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POLDIP3 (DNA polymerase delta interacting protein 3)

Identity

Alias_namespolymerase (DNA-directed), delta interacting protein 3
Alias_symbol (synonym)PDIP46
KIAA1649
Other aliasSKAR
HGNC (Hugo) POLDIP3
LocusID (NCBI) 84271
Atlas_Id 72046
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 42583721 and ends at 42614962 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLDIP3 (22q13.2) / CYB5R3 (22q13.2)POLDIP3 (22q13.2) / ITPR2 (12p12.1)POLDIP3 (22q13.2) / POLDIP3 (22q13.2)
POLDIP3 (22q13.2) / TTLL1 (22q13.2)TBC1D22A (22q13.31) / POLDIP3 (22q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(22;22)(q13;q13) TBC1D22A/POLDIP3
t(22;22)(q13;q13) POLDIP3/TTLL1

External links

Nomenclature
HGNC (Hugo)POLDIP3   23782
Cards
Entrez_Gene (NCBI)POLDIP3  84271  DNA polymerase delta interacting protein 3
AliasesPDIP46; SKAR
GeneCards (Weizmann)POLDIP3
Ensembl hg19 (Hinxton)ENSG00000100227 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100227 [Gene_View]  ENSG00000100227 [Sequence]  chr22:42583721-42614962 [Contig_View]  POLDIP3 [Vega]
ICGC DataPortalENSG00000100227
TCGA cBioPortalPOLDIP3
AceView (NCBI)POLDIP3
Genatlas (Paris)POLDIP3
WikiGenes84271
SOURCE (Princeton)POLDIP3
Genetics Home Reference (NIH)POLDIP3
Genomic and cartography
GoldenPath hg38 (UCSC)POLDIP3  -     chr22:42583721-42614962 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLDIP3  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblPOLDIP3 - 22q13.2 [CytoView hg19]  POLDIP3 - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBIPOLDIP3 [Mapview hg19]  POLDIP3 [Mapview hg38]
OMIM611520   
Gene and transcription
Genbank (Entrez)AB055760 AK024626 AK291623 AK291774 AK297532
RefSeq transcript (Entrez)NM_001278657 NM_032311 NM_178136
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLDIP3
Cluster EST : UnigeneHs.505802 [ NCBI ]
CGAP (NCI)Hs.505802
Alternative Splicing GalleryENSG00000100227
Gene ExpressionPOLDIP3 [ NCBI-GEO ]   POLDIP3 [ EBI - ARRAY_EXPRESS ]   POLDIP3 [ SEEK ]   POLDIP3 [ MEM ]
Gene Expression Viewer (FireBrowse)POLDIP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84271
GTEX Portal (Tissue expression)POLDIP3
Human Protein AtlasENSG00000100227-POLDIP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BY77   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BY77  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BY77
Splice isoforms : SwissVarQ9BY77
PhosPhoSitePlusQ9BY77
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)POLDIP3
DMDM Disease mutations84271
Blocks (Seattle)POLDIP3
SuperfamilyQ9BY77
Human Protein Atlas [tissue]ENSG00000100227-POLDIP3 [tissue]
Peptide AtlasQ9BY77
HPRD17875
IPIIPI00440689   IPI00940039   IPI00908753   IPI00440688   IPI00429180   IPI00877685   IPI00878135   
Protein Interaction databases
DIP (DOE-UCLA)Q9BY77
IntAct (EBI)Q9BY77
FunCoupENSG00000100227
BioGRIDPOLDIP3
STRING (EMBL)POLDIP3
ZODIACPOLDIP3
Ontologies - Pathways
QuickGOQ9BY77
Ontology : AmiGO###############################################################################################################################################################################################################################################################                              
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                              
NDEx NetworkPOLDIP3
Atlas of Cancer Signalling NetworkPOLDIP3
Wikipedia pathwaysPOLDIP3
Orthology - Evolution
OrthoDB84271
GeneTree (enSembl)ENSG00000100227
Phylogenetic Trees/Animal Genes : TreeFamPOLDIP3
HOVERGENQ9BY77
HOGENOMQ9BY77
Homologs : HomoloGenePOLDIP3
Homology/Alignments : Family Browser (UCSC)POLDIP3
Gene fusions - Rearrangements
Fusion : QuiverPOLDIP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLDIP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLDIP3
dbVarPOLDIP3
ClinVarPOLDIP3
1000_GenomesPOLDIP3 
Exome Variant ServerPOLDIP3
ExAC (Exome Aggregation Consortium)ENSG00000100227
GNOMAD BrowserENSG00000100227
Varsome BrowserPOLDIP3
Genetic variants : HAPMAP84271
Genomic Variants (DGV)POLDIP3 [DGVbeta]
DECIPHERPOLDIP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLDIP3 
Mutations
ICGC Data PortalPOLDIP3 
TCGA Data PortalPOLDIP3 
Broad Tumor PortalPOLDIP3
OASIS PortalPOLDIP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLDIP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLDIP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLDIP3
DgiDB (Drug Gene Interaction Database)POLDIP3
DoCM (Curated mutations)POLDIP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLDIP3 (select a term)
intoGenPOLDIP3
Cancer3DPOLDIP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611520   
Orphanet
DisGeNETPOLDIP3
MedgenPOLDIP3
Genetic Testing Registry POLDIP3
NextProtQ9BY77 [Medical]
TSGene84271
GENETestsPOLDIP3
Target ValidationPOLDIP3
Huge Navigator POLDIP3 [HugePedia]
snp3D : Map Gene to Disease84271
BioCentury BCIQPOLDIP3
ClinGenPOLDIP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84271
Chemical/Pharm GKB GenePA134899124
Clinical trialPOLDIP3
Miscellaneous
canSAR (ICR)POLDIP3 (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLDIP3
EVEXPOLDIP3
GoPubMedPOLDIP3
iHOPPOLDIP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:24:28 CEST 2018
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