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POLG2 (polymerase (DNA) gamma 2, accessory subunit)

Identity

Alias_namespolymerase (DNA directed), gamma 2, accessory subunit
polymerase (DNA) gamma 2, accessory subunit
Alias_symbol (synonym)MTPOLB
HP55
Other aliasPEOA4
POLB
POLG-BETA
POLGB
HGNC (Hugo) POLG2
LocusID (NCBI) 11232
Atlas_Id 41775
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 62473902 and ends at 62493184 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
POLG2 (17q23.3) / AARS (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLG2   9180
Cards
Entrez_Gene (NCBI)POLG2  11232  polymerase (DNA) gamma 2, accessory subunit
AliasesHP55; MTPOLB; PEOA4; POLB; 
POLG-BETA; POLGB
GeneCards (Weizmann)POLG2
Ensembl hg19 (Hinxton)ENSG00000256525 [Gene_View]  chr17:62473902-62493184 [Contig_View]  POLG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000256525 [Gene_View]  chr17:62473902-62493184 [Contig_View]  POLG2 [Vega]
ICGC DataPortalENSG00000256525
TCGA cBioPortalPOLG2
AceView (NCBI)POLG2
Genatlas (Paris)POLG2
WikiGenes11232
SOURCE (Princeton)POLG2
Genetics Home Reference (NIH)POLG2
Genomic and cartography
GoldenPath hg19 (UCSC)POLG2  -     chr17:62473902-62493184 -  17q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLG2  -     17q23.3   [Description]    (hg38-Dec_2013)
EnsemblPOLG2 - 17q23.3 [CytoView hg19]  POLG2 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIPOLG2 [Mapview hg19]  POLG2 [Mapview hg38]
OMIM604983   610131   
Gene and transcription
Genbank (Entrez)AF142992 AF177201 AF184344 AK307801 BC000913
RefSeq transcript (Entrez)NM_007215
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_013029 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)POLG2
Cluster EST : UnigeneHs.437009 [ NCBI ]
CGAP (NCI)Hs.437009
Alternative Splicing GalleryENSG00000256525
Gene ExpressionPOLG2 [ NCBI-GEO ]   POLG2 [ EBI - ARRAY_EXPRESS ]   POLG2 [ SEEK ]   POLG2 [ MEM ]
Gene Expression Viewer (FireBrowse)POLG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11232
GTEX Portal (Tissue expression)POLG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHN1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHN1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHN1
Splice isoforms : SwissVarQ9UHN1
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
PhosPhoSitePlusQ9UHN1
Domains : Interpro (EBI)Anticodon-bd    Gly-tRNA_synthase/POLG2    POLG2   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)   
Domain families : Pfam (NCBI)pfam03129   
Conserved Domain (NCBI)POLG2
DMDM Disease mutations11232
Blocks (Seattle)POLG2
PDB (SRS)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
PDB (PDBSum)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
PDB (IMB)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
PDB (RSDB)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
Structural Biology KnowledgeBase2G4C    3IKL    3IKM    4ZTU    4ZTZ   
SCOP (Structural Classification of Proteins)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
CATH (Classification of proteins structures)2G4C    3IKL    3IKM    4ZTU    4ZTZ   
SuperfamilyQ9UHN1
Human Protein AtlasENSG00000256525
Peptide AtlasQ9UHN1
HPRD09228
IPIIPI00033486   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHN1
IntAct (EBI)Q9UHN1
FunCoupENSG00000256525
BioGRIDPOLG2
STRING (EMBL)POLG2
ZODIACPOLG2
Ontologies - Pathways
QuickGOQ9UHN1
Ontology : AmiGOmitochondrial chromosome  in utero embryonic development  DNA binding  DNA-directed DNA polymerase activity  glycine-tRNA ligase activity  protein binding  mitochondrial matrix  DNA replication  DNA-dependent DNA replication  DNA repair  glycyl-tRNA aminoacylation  mitochondrion organization  respiratory electron transport chain  mitochondrial DNA metabolic process  mitochondrial nucleoid  identical protein binding  extracellular exosome  mitochondrion morphogenesis  DNA biosynthetic process  
Ontology : EGO-EBImitochondrial chromosome  in utero embryonic development  DNA binding  DNA-directed DNA polymerase activity  glycine-tRNA ligase activity  protein binding  mitochondrial matrix  DNA replication  DNA-dependent DNA replication  DNA repair  glycyl-tRNA aminoacylation  mitochondrion organization  respiratory electron transport chain  mitochondrial DNA metabolic process  mitochondrial nucleoid  identical protein binding  extracellular exosome  mitochondrion morphogenesis  DNA biosynthetic process  
NDEx NetworkPOLG2
Atlas of Cancer Signalling NetworkPOLG2
Wikipedia pathwaysPOLG2
Orthology - Evolution
OrthoDB11232
GeneTree (enSembl)ENSG00000256525
Phylogenetic Trees/Animal Genes : TreeFamPOLG2
HOVERGENQ9UHN1
HOGENOMQ9UHN1
Homologs : HomoloGenePOLG2
Homology/Alignments : Family Browser (UCSC)POLG2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLG2
dbVarPOLG2
ClinVarPOLG2
1000_GenomesPOLG2 
Exome Variant ServerPOLG2
ExAC (Exome Aggregation Consortium)POLG2 (select the gene name)
Genetic variants : HAPMAP11232
Genomic Variants (DGV)POLG2 [DGVbeta]
DECIPHER (Syndromes)17:62473902-62493184  ENSG00000256525
CONAN: Copy Number AnalysisPOLG2 
Mutations
ICGC Data PortalPOLG2 
TCGA Data PortalPOLG2 
Broad Tumor PortalPOLG2
OASIS PortalPOLG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POLG2
DgiDB (Drug Gene Interaction Database)POLG2
DoCM (Curated mutations)POLG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLG2 (select a term)
intoGenPOLG2
Cancer3DPOLG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604983    610131   
Orphanet19796   
MedgenPOLG2
Genetic Testing Registry POLG2
NextProtQ9UHN1 [Medical]
TSGene11232
GENETestsPOLG2
Huge Navigator POLG2 [HugePedia]
snp3D : Map Gene to Disease11232
BioCentury BCIQPOLG2
ClinGenPOLG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11232
Chemical/Pharm GKB GenePA33501
Clinical trialPOLG2
Miscellaneous
canSAR (ICR)POLG2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLG2
EVEXPOLG2
GoPubMedPOLG2
iHOPPOLG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:59 CEST 2017

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