB
DgiDB (Drug Gene Interaction Database)POLB
DoCM (Curated mutations)POLB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLB (select a term)
intoGenPOLB
Cancer3DPOLB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM174760   
Orphanet
MedgenPOLB
Genetic Testing Registry POLB
NextProtP06746 [Medical]
TSGene5423
GENETestsPOLB
Target ValidationPOLB
Huge Navigator POLB [HugePedia]
snp3D : Map Gene to Disease5423
BioCentury BCIQPOLB
ClinGenPOLB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5423
Chemical/Pharm GKB GenePA276
Clinical trialPOLB
Miscellaneous
canSAR (ICR)POLB (select the gene name)
Probes
Litterature
PubMed193 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLB
EVEXPOLB
GoPubMedPOLB
iHOPPOLB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:50:11 CEST 2017

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