Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

POLE3 (DNA polymerase epsilon 3, accessory subunit)

Identity

Alias_namespolymerase (DNA directed), epsilon 3 (p17 subunit)
polymerase (DNA) epsilon 3, accessory subunit
Alias_symbol (synonym)CHRAC17
Ybl1
p17
CHARAC17
Other aliasYBL1
HGNC (Hugo) POLE3
LocusID (NCBI) 54107
Atlas_Id 43418
Location 9q32  [Link to chromosome band 9q32]
Location_base_pair Starts at 113407239 and ends at 113410749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
POLE3 (9q32) / LRRC58 (3q13.33)SBDS (7q11.21) / POLE3 (9q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLE3   13546
Cards
Entrez_Gene (NCBI)POLE3  54107  DNA polymerase epsilon 3, accessory subunit
AliasesCHARAC17; CHRAC17; YBL1; p17
GeneCards (Weizmann)POLE3
Ensembl hg19 (Hinxton)ENSG00000148229 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148229 [Gene_View]  chr9:113407239-113410749 [Contig_View]  POLE3 [Vega]
ICGC DataPortalENSG00000148229
TCGA cBioPortalPOLE3
AceView (NCBI)POLE3
Genatlas (Paris)POLE3
WikiGenes54107
SOURCE (Princeton)POLE3
Genetics Home Reference (NIH)POLE3
Genomic and cartography
GoldenPath hg38 (UCSC)POLE3  -     chr9:113407239-113410749 -  9q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLE3  -     9q32   [Description]    (hg19-Feb_2009)
EnsemblPOLE3 - 9q32 [CytoView hg19]  POLE3 - 9q32 [CytoView hg38]
Mapping of homologs : NCBIPOLE3 [Mapview hg19]  POLE3 [Mapview hg38]
OMIM607267   
Gene and transcription
Genbank (Entrez)AF070640 AF226077 AK074629 AK074762 AK074782
RefSeq transcript (Entrez)NM_001278255 NM_017443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLE3
Cluster EST : UnigeneHs.108112 [ NCBI ]
CGAP (NCI)Hs.108112
Alternative Splicing GalleryENSG00000148229
Gene ExpressionPOLE3 [ NCBI-GEO ]   POLE3 [ EBI - ARRAY_EXPRESS ]   POLE3 [ SEEK ]   POLE3 [ MEM ]
Gene Expression Viewer (FireBrowse)POLE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54107
GTEX Portal (Tissue expression)POLE3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRF9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRF9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRF9
Splice isoforms : SwissVarQ9NRF9
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
PhosPhoSitePlusQ9NRF9
Domains : Interpro (EBI)CBFA_NFYB_domain    Histone-fold   
Domain families : Pfam (Sanger)CBFD_NFYB_HMF (PF00808)   
Domain families : Pfam (NCBI)pfam00808   
Conserved Domain (NCBI)POLE3
DMDM Disease mutations54107
Blocks (Seattle)POLE3
SuperfamilyQ9NRF9
Human Protein AtlasENSG00000148229
Peptide AtlasQ9NRF9
HPRD06274
IPIIPI00010141   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRF9
IntAct (EBI)Q9NRF9
FunCoupENSG00000148229
BioGRIDPOLE3
STRING (EMBL)POLE3
ZODIACPOLE3
Ontologies - Pathways
QuickGOQ9NRF9
Ontology : AmiGOG1/S transition of mitotic cell cycle  telomere maintenance via recombination  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  DNA replication  DNA replication initiation  epsilon DNA polymerase complex  histone H3 acetylation  protein heterodimerization activity  DNA biosynthetic process  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  telomere maintenance via recombination  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  DNA replication  DNA replication initiation  epsilon DNA polymerase complex  histone H3 acetylation  protein heterodimerization activity  DNA biosynthetic process  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication    Base excision repair    Nucleotide excision repair    HTLV-I infection   
NDEx NetworkPOLE3
Atlas of Cancer Signalling NetworkPOLE3
Wikipedia pathwaysPOLE3
Orthology - Evolution
OrthoDB54107
GeneTree (enSembl)ENSG00000148229
Phylogenetic Trees/Animal Genes : TreeFamPOLE3
HOVERGENQ9NRF9
HOGENOMQ9NRF9
Homologs : HomoloGenePOLE3
Homology/Alignments : Family Browser (UCSC)POLE3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLE3
dbVarPOLE3
ClinVarPOLE3
1000_GenomesPOLE3 
Exome Variant ServerPOLE3
ExAC (Exome Aggregation Consortium)POLE3 (select the gene name)
Genetic variants : HAPMAP54107
Genomic Variants (DGV)POLE3 [DGVbeta]
DECIPHERPOLE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLE3 
Mutations
ICGC Data PortalPOLE3 
TCGA Data PortalPOLE3 
Broad Tumor PortalPOLE3
OASIS PortalPOLE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLE3
DgiDB (Drug Gene Interaction Database)POLE3
DoCM (Curated mutations)POLE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLE3 (select a term)
intoGenPOLE3
Cancer3DPOLE3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607267   
Orphanet
MedgenPOLE3
Genetic Testing Registry POLE3
NextProtQ9NRF9 [Medical]
TSGene54107
GENETestsPOLE3
Target ValidationPOLE3
Huge Navigator POLE3 [HugePedia]
snp3D : Map Gene to Disease54107
BioCentury BCIQPOLE3
ClinGenPOLE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54107
Chemical/Pharm GKB GenePA33499
Clinical trialPOLE3
Miscellaneous
canSAR (ICR)POLE3 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLE3
EVEXPOLE3
GoPubMedPOLE3
iHOPPOLE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:50:13 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.