POLD3 (DNA polymerase delta 3, accessory subunit)

2003-12-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
P66,P68,PPP1R128
FUSION GENES

Other Information

Locus ID:

NCBI: 10714
MIM: 611415
HGNC: 20932
Ensembl: ENSG00000077514

Variants:

dbSNP: 10714
ClinVar: 10714
TCGA: ENSG00000077514
COSMIC: POLD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077514ENST00000263681Q15054
ENSG00000077514ENST00000263681A0A024R5M8
ENSG00000077514ENST00000524752H0YD46
ENSG00000077514ENST00000527458Q15054
ENSG00000077514ENST00000528481E9PM91
ENSG00000077514ENST00000530511E9PRK3
ENSG00000077514ENST00000531615E9PNC0
ENSG00000077514ENST00000532497Q15054
ENSG00000077514ENST00000532954H0YEX7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Base excision repairKEGGko03410
Nucleotide excision repairKEGGko03420
Mismatch repairKEGGko03430
Homologous recombinationKEGGko03440
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Base excision repairKEGGhsa03410
Nucleotide excision repairKEGGhsa03420
Mismatch repairKEGGhsa03430
Homologous recombinationKEGGhsa03440
Metabolic pathwaysKEGGhsa01100
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
DNA polymerase delta complexKEGGhsa_M00262
DNA polymerase delta complexKEGGM00262
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Removal of the Flap IntermediateREACTOMER-HSA-69166
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
Processive synthesis on the C-strand of the telomereREACTOMER-HSA-174414
Removal of the Flap Intermediate from the C-strandREACTOMER-HSA-174437
DNA ReplicationREACTOMER-HSA-69306
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
Mismatch RepairREACTOMER-HSA-5358508
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)REACTOMER-HSA-5358565
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)REACTOMER-HSA-5358606
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243106112014Break-induced replication repair of damaged forks induces genomic duplications in human cells.149
226347552012Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.119
279847452016RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.88
188185162008X-ray structure of the complex of regulatory subunits of human DNA polymerase delta.44
179320492007Dynamics of human replication factors in the elongation phase of DNA replication.35
228015432012Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.20
221484332012Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.19
269823502016Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.17
271858882016In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.15
240352002013Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.14

Citation

Dessen P

POLD3 (DNA polymerase delta 3, accessory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41771/pold3