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POLD3 (DNA polymerase delta 3, accessory subunit)

Identity

Alias_namespolymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA) delta 3, accessory subunit
Alias_symbol (synonym)P66
KIAA0039
P68
PPP1R128
Other alias
HGNC (Hugo) POLD3
LocusID (NCBI) 10714
Atlas_Id 41771
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 74592530 and ends at 74643060 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
INTS4 (11q14.1) / POLD3 (11q13.4)PARVA (11p15.3) / POLD3 (11q13.4)POLD3 (11q13.4) / COL3A1 (2q32.2)
POLD3 (11q13.4) / TENM4 (11q14.1)PPP6R3 (11q13.2) / POLD3 (11q13.4)INTS4 11q14.1 / POLD3 11q13.4
PARVA 11p15.3 / POLD3 11q13.4POLD3 11q13.4 ODZ4PPP6R3 11q13.2 / POLD3 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(2;11)(q32;q13) POLD3/COL3A1
t(11;11)(p15;q13) PARVA/POLD3
PPP6R3/POLD3 (11q13)
t(11;11)(q13;q14) INTS4/POLD3
t(11;11)(q13;q14) POLD3/TENM4

External links

Nomenclature
HGNC (Hugo)POLD3   20932
Cards
Entrez_Gene (NCBI)POLD3  10714  DNA polymerase delta 3, accessory subunit
AliasesP66; P68; PPP1R128
GeneCards (Weizmann)POLD3
Ensembl hg19 (Hinxton)ENSG00000077514 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077514 [Gene_View]  ENSG00000077514 [Sequence]  chr11:74592530-74643060 [Contig_View]  POLD3 [Vega]
ICGC DataPortalENSG00000077514
TCGA cBioPortalPOLD3
AceView (NCBI)POLD3
Genatlas (Paris)POLD3
WikiGenes10714
SOURCE (Princeton)POLD3
Genetics Home Reference (NIH)POLD3
Genomic and cartography
GoldenPath hg38 (UCSC)POLD3  -     chr11:74592530-74643060 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLD3  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathPOLD3 - 11q13.4 [CytoView hg19]  POLD3 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000077514
Mapping of homologs : NCBIPOLD3 [Mapview hg19]  POLD3 [Mapview hg38]
OMIM611415   
Gene and transcription
Genbank (Entrez)AK297375 AK302677 AK316301 AK316370 BC020587
RefSeq transcript (Entrez)NM_001363597 NM_006591
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLD3
Cluster EST : UnigeneHs.82502 [ NCBI ]
CGAP (NCI)Hs.82502
Alternative Splicing GalleryENSG00000077514
Gene ExpressionPOLD3 [ NCBI-GEO ]   POLD3 [ EBI - ARRAY_EXPRESS ]   POLD3 [ SEEK ]   POLD3 [ MEM ]
Gene Expression Viewer (FireBrowse)POLD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10714
GTEX Portal (Tissue expression)POLD3
Human Protein AtlasENSG00000077514-POLD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15054   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15054  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15054
Splice isoforms : SwissVarQ15054
PhosPhoSitePlusQ15054
Domains : Interpro (EBI)DNA_polymerase_subunit_Cdc27   
Domain families : Pfam (Sanger)CDC27 (PF09507)   
Domain families : Pfam (NCBI)pfam09507   
Conserved Domain (NCBI)POLD3
DMDM Disease mutations10714
Blocks (Seattle)POLD3
PDB (RSDB)1U76    2N1G    3E0J   
PDB Europe1U76    2N1G    3E0J   
PDB (PDBSum)1U76    2N1G    3E0J   
PDB (IMB)1U76    2N1G    3E0J   
Structural Biology KnowledgeBase1U76    2N1G    3E0J   
SCOP (Structural Classification of Proteins)1U76    2N1G    3E0J   
CATH (Classification of proteins structures)1U76    2N1G    3E0J   
SuperfamilyQ15054
Human Protein Atlas [tissue]ENSG00000077514-POLD3 [tissue]
Peptide AtlasQ15054
HPRD11446
IPIIPI00394926   IPI00984074   IPI00983388   IPI00984472   IPI00976030   IPI00982783   IPI00976696   IPI00984780   
Protein Interaction databases
