| Nomenclature |
|---|
| HGNC (Hugo) | POLD3 20932 |
| Cards |
|---|
| Entrez_Gene (NCBI) | POLD3 10714 DNA polymerase delta 3, accessory subunit |
| Aliases | P66; P68; PPP1R128 |
| GeneCards (Weizmann) | POLD3 |
| Ensembl hg19 (Hinxton) | ENSG00000077514 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000077514 [Gene_View] chr11:74592530-74643060 [Contig_View] POLD3 [Vega] |
| ICGC DataPortal | ENSG00000077514 |
| TCGA cBioPortal | POLD3 |
| AceView (NCBI) | POLD3 |
| Genatlas (Paris) | POLD3 |
| WikiGenes | 10714 |
| SOURCE (Princeton) | POLD3 |
| Genetics Home Reference (NIH) | POLD3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | POLD3 - chr11:74592530-74643060 + 11q13.4 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | POLD3 - 11q13.4 [Description] (hg19-Feb_2009) |
| Ensembl | POLD3 - 11q13.4 [CytoView hg19] POLD3 - 11q13.4 [CytoView hg38] |
| Mapping of homologs : NCBI | POLD3 [Mapview hg19] POLD3 [Mapview hg38] |
| OMIM | 611415 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK297375 AK302677 AK316301 AK316370 BC020587 |
| RefSeq transcript (Entrez) | NM_006591 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | POLD3 |
| Cluster EST : Unigene | Hs.82502 [ NCBI ] |
| CGAP (NCI) | Hs.82502 |
| Alternative Splicing Gallery | ENSG00000077514 |
| Gene Expression | POLD3 [ NCBI-GEO ] POLD3 [ EBI - ARRAY_EXPRESS ]
POLD3 [ SEEK ] POLD3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | POLD3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 10714 |
| GTEX Portal (Tissue expression) | POLD3 |
| Human Protein Atlas | ENSG00000077514-POLD3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q15054 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q15054 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q15054 |
| Splice isoforms : SwissVar | Q15054 |
| PhosPhoSitePlus | Q15054 |
| Domains : Interpro (EBI) | DNA_polymerase_subunit_Cdc27 |
| Domain families : Pfam (Sanger) | CDC27 (PF09507) |
| Domain families : Pfam (NCBI) | pfam09507 |
| Conserved Domain (NCBI) | POLD3 |
| DMDM Disease mutations | 10714 |
| Blocks (Seattle) | POLD3 |
| PDB (SRS) | 1U76 2N1G 3E0J |
| PDB (PDBSum) | 1U76 2N1G 3E0J |
| PDB (IMB) | 1U76 2N1G 3E0J |
| PDB (RSDB) | 1U76 2N1G 3E0J |
| Structural Biology KnowledgeBase | 1U76 2N1G 3E0J |
| SCOP (Structural Classification of Proteins) | 1U76 2N1G 3E0J |
| CATH (Classification of proteins structures) | 1U76 2N1G 3E0J |
| Superfamily | Q15054 |
| Human Protein Atlas [tissue] | ENSG00000077514-POLD3 [tissue] |
| Peptide Atlas | Q15054 |
| HPRD | 11446 |
| IPI | IPI00394926 IPI00984074 IPI00983388 IPI00984472 IPI00976030 IPI00982783 IPI00976696 IPI00984780 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q15054 |
| IntAct (EBI) | Q15054 |
| FunCoup | ENSG00000077514 |
| BioGRID | POLD3 |
| STRING (EMBL) | POLD3 |
| ZODIAC | POLD3 |
| Ontologies - Pathways |
|---|
| QuickGO | Q15054 |
| Ontology : AmiGO | telomere maintenance DNA synthesis involved in DNA repair DNA-directed DNA polymerase activity DNA-directed DNA polymerase activity protein binding nucleus nucleoplasm cytoplasm DNA ligation transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling mismatch repair mismatch repair translesion synthesis telomere maintenance via semi-conservative replication nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage delta DNA polymerase complex |
