POLI (DNA polymerase iota)

2003-02-01  

Identity

HGNC
POLI
LOCATION
18q21.2
LOCUSID
11201
ALIAS
RAD30B,RAD3OB,eta2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11201
MIM: 605252
HGNC: 9182
Ensembl: ENSG00000101751

Variants:

dbSNP: 11201
ClinVar: 11201
TCGA: ENSG00000101751
COSMIC: POLI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101751ENST00000217800X6R2I3
ENSG00000101751ENST00000406285J3KQ09
ENSG00000101751ENST00000577612J3QR36
ENSG00000101751ENST00000579434J3KSW2
ENSG00000101751ENST00000579534Q9UNA4
ENSG00000101751ENST00000579823J3KTM8
ENSG00000101751ENST00000580880J3KRG0
ENSG00000101751ENST00000581950J3KRS8
ENSG00000101751ENST00000583136J3KTN3
ENSG00000101751ENST00000585023J3QQZ8

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by POLIREACTOMER-HSA-5656121
Termination of translesion DNA synthesisREACTOMER-HSA-5656169

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163572612005Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.304
152545432004Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.134
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
167635562006Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin.85
191163882009A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.63
124103152002Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.57
153138972004Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis.54
176092172007Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese.49
156093172005Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.45
194402062009Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota.42

Citation

Dessen P

POLI (DNA polymerase iota)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41776/poli