Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

POLG (polymerase (DNA) gamma, catalytic subunit)

Identity

Other namesMDP1
MIRAS
MTDPS4A
MTDPS4B
PEO
POLG1
POLGA
SANDO
SCAE
HGNC (Hugo) POLG
LocusID (NCBI) 5428
Atlas_Id 43420
Location 15q26.1
Location_base_pair Starts at 89859536 and ends at 89878026 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
POLG (15q26.1) / POLG (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLG   9179
Cards
Entrez_Gene (NCBI)POLG  5428  polymerase (DNA) gamma, catalytic subunit
GeneCards (Weizmann)POLG
Ensembl hg19 (Hinxton)ENSG00000140521 [Gene_View]  chr15:89859536-89878026 [Contig_View]  POLG [Vega]
Ensembl hg38 (Hinxton)ENSG00000140521 [Gene_View]  chr15:89859536-89878026 [Contig_View]  POLG [Vega]
ICGC DataPortalENSG00000140521
TCGA cBioPortalPOLG
AceView (NCBI)POLG
Genatlas (Paris)POLG
WikiGenes5428
SOURCE (Princeton)POLG
Genomic and cartography
GoldenPath hg19 (UCSC)POLG  -     chr15:89859536-89878026 -  15q26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLG  -     15q26.1   [Description]    (hg38-Dec_2013)
EnsemblPOLG - 15q26.1 [CytoView hg19]  POLG - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIPOLG [Mapview hg19]  POLG [Mapview hg38]
OMIM157640   174763   203700   258450   603041   607459   613662   
Gene and transcription
Genbank (Entrez)AK130624 AK291281 AL110092 AW015913 BC042571
RefSeq transcript (Entrez)NM_001126131 NM_002693
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_008218 NT_010194 NW_004929399
Consensus coding sequences : CCDS (NCBI)POLG
Cluster EST : UnigeneHs.706868 [ NCBI ]
CGAP (NCI)Hs.706868
Alternative Splicing GalleryENSG00000140521
Gene ExpressionPOLG [ NCBI-GEO ]   POLG [ EBI - ARRAY_EXPRESS ]   POLG [ SEEK ]   POLG [ MEM ]
Gene Expression Viewer (FireBrowse)POLG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5428
GTEX Portal (Tissue expression)POLG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54098 (Uniprot)
NextProtP54098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54098
Splice isoforms : SwissVarP54098 (Swissvar)
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
PhosPhoSitePlusP54098
Domaine pattern : Prosite (Expaxy)DNA_POLYMERASE_A (PS00447)   
Domains : Interpro (EBI)DNA-dir_DNA_pol_A_CS    DNA-dir_DNA_pol_A_mt    DNA-dir_DNA_pol_A_palm_dom    RNaseH-like_dom   
Domain families : Pfam (Sanger)DNA_pol_A (PF00476)   
Domain families : Pfam (NCBI)pfam00476   
Domain families : Smart (EMBL)POLAc (SM00482)  
DMDM Disease mutations5428
Blocks (Seattle)POLG
PDB (SRS)3IKM    4ZTU    4ZTZ    5C53   
PDB (PDBSum)3IKM    4ZTU    4ZTZ    5C53   
PDB (IMB)3IKM    4ZTU    4ZTZ    5C53   
PDB (RSDB)3IKM    4ZTU    4ZTZ    5C53   
Structural Biology KnowledgeBase3IKM    4ZTU    4ZTZ    5C53   
SCOP (Structural Classification of Proteins)3IKM    4ZTU    4ZTZ    5C53   
CATH (Classification of proteins structures)3IKM    4ZTU    4ZTZ    5C53   
SuperfamilyP54098
Human Protein AtlasENSG00000140521
Peptide AtlasP54098
HPRD01438
IPIIPI00004317   IPI00982072   IPI00980593   IPI00981195   IPI00979973   IPI00983259   
Protein Interaction databases
DIP (DOE-UCLA)P54098
IntAct (EBI)P54098
FunCoupENSG00000140521
BioGRIDPOLG
STRING (EMBL)POLG
ZODIACPOLG
Ontologies - Pathways
QuickGOP54098
Ontology : AmiGOprotease binding  DNA binding  chromatin binding  DNA-directed DNA polymerase activity  protein binding  mitochondrion  gamma DNA polymerase complex  DNA metabolic process  DNA-dependent DNA replication  mitochondrial DNA replication  base-excision repair, gap-filling  aging  3'-5' exonuclease activity  response to light stimulus  response to gamma radiation  mitochondrial nucleoid  terminal bouton  protein complex  response to hyperoxia  extracellular exosome  cellular response to glucose stimulus  DNA biosynthetic process  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIprotease binding  DNA binding  chromatin binding  DNA-directed DNA polymerase activity  protein binding  mitochondrion  gamma DNA polymerase complex  DNA metabolic process  DNA-dependent DNA replication  mitochondrial DNA replication  base-excision repair, gap-filling  aging  3'-5' exonuclease activity  response to light stimulus  response to gamma radiation  mitochondrial nucleoid  terminal bouton  protein complex  response to hyperoxia  extracellular exosome  cellular response to glucose stimulus  DNA biosynthetic process  nucleic acid phosphodiester bond hydrolysis  
NDEx Network
Atlas of Cancer Signalling NetworkPOLG
Wikipedia pathwaysPOLG
Orthology - Evolution
OrthoDB5428
GeneTree (enSembl)ENSG00000140521
Phylogenetic Trees/Animal Genes : TreeFamPOLG
Homologs : HomoloGenePOLG
Homology/Alignments : Family Browser (UCSC)POLG
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPOLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLG
dbVarPOLG
ClinVarPOLG
1000_GenomesPOLG 
Exome Variant ServerPOLG
ExAC (Exome Aggregation Consortium)POLG (select the gene name)
Genetic variants : HAPMAP5428
Genomic Variants (DGV)POLG [DGVbeta]
Mutations
ICGC Data PortalPOLG 
TCGA Data PortalPOLG 
Broad Tumor PortalPOLG
OASIS PortalPOLG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POLG
DgiDB (Drug Gene Interaction Database)POLG
DoCM (Curated mutations)POLG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLG (select a term)
intoGenPOLG
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:89859536-89878026  ENSG00000140521
CONAN: Copy Number AnalysisPOLG 
Mutations and Diseases : HGMDPOLG
OMIM157640    174763    203700    258450    603041    607459    613662   
MedgenPOLG
Genetic Testing Registry POLG
NextProtP54098 [Medical]
TSGene5428
GENETestsPOLG
Huge Navigator POLG [HugePedia]
snp3D : Map Gene to Disease5428
BioCentury BCIQPOLG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5428
Chemical/Pharm GKB GenePA33500
Clinical trialPOLG
Miscellaneous
canSAR (ICR)POLG (select the gene name)
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLG
EVEXPOLG
GoPubMedPOLG
iHOPPOLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 19:01:06 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.