Alias (NCBI) | P66 |
| P68 |
| PPP1R128 |
HGNC (Hugo) |
POLD3 |
HGNC Alias symb | P66 |
| KIAA0039 |
| P68 |
| PPP1R128 |
HGNC Alias name | DNA polymerase delta subunit p66 |
| Pol delta C subunit (p66) |
| protein phosphatase 1, regulatory subunit 128 |
HGNC Previous name | polymerase (DNA-directed), delta 3, accessory subunit |
| polymerase (DNA) delta 3, accessory subunit |
LocusID (NCBI) |
10714 |
Atlas_Id |
41771 |
Location |
11q13.4 [Link to chromosome band 11q13] |
Location_base_pair |
Starts at 74592582 and ends at 74643075 bp from pter ( according to hg38-Dec_2013) |
| Nomenclature |
HGNC (Hugo) | POLD3 20932 |
| Cards |
Entrez_Gene (NCBI) | POLD3 DNA polymerase delta 3, accessory subunit |
Aliases | P66; P68; PPP1R128 |
GeneCards (Weizmann) | POLD3 |
Ensembl hg19 (Hinxton) | ENSG00000077514 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000077514 [Gene_View]  ENSG00000077514 [Sequence] chr11:74592582-74643075 [Contig_View] POLD3 [Vega] |
ICGC DataPortal | ENSG00000077514 |
TCGA cBioPortal | POLD3 |
AceView (NCBI) | POLD3 |
Genatlas (Paris) | POLD3 |
SOURCE (Princeton) | POLD3 |
Genetics Home Reference (NIH) | POLD3 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | POLD3 - chr11:74592582-74643075 + 11q13.4 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | POLD3 - 11q13.4 [Description] (hg19-Feb_2009) |
GoldenPath | POLD3 - 11q13.4 [CytoView hg19] POLD3 - 11q13.4 [CytoView hg38] |
ImmunoBase | ENSG00000077514 |
genome Data Viewer NCBI | POLD3 [Mapview hg19] |
OMIM | 611415 |
| Gene and transcription |
Genbank (Entrez) | AK297375 AK302677 AK316301 AK316370 BC020587 |
RefSeq transcript (Entrez) | NM_001363597 NM_006591 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | POLD3 |
Alternative Splicing Gallery | ENSG00000077514 |
Gene Expression | POLD3 [ NCBI-GEO ] POLD3 [ EBI - ARRAY_EXPRESS ]
POLD3 [ SEEK ] POLD3 [ MEM ] |
Gene Expression Viewer (FireBrowse) | POLD3 [ Firebrowse - Broad ] |
Genevisible | Expression of POLD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 10714 |
GTEX Portal (Tissue expression) | POLD3 |
Human Protein Atlas | ENSG00000077514-POLD3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q15054 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q15054 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q15054 |
Splice isoforms : SwissVar | Q15054 |
PhosPhoSitePlus | Q15054 |
Domains : Interpro (EBI) | POLD3 POLD3_sf |
Domain families : Pfam (Sanger) | CDC27 (PF09507) |
Domain families : Pfam (NCBI) | pfam09507 |
Conserved Domain (NCBI) | POLD3 |
Blocks (Seattle) | POLD3 |
PDB (RSDB) | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
PDB Europe | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
PDB (PDBSum) | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
PDB (IMB) | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
Structural Biology KnowledgeBase | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
SCOP (Structural Classification of Proteins) | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
CATH (Classification of proteins structures) | 1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ |
Superfamily | Q15054 |
Human Protein Atlas [tissue] | ENSG00000077514-POLD3 [tissue] |
Peptide Atlas | Q15054 |
HPRD | 11446 |
IPI | IPI00394926 IPI00984074 IPI00983388 IPI00984472 IPI00976030 IPI00982783 IPI00976696 IPI00984780 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q15054 |
IntAct (EBI) | Q15054 |
BioGRID | POLD3 |
STRING (EMBL) | POLD3 |
ZODIAC | POLD3 |
| Ontologies - Pathways |
QuickGO | Q15054 |