| Ontology : EGO-EBI | telomere maintenance DNA synthesis involved in DNA repair DNA-directed DNA polymerase activity DNA-directed DNA polymerase activity protein binding nucleus nucleoplasm cytoplasm DNA ligation transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling mismatch repair mismatch repair translesion synthesis telomere maintenance via semi-conservative replication nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage delta DNA polymerase complex |
| Pathways : KEGG | DNA polymerase Pyrimidine metabolism Purine metabolism |
| NDEx Network | POLD3 |
| Atlas of Cancer Signalling Network | POLD3 |
| Wikipedia pathways | POLD3 |
| Orthology - Evolution |
|---|
| OrthoDB | 10714 |
| GeneTree (enSembl) | ENSG00000077514 |
| Phylogenetic Trees/Animal Genes : TreeFam | POLD3 |
| HOVERGEN | Q15054 |
| HOGENOM | Q15054 |
| Homologs : HomoloGene | POLD3 |
| Homology/Alignments : Family Browser (UCSC) | POLD3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | INTS4/POLD3 [11q14.1/11q13.4] [t(11;11)(q13;q14)] |
| Fusion : Mitelman | PARVA/POLD3 [11p15.3/11q13.4] [t(11;11)(p15;q13)] |
| Fusion : Mitelman | POLD3/COL3A1 [11q13.4/2q32.2] [t(2;11)(q32;q13)] |
| Fusion : Mitelman | POLD3/TENM4 [11q13.4/11q14.1] [t(11;11)(q13;q14)] |
| Fusion : Mitelman | PPP6R3/POLD3 [11q13.2/11q13.4] [t(11;11)(q13;q13)] |
| Fusion: TCGA_MDACC | INTS4 11q14.1 POLD3 11q13.4 BRCA |
| Fusion: TCGA_MDACC | PARVA 11p15.3 POLD3 11q13.4 BRCA |
| Fusion: TCGA_MDACC | POLD3 11q13.4 ODZ4 LUAD |
| Fusion: TCGA_MDACC | PPP6R3 11q13.2 POLD3 11q13.4 BRCA |
| Fusion Portal | INTS4 11q14.1 POLD3 11q13.4 BRCA |
| Fusion Portal | PARVA 11p15.3 POLD3 11q13.4 BRCA |
| Fusion Portal | POLD3 11q13.4 ODZ4 LUAD |
| Fusion Portal | PPP6R3 11q13.2 POLD3 11q13.4 BRCA |
| Fusion : Quiver | POLD3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | POLD3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | POLD3 |
| dbVar | POLD3 |
| ClinVar | POLD3 |
| 1000_Genomes | POLD3 |
| Exome Variant Server | POLD3 |
| ExAC (Exome Aggregation Consortium) | ENSG00000077514 |
| GNOMAD Browser | ENSG00000077514 |
| Genetic variants : HAPMAP | 10714 |
| Genomic Variants (DGV) | POLD3 [DGVbeta] |
| DECIPHER | POLD3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | POLD3 |
| Mutations |
|---|
| ICGC Data Portal | POLD3 |
| TCGA Data Portal | POLD3 |
| Broad Tumor Portal | POLD3 |
| OASIS Portal | POLD3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | POLD3 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | POLD3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search POLD3 |
| DgiDB (Drug Gene Interaction Database) | POLD3 |
| DoCM (Curated mutations) | POLD3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | POLD3 (select a term) |
| intoGen | POLD3 |
| Cancer3D | POLD3(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 611415 |
| Orphanet | |
| DisGeNET | POLD3 |
| Medgen | POLD3 |
| Genetic Testing Registry | POLD3
|
| NextProt | Q15054 [Medical] |
| TSGene | 10714 |
| GENETests | POLD3 |
| Target Validation | POLD3 |
| Huge Navigator |
POLD3 [HugePedia] |
| snp3D : Map Gene to Disease | 10714 |
| BioCentury BCIQ | POLD3 |
| ClinGen | POLD3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 10714 |
| Chemical/Pharm GKB Gene | PA134868595 |
| Clinical trial | POLD3 |
| Miscellaneous |
|---|
| canSAR (ICR) | POLD3 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 56 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | POLD3 |
| EVEX | POLD3 |
| GoPubMed | POLD3 |
| iHOP | POLD3 |
