| Nomenclature | | HGNC (Hugo) | POLE 9177 |
| Entrez_Gene (NCBI) | POLE 5426 polymerase (DNA directed), epsilon, catalytic subunit |
| Cards | | GeneCards (Weizmann) | POLE |
| Ensembl (Hinxton) | ENSG00000177084 [Gene_View] chr12:133200348-133263945 [Contig_View] POLE [Vega] |
| AceView (NCBI) | POLE |
| Genatlas (Paris) | POLE |
| SOURCE (Stanford) | NM_006231 |
| Genomic and cartography | | GoldenPath (UCSC) | POLE - 12q24.33 chr12:133200348-133263945 - 12q24.33 [Description] (hg19-Feb_2009) |
| Ensembl | POLE - 12q24.33 [CytoView] |
| Mapping of homologs : NCBI | POLE [Mapview] |
| OMIM | 174762 |
| Gene and transcription |
| Genbank (Entrez) | AF128542 AF128544 AK025087 AK093003 AK128248 |
| RefSeq transcript (SRS) | NM_006231 |
| RefSeq transcript (Entrez) | NM_006231 |
| RefSeq genomic (SRS) | AC_000144 NC_000012 NC_018923 NT_024477 NW_001838067 NW_004078076 |
| RefSeq genomic (Entrez) | AC_000144 NC_000012 NC_018923 NT_024477 NW_001838067 NW_004078076 |
| Consensus coding sequences : CCDS (NCBI) | POLE |
| Cluster EST : Unigene | Hs.524871 [ SRS ] Hs.524871 [ NCBI ] |
| CGAP (NCI) | Hs.524871 |
| Alternative Splicing : Fast-db (Paris) | GSHG0007942 |
| Alternative Splicing Gallery | ENSG00000177084 |
| Gene Expression | POLE [ NCBI-GEO ] POLE [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q07864 (SRS) Q07864 (Uniprot) |
| NextProt | Q07864 |
| With graphics : InterPro | Q07864 |
| Splice isoforms : SwissVar | Q07864(Swissvar) |
| Domains : Interpro (SRS) | DNA-dir_DNA_pol_B DNA-dir_DNA_pol_B_exonuc DNA-dir_DNA_pol_B_multi_dom DNA_pol_e_suA_C RNaseH-like_dom |
| Domains : Interpro (EBI) | DNA-dir_DNA_pol_B DNA-dir_DNA_pol_B_exonuc DNA-dir_DNA_pol_B_multi_dom DNA_pol_e_suA_C RNaseH-like_dom |
| Related proteins : CluSTr | Q07864 |
| Domain families : Pfam (SRS) | DNA_pol_B (PF00136) DNA_pol_B_exo1 (PF03104) DUF1744 (PF08490) |
| Domain families : Pfam (Sanger) | DNA_pol_B (PF00136) DNA_pol_B_exo1 (PF03104) DUF1744 (PF08490) |
| Domain families : Pfam (NCBI) | pfam00136 pfam03104 pfam08490 |
| Domain families : Smart (EMBL) | POLBc (SM00486) |
| DMDM | 5426 |
| Blocks (Seattle) | Q07864 |
| Human Protein Atlas | ENSG00000177084 |
| HPRD | 07177 |
| IPI | IPI00939602 IPI00940894 IPI01019102 IPI00000898 IPI00797203 IPI00744598 IPI00790334 IPI01012998 IPI01013454 IPI01013828 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q07864 |
| IntAct (EBI) | Q07864 |
| FunCoup | ENSG00000177084 |
| REACTOME | POLE |
| Protein Interaction Database | 5426 |
| BioGRID | POLE |
| InParanoid | Q07864 |
| Interologous Interaction database | Q07864 |
| IntegromeDB | POLE |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | POLE |
| SNP (GeneSNP Utah) | POLE |
| SNP : HGBase | POLE |
| Genetic variants : HAPMAP | POLE |
| Somatic Mutations in Cancer : COSMIC | POLE |
| CONAN: Copy Number Analysis | POLE |
| Mutations and Diseases : HGMD | POLE |
| OMIM | 174762 |
| GENETests | 174762 |
| Disease Genetic Association | POLE |
| Huge Navigator |
POLE [HugePedia] POLE [HugeCancerGEM] |
| Genomic Variants | POLE POLE [DGVbeta] |
| snp3D : Map Gene to Disease | 5426 |
| General knowledge |
|---|
| Homologs : HomoloGene | POLE |
| Homology/Alignments : Family Browser (UCSC) | POLE |
| Phylogenetic Trees/Animal Genes : TreeFam | POLE |
| Catalytic activity : Enzyme | 2.7.7.7 [ Enzyme-Expasy ] 2.7.7.7 [ Enzyme-SRS ] 2.7.7.7 [ IntEnz-EBI ] 2.7.7.7 [ BRENDA ] 2.7.7.7 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 5426 |
| Chemical/Pharm GKB Gene | PA277 |
| Clinical trial | POLE |
| Cancer Resource (Charite) | ENSG00000177084 |
| Ontology : AmiGO | G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle S phase of mitotic cell cycle nucleotide binding M/G1 transition of mitotic cell cycle mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair in utero embryonic development DNA binding chromatin binding DNA-directed DNA polymerase activity nucleus nucleoplasm DNA replication DNA replication initiation DNA repair transcription-coupled nucleotide-excision repair base-excision repair, gap-filling nucleotide-excision repair nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling zinc ion binding epsilon DNA polymerase complex telomere maintenance via semi-conservative replication metal ion binding 4 iron, 4 sulfur cluster binding |
| Ontology : EGO-EBI | G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle S phase of mitotic cell cycle nucleotide binding M/G1 transition of mitotic cell cycle mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair in utero embryonic development DNA binding chromatin binding DNA-directed DNA polymerase activity nucleus nucleoplasm DNA replication DNA replication initiation DNA repair transcription-coupled nucleotide-excision repair base-excision repair, gap-filling nucleotide-excision repair nucleotide-excision repair, DNA gap filling nucleotide-excision repair, DNA gap filling zinc ion binding epsilon DNA polymerase complex telomere maintenance via semi-conservative replication metal ion binding 4 iron, 4 sulfur cluster binding |
| Pathways : KEGG | DNA polymerasePurine metabolismPyrimidine metabolism |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 53 Pubmed reference(s) in Entrez |
| PubGene | POLE |
| iHOP | POLE |