Ontology : AmiGO | telomere maintenance DNA synthesis involved in DNA repair DNA-directed DNA polymerase activity protein binding nucleoplasm nucleoplasm cytoplasm DNA strand elongation involved in DNA replication transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling mismatch repair mismatch repair zeta DNA polymerase complex translesion synthesis protein binding, bridging telomere maintenance via semi-conservative replication nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage delta DNA polymerase complex delta DNA polymerase complex DNA biosynthetic process DNA synthesis involved in UV-damage excision repair |
Ontology : EGO-EBI | telomere maintenance DNA synthesis involved in DNA repair DNA-directed DNA polymerase activity protein binding nucleoplasm nucleoplasm cytoplasm DNA strand elongation involved in DNA replication transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling mismatch repair mismatch repair zeta DNA polymerase complex translesion synthesis protein binding, bridging telomere maintenance via semi-conservative replication nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage delta DNA polymerase complex delta DNA polymerase complex DNA biosynthetic process DNA synthesis involved in UV-damage excision repair |
Pathways : KEGG | Purine metabolism Pyrimidine metabolism DNA replication Base excision repair Nucleotide excision repair Mismatch repair Homologous recombination HTLV-I infection |
NDEx Network | POLD3 |
Atlas of Cancer Signalling Network | POLD3 |
Wikipedia pathways | POLD3 |
| Orthology - Evolution |
OrthoDB | 10714 |
GeneTree (enSembl) | ENSG00000077514 |
Phylogenetic Trees/Animal Genes : TreeFam | POLD3 |
HOGENOM | Q15054 |
Homologs : HomoloGene | POLD3 |
Homology/Alignments : Family Browser (UCSC) | POLD3 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | INTS4/POLD3 [11q14.1/11q13.4]   |
Fusion : Mitelman | PARVA/POLD3 [11p15.3/11q13.4]   |
Fusion : Mitelman | POLD3/COL3A1 [11q13.4/2q32.2]   |
Fusion : Mitelman | POLD3/TENM4 [11q13.4/11q14.1]   |
Fusion : Mitelman | PPP6R3/POLD3 [11q13.2/11q13.4]   |
Fusion Portal | INTS4 11q14.1 POLD3 11q13.4 BRCA |
Fusion Portal | PARVA 11p15.3 POLD3 11q13.4 BRCA |
Fusion Portal | POLD3 11q13.4 ODZ4 LUAD |
Fusion Portal | PPP6R3 11q13.2 POLD3 11q13.4 BRCA |
Fusion : Quiver | POLD3 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | POLD3 [hg38] |
dbVar | POLD3 |
ClinVar | POLD3 |
Monarch | POLD3 |
1000_Genomes | POLD3 |
Exome Variant Server | POLD3 |
GNOMAD Browser | ENSG00000077514 |
Varsome Browser | POLD3 |
Genomic Variants (DGV) | POLD3 [DGVbeta] |
DECIPHER | POLD3 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | POLD3 |
| Mutations |
ICGC Data Portal | POLD3 |
TCGA Data Portal | POLD3 |
Broad Tumor Portal | POLD3 |
OASIS Portal | POLD3 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | POLD3 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | POLD3 |
Mutations and Diseases : HGMD | POLD3 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search POLD3 |
DgiDB (Drug Gene Interaction Database) | POLD3 |
DoCM (Curated mutations) | POLD3 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | POLD3 (select a term) |
intoGen | POLD3 |
Cancer3D | POLD3(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 611415 |
Orphanet | |
DisGeNET | POLD3 |
Medgen | POLD3 |
Genetic Testing Registry | POLD3
|
NextProt | Q15054 [Medical] |
GENETests | POLD3 |
Target Validation | POLD3 |
Huge Navigator |
POLD3 [HugePedia] |
ClinGen | POLD3 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | POLD3 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA134868595 |
Pharos | Q15054 |
Clinical trial | POLD3 |
| Miscellaneous |
---|
canSAR (ICR) | POLD3 (select the gene name) |
Harmonizome | POLD3 |
DataMed Index | POLD3 |
| Probes |
---|
| Litterature |
---|
PubMed | 68 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | POLD3 |