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POLD2 (DNA polymerase delta 2, accessory subunit)

Identity

Alias_namespolymerase (DNA directed), delta 2, regulatory subunit (50kD)
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA) delta 2, accessory subunit
Other alias-
HGNC (Hugo) POLD2
LocusID (NCBI) 5425
Atlas_Id 43416
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44114680 and ends at 44123570 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLD2 (7p13) / CHST14 (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLD2   9176
Cards
Entrez_Gene (NCBI)POLD2  5425  DNA polymerase delta 2, accessory subunit
Aliases
GeneCards (Weizmann)POLD2
Ensembl hg19 (Hinxton)ENSG00000106628 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106628 [Gene_View]  chr7:44114680-44123570 [Contig_View]  POLD2 [Vega]
ICGC DataPortalENSG00000106628
TCGA cBioPortalPOLD2
AceView (NCBI)POLD2
Genatlas (Paris)POLD2
WikiGenes5425
SOURCE (Princeton)POLD2
Genetics Home Reference (NIH)POLD2
Genomic and cartography
GoldenPath hg38 (UCSC)POLD2  -     chr7:44114680-44123570 -  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLD2  -     7p13   [Description]    (hg19-Feb_2009)
EnsemblPOLD2 - 7p13 [CytoView hg19]  POLD2 - 7p13 [CytoView hg38]
Mapping of homologs : NCBIPOLD2 [Mapview hg19]  POLD2 [Mapview hg38]
OMIM600815   
Gene and transcription
Genbank (Entrez)AK292347 AK298168 AK312294 AU117477 AW732014
RefSeq transcript (Entrez)NM_001127218 NM_001256879 NM_006230
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLD2
Cluster EST : UnigeneHs.740138 [ NCBI ]
CGAP (NCI)Hs.740138
Alternative Splicing GalleryENSG00000106628
Gene ExpressionPOLD2 [ NCBI-GEO ]   POLD2 [ EBI - ARRAY_EXPRESS ]   POLD2 [ SEEK ]   POLD2 [ MEM ]
Gene Expression Viewer (FireBrowse)POLD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5425
GTEX Portal (Tissue expression)POLD2
Human Protein AtlasENSG00000106628-POLD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49005   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49005  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49005
Splice isoforms : SwissVarP49005
PhosPhoSitePlusP49005
Domains : Interpro (EBI)DNA_pol_alpha/epsilon_bsu    DNA_pol_delta/II_ssu   
Domain families : Pfam (Sanger)DNA_pol_E_B (PF04042)   
Domain families : Pfam (NCBI)pfam04042   
Conserved Domain (NCBI)POLD2
DMDM Disease mutations5425
Blocks (Seattle)POLD2
PDB (SRS)3E0J   
PDB (PDBSum)3E0J   
PDB (IMB)3E0J   
PDB (RSDB)3E0J   
Structural Biology KnowledgeBase3E0J   
SCOP (Structural Classification of Proteins)3E0J   
CATH (Classification of proteins structures)3E0J   
SuperfamilyP49005
Human Protein Atlas [tissue]ENSG00000106628-POLD2 [tissue]
Peptide AtlasP49005
HPRD15982
IPIIPI00025616   IPI00909525   IPI00925787   IPI00927870   IPI00927214   IPI00927382   IPI00926735   IPI00925651   
Protein Interaction databases
DIP (DOE-UCLA)P49005
IntAct (EBI)P49005
FunCoupENSG00000106628
BioGRIDPOLD2
STRING (EMBL)POLD2
ZODIACPOLD2
Ontologies - Pathways
QuickGOP49005
Ontology : AmiGOtelomere maintenance via recombination  telomere maintenance  DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA ligation  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  cellular response to DNA damage stimulus  translesion synthesis  nucleotide-excision repair, DNA incision  DNA damage response, detection of DNA damage  delta DNA polymerase complex  
Ontology : EGO-EBItelomere maintenance via recombination  telomere maintenance  DNA binding  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA ligation  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  cellular response to DNA damage stimulus  translesion synthesis  nucleotide-excision repair, DNA incision  DNA damage response, detection of DNA damage  delta DNA polymerase complex  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication    Base excision repair    Nucleotide excision repair    Mismatch repair    Homologous recombination    HTLV-I infection   
NDEx NetworkPOLD2
Atlas of Cancer Signalling NetworkPOLD2
Wikipedia pathwaysPOLD2
Orthology - Evolution
OrthoDB5425
GeneTree (enSembl)ENSG00000106628
Phylogenetic Trees/Animal Genes : TreeFamPOLD2
HOVERGENP49005
HOGENOMP49005
Homologs : HomoloGenePOLD2
Homology/Alignments : Family Browser (UCSC)POLD2
Gene fusions - Rearrangements
Fusion: Tumor Portal POLD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLD2
dbVarPOLD2
ClinVarPOLD2
1000_GenomesPOLD2 
Exome Variant ServerPOLD2
ExAC (Exome Aggregation Consortium)ENSG00000106628
GNOMAD BrowserENSG00000106628
Genetic variants : HAPMAP5425
Genomic Variants (DGV)POLD2 [DGVbeta]
DECIPHERPOLD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLD2 
Mutations
ICGC Data PortalPOLD2 
TCGA Data PortalPOLD2 
Broad Tumor PortalPOLD2
OASIS PortalPOLD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLD2
DgiDB (Drug Gene Interaction Database)POLD2
DoCM (Curated mutations)POLD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLD2 (select a term)
intoGenPOLD2
Cancer3DPOLD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600815   
Orphanet
MedgenPOLD2
Genetic Testing Registry POLD2
NextProtP49005 [Medical]
TSGene5425
GENETestsPOLD2
Target ValidationPOLD2
Huge Navigator POLD2 [HugePedia]
snp3D : Map Gene to Disease5425
BioCentury BCIQPOLD2
ClinGenPOLD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5425
Chemical/Pharm GKB GenePA33497
Clinical trialPOLD2
Miscellaneous
canSAR (ICR)POLD2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLD2
EVEXPOLD2
GoPubMedPOLD2
iHOPPOLD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:05:49 CET 2017

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