DIP (DOE-UCLA)Q15054
IntAct (EBI)Q15054
FunCoupENSG00000077514
BioGRIDPOLD3
STRING (EMBL)POLD3
ZODIACPOLD3
Ontologies - Pathways
QuickGOQ15054
Ontology : AmiGOtelomere maintenance  DNA synthesis involved in DNA repair  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  cytoplasm  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  DNA damage response, detection of DNA damage  delta DNA polymerase complex  delta DNA polymerase complex  DNA synthesis involved in UV-damage excision repair  
Ontology : EGO-EBItelomere maintenance  DNA synthesis involved in DNA repair  DNA-directed DNA polymerase activity  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  cytoplasm  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  DNA damage response, detection of DNA damage  delta DNA polymerase complex  delta DNA polymerase complex  DNA synthesis involved in UV-damage excision repair  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication    Base excision repair    Nucleotide excision repair    Mismatch repair    Homologous recombination    HTLV-I infection   
NDEx NetworkPOLD3
Atlas of Cancer Signalling NetworkPOLD3
Wikipedia pathwaysPOLD3
Orthology - Evolution
OrthoDB10714
GeneTree (enSembl)ENSG00000077514
Phylogenetic Trees/Animal Genes : TreeFamPOLD3
HOGENOMQ15054
Homologs : HomoloGenePOLD3
Homology/Alignments : Family Browser (UCSC)POLD3
Gene fusions - Rearrangements
Fusion : MitelmanINTS4/POLD3 [11q14.1/11q13.4]  [t(11;11)(q13;q14)]  
Fusion : MitelmanPARVA/POLD3 [11p15.3/11q13.4]  [t(11;11)(p15;q13)]  
Fusion : MitelmanPOLD3/COL3A1 [11q13.4/2q32.2]  [t(2;11)(q32;q13)]  
Fusion : MitelmanPOLD3/TENM4 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanPPP6R3/POLD3 [11q13.2/11q13.4]  [t(11;11)(q13;q13)]  
Fusion PortalINTS4 11q14.1 POLD3 11q13.4 BRCA
Fusion PortalPARVA 11p15.3 POLD3 11q13.4 BRCA
Fusion PortalPOLD3 11q13.4 ODZ4 LUAD
Fusion PortalPPP6R3 11q13.2 POLD3 11q13.4 BRCA
Fusion : QuiverPOLD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLD3
dbVarPOLD3
ClinVarPOLD3
1000_GenomesPOLD3 
Exome Variant ServerPOLD3
ExAC (Exome Aggregation Consortium)ENSG00000077514
GNOMAD BrowserENSG00000077514
Varsome BrowserPOLD3
Genetic variants : HAPMAP10714
Genomic Variants (DGV)POLD3 [DGVbeta]
DECIPHERPOLD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLD3 
Mutations
ICGC Data PortalPOLD3 
TCGA Data PortalPOLD3 
Broad Tumor PortalPOLD3
OASIS PortalPOLD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLD3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLD3
Mutations and Diseases : HGMDPOLD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLD3
DgiDB (Drug Gene Interaction Database)POLD3
DoCM (Curated mutations)POLD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLD3 (select a term)
intoGenPOLD3
Cancer3DPOLD3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611415   
Orphanet
DisGeNETPOLD3
MedgenPOLD3
Genetic Testing Registry POLD3
NextProtQ15054 [Medical]
TSGene10714
GENETestsPOLD3
Target ValidationPOLD3
Huge Navigator POLD3 [HugePedia]
snp3D : Map Gene to Disease10714
BioCentury BCIQPOLD3
ClinGenPOLD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10714
Chemical/Pharm GKB GenePA134868595
Clinical trialPOLD3
Miscellaneous
canSAR (ICR)POLD3 (select the gene name)
DataMed IndexPOLD3
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLD3
EVEXPOLD3
GoPubMedPOLD3
iHOPPOLD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:01:39 CET 2019
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