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POLR1E (RNA polymerase I subunit E)

Identity

Alias_namesPRAF1
polymerase (RNA) I associated factor 1
polymerase (RNA) I polypeptide E, 53kDa
Alias_symbol (synonym)FLJ13390
PAF53
FLJ13970
Other alias
HGNC (Hugo) POLR1E
LocusID (NCBI) 64425
Atlas_Id 72050
Location 9p13.2  [Link to chromosome band 9p13]
Location_base_pair Starts at 37485935 and ends at 37503697 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZCCHC7 (9p13.2) / POLR1E (9p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR1E   17631
Cards
Entrez_Gene (NCBI)POLR1E  64425  RNA polymerase I subunit E
AliasesPAF53; PRAF1
GeneCards (Weizmann)POLR1E
Ensembl hg19 (Hinxton)ENSG00000137054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137054 [Gene_View]  chr9:37485935-37503697 [Contig_View]  POLR1E [Vega]
ICGC DataPortalENSG00000137054
TCGA cBioPortalPOLR1E
AceView (NCBI)POLR1E
Genatlas (Paris)POLR1E
WikiGenes64425
SOURCE (Princeton)POLR1E
Genetics Home Reference (NIH)POLR1E
Genomic and cartography
GoldenPath hg38 (UCSC)POLR1E  -     chr9:37485935-37503697 +  9p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR1E  -     9p13.2   [Description]    (hg19-Feb_2009)
EnsemblPOLR1E - 9p13.2 [CytoView hg19]  POLR1E - 9p13.2 [CytoView hg38]
Mapping of homologs : NCBIPOLR1E [Mapview hg19]  POLR1E [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK023452 AK024032 AK091294 AK125471 AK225050
RefSeq transcript (Entrez)NM_001282766 NM_022490
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR1E
Cluster EST : UnigeneHs.733126 [ NCBI ]
CGAP (NCI)Hs.733126
Alternative Splicing GalleryENSG00000137054
Gene ExpressionPOLR1E [ NCBI-GEO ]   POLR1E [ EBI - ARRAY_EXPRESS ]   POLR1E [ SEEK ]   POLR1E [ MEM ]
Gene Expression Viewer (FireBrowse)POLR1E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64425
GTEX Portal (Tissue expression)POLR1E
Human Protein AtlasENSG00000137054-POLR1E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZS1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZS1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZS1
Splice isoforms : SwissVarQ9GZS1
PhosPhoSitePlusQ9GZS1
Domains : Interpro (EBI)RNA_pol-assoc_fac_A49-like   
Domain families : Pfam (Sanger)RNA_pol_I_A49 (PF06870)   
Domain families : Pfam (NCBI)pfam06870   
Conserved Domain (NCBI)POLR1E
DMDM Disease mutations64425
Blocks (Seattle)POLR1E
SuperfamilyQ9GZS1
Human Protein Atlas [tissue]ENSG00000137054-POLR1E [tissue]
Peptide AtlasQ9GZS1
HPRD15096
IPIIPI00251989   IPI00550638   IPI00909770   IPI00909522   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZS1
IntAct (EBI)Q9GZS1
FunCoupENSG00000137054
BioGRIDPOLR1E
STRING (EMBL)POLR1E
ZODIACPOLR1E
Ontologies - Pathways
QuickGOQ9GZS1
Ontology : AmiGORNA polymerase I transcription factor binding  RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript  fibrillar center  DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  nucleolus  DNA-directed RNA polymerase I complex  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  rRNA transcription  positive regulation of gene expression, epigenetic  
Ontology : EGO-EBIRNA polymerase I transcription factor binding  RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript  fibrillar center  DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  nucleolus  DNA-directed RNA polymerase I complex  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  rRNA transcription  positive regulation of gene expression, epigenetic  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase   
NDEx NetworkPOLR1E
Atlas of Cancer Signalling NetworkPOLR1E
Wikipedia pathwaysPOLR1E
Orthology - Evolution
OrthoDB64425
GeneTree (enSembl)ENSG00000137054
Phylogenetic Trees/Animal Genes : TreeFamPOLR1E
HOVERGENQ9GZS1
HOGENOMQ9GZS1
Homologs : HomoloGenePOLR1E
Homology/Alignments : Family Browser (UCSC)POLR1E
Gene fusions - Rearrangements
Fusion: Tumor Portal POLR1E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR1E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR1E
dbVarPOLR1E
ClinVarPOLR1E
1000_GenomesPOLR1E 
Exome Variant ServerPOLR1E
ExAC (Exome Aggregation Consortium)ENSG00000137054
GNOMAD BrowserENSG00000137054
Genetic variants : HAPMAP64425
Genomic Variants (DGV)POLR1E [DGVbeta]
DECIPHERPOLR1E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR1E 
Mutations
ICGC Data PortalPOLR1E 
TCGA Data PortalPOLR1E 
Broad Tumor PortalPOLR1E
OASIS PortalPOLR1E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR1E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR1E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR1E
DgiDB (Drug Gene Interaction Database)POLR1E
DoCM (Curated mutations)POLR1E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR1E (select a term)
intoGenPOLR1E
Cancer3DPOLR1E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPOLR1E
Genetic Testing Registry POLR1E
NextProtQ9GZS1 [Medical]
TSGene64425
GENETestsPOLR1E
Target ValidationPOLR1E
Huge Navigator POLR1E [HugePedia]
snp3D : Map Gene to Disease64425
BioCentury BCIQPOLR1E
ClinGenPOLR1E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64425
Chemical/Pharm GKB GenePA142671136
Clinical trialPOLR1E
Miscellaneous
canSAR (ICR)POLR1E (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR1E
EVEXPOLR1E
GoPubMedPOLR1E
iHOPPOLR1E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:23:03 CET 2017

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