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POLM (DNA polymerase mu)

Identity

Alias (NCBI)Pol Mu
Tdt-N
HGNC (Hugo) POLM
HGNC Alias symbTdt-N
HGNC Alias namePol iota
HGNC Previous namepolymerase (DNA directed), mu
 polymerase (DNA) mu
LocusID (NCBI) 27434
Atlas_Id 43421
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44072062 and ends at 44082530 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)POLM   9185
Cards
Entrez_Gene (NCBI)POLM    DNA polymerase mu
AliasesPol; Tdt-N
GeneCards (Weizmann)POLM
Ensembl hg19 (Hinxton)ENSG00000122678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122678 [Gene_View]  ENSG00000122678 [Sequence]  chr7:44072062-44082530 [Contig_View]  POLM [Vega]
ICGC DataPortalENSG00000122678
TCGA cBioPortalPOLM
AceView (NCBI)POLM
Genatlas (Paris)POLM
SOURCE (Princeton)POLM
Genetics Home Reference (NIH)POLM
Genomic and cartography
GoldenPath hg38 (UCSC)POLM  -     chr7:44072062-44082530 -  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLM  -     7p13   [Description]    (hg19-Feb_2009)
GoldenPathPOLM - 7p13 [CytoView hg19]  POLM - 7p13 [CytoView hg38]
ImmunoBaseENSG00000122678
Genome Data Viewer NCBIPOLM [Mapview hg19]  
OMIM606344   
Gene and transcription
Genbank (Entrez)AA917987 AF176097 AJ131891 AK023002 AK092801
RefSeq transcript (Entrez)NM_001284330 NM_001284331 NM_001362683 NM_013284
Consensus coding sequences : CCDS (NCBI)POLM
Gene ExpressionPOLM [ NCBI-GEO ]   POLM [ EBI - ARRAY_EXPRESS ]   POLM [ SEEK ]   POLM [ MEM ]
Gene Expression Viewer (FireBrowse)POLM [ Firebrowse - Broad ]
GenevisibleExpression of POLM in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27434
GTEX Portal (Tissue expression)POLM
Human Protein AtlasENSG00000122678-POLM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NP87   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NP87  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NP87
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NP87
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    DNA_POLYMERASE_X (PS00522)   
Domains : Interpro (EBI)BRCT_dom    BRCT_dom_sf    DNA-dir_DNA_pol_X    DNA/RNApol_mu    DNA_pol-X_BS    DNA_pol_b-like_N    DNA_pol_B_palm_palm    DNA_pol_lambd_fingers_domain    DNA_pol_lamdba_lyase_dom_sf    DNA_Pol_thumb_sf    DNA_pol_X    NT_sf    PolB_thumb    TdT/Mu   
Domain families : Pfam (Sanger)DNA_pol_B_palm (PF14792)    DNA_pol_B_thumb (PF14791)    DNA_pol_lambd_f (PF10391)    HHH_8 (PF14716)   
Domain families : Pfam (NCBI)pfam14792    pfam14791    pfam10391    pfam14716   
Domain families : Smart (EMBL)POLXc (SM00483)  
Conserved Domain (NCBI)POLM
PDB (RSDB)2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
PDB Europe2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
PDB (PDBSum)2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
PDB (IMB)2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
Structural Biology KnowledgeBase2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
SCOP (Structural Classification of Proteins)2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
CATH (Classification of proteins structures)2DUN    2HTF    4LZD    4LZG    4M04    4M0A    4YCX    4YD1    4YD2    5TWP    5TWQ    5TWR    5TWS    5TXX    5TXZ    5TYB    5TYC    5TYD    5TYE    5TYF    5TYG    5TYU    5TYV    5TYW    5TYX    5TYY    5TYZ    5VZ7    5VZ8    5VZ9    5VZA    5VZB    5VZC    5VZD    5VZE    5VZF    5VZG    5VZH    5VZI    5W4F    5ZLC    6AEC    6AEH    6AK5    6AK6    6AK8    6AK9    6AKH    6IPD    6IPE    6IPF    6IPG    6IPH    6IPI    6IPJ    6IPK    6IPL    6IPM    6IPN    6P1M    6P1N    6P1O    6P1P    6P1Q    6P1R    6P1S    6P1T    6P1U    6P1V    6P1W    6WIC    6WID    6WIE   
SuperfamilyQ9NP87
AlphaFold pdb e-kbQ9NP87   
Human Protein Atlas [tissue]ENSG00000122678-POLM [tissue]
HPRD16208
Protein Interaction databases
DIP (DOE-UCLA)Q9NP87
IntAct (EBI)Q9NP87
BioGRIDPOLM
STRING (EMBL)POLM
ZODIACPOLM
Ontologies - Pathways
QuickGOQ9NP87
Ontology : AmiGODNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  DNA recombination  metal ion binding  DNA biosynthetic process  
Ontology : EGO-EBIDNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  DNA recombination  metal ion binding  DNA biosynthetic process  
Pathways : KEGGNon-homologous end-joining   
NDEx NetworkPOLM
Atlas of Cancer Signalling NetworkPOLM
Wikipedia pathwaysPOLM
Orthology - Evolution
OrthoDB27434
GeneTree (enSembl)ENSG00000122678
Phylogenetic Trees/Animal Genes : TreeFamPOLM
Homologs : HomoloGenePOLM
Homology/Alignments : Family Browser (UCSC)POLM
Gene fusions - Rearrangements
Fusion : QuiverPOLM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLM
dbVarPOLM
ClinVarPOLM
MonarchPOLM
1000_GenomesPOLM 
Exome Variant ServerPOLM
GNOMAD BrowserENSG00000122678
Varsome BrowserPOLM
ACMGPOLM variants
VarityQ9NP87
Genomic Variants (DGV)POLM [DGVbeta]
DECIPHERPOLM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLM 
Mutations
ICGC Data PortalPOLM 
TCGA Data PortalPOLM 
Broad Tumor PortalPOLM
OASIS PortalPOLM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLM
Mutations and Diseases : HGMDPOLM
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPOLM
DgiDB (Drug Gene Interaction Database)POLM
DoCM (Curated mutations)POLM
CIViC (Clinical Interpretations of Variants in Cancer)POLM
Cancer3DPOLM
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606344   
Orphanet
DisGeNETPOLM
MedgenPOLM
Genetic Testing Registry POLM
NextProtQ9NP87 [Medical]
GENETestsPOLM
Target ValidationPOLM
Huge Navigator POLM [HugePedia]
ClinGenPOLM
Clinical trials, drugs, therapy
MyCancerGenomePOLM
Protein Interactions : CTDPOLM
Pharm GKB GenePA33505
PharosQ9NP87
Clinical trialPOLM
Miscellaneous
canSAR (ICR)POLM
HarmonizomePOLM
DataMed IndexPOLM
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPOLM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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