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POLR2A (RNA polymerase II subunit A)

Identity

Alias_namesPOLR2
polymerase (RNA) II (DNA directed) polypeptide A
Alias_symbol (synonym)POLRA
RPB1
Other aliasRPBh1
RPO2
RPOL2
RpIILS
hRPB220
hsRPB1
HGNC (Hugo) POLR2A
LocusID (NCBI) 5430
Atlas_Id 45769
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7484379 and ends at 7514618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AP2B1 (17q12) / POLR2A (17p13.1)CEP250 (20q11.22) / POLR2A (17p13.1)GPM6A (4q34.2) / POLR2A (17p13.1)
IKZF1 (7p12.2) / POLR2A (17p13.1)NUP188 (9q34.11) / POLR2A (17p13.1)POLR2A (17p13.1) / FBN3 (19p13.2)
POLR2A (17p13.1) / NECTIN2 (19q13.32)POLR2A (17p13.1) / POLR2A (17p13.1)POLR2A (17p13.1) / WRAP53 (17p13.1)
USP12 (13q12.13) / POLR2A (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2A   9187
Cards
Entrez_Gene (NCBI)POLR2A  5430  RNA polymerase II subunit A
AliasesPOLR2; POLRA; RPB1; RPBh1; 
RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
GeneCards (Weizmann)POLR2A
Ensembl hg19 (Hinxton)ENSG00000181222 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181222 [Gene_View]  chr17:7484379-7514618 [Contig_View]  POLR2A [Vega]
ICGC DataPortalENSG00000181222
TCGA cBioPortalPOLR2A
AceView (NCBI)POLR2A
Genatlas (Paris)POLR2A
WikiGenes5430
SOURCE (Princeton)POLR2A
Genetics Home Reference (NIH)POLR2A
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2A  -     chr17:7484379-7514618 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2A  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR2A - 17p13.1 [CytoView hg19]  POLR2A - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR2A [Mapview hg19]  POLR2A [Mapview hg38]
OMIM180660   
Gene and transcription
Genbank (Entrez)AK293777 AK304882 AW589665 BC067295 BC107140
RefSeq transcript (Entrez)NM_000937
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2A
Cluster EST : UnigeneHs.270017 [ NCBI ]
CGAP (NCI)Hs.270017
Alternative Splicing GalleryENSG00000181222
Gene ExpressionPOLR2A [ NCBI-GEO ]   POLR2A [ EBI - ARRAY_EXPRESS ]   POLR2A [ SEEK ]   POLR2A [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5430
GTEX Portal (Tissue expression)POLR2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24928   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24928  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24928
Splice isoforms : SwissVarP24928
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
PhosPhoSitePlusP24928
Domaine pattern : Prosite (Expaxy)RNA_POL_II_REPEAT (PS00115)   
Domains : Interpro (EBI)RNA_pol_asu    RNA_pol_II_repeat_euk    RNA_pol_N    RNA_pol_Rpb1_1    RNA_pol_Rpb1_3    RNA_pol_Rpb1_4    RNA_pol_Rpb1_5    RNA_pol_Rpb1_6    RNA_pol_Rpb1_7   
Domain families : Pfam (Sanger)RNA_pol_Rpb1_1 (PF04997)    RNA_pol_Rpb1_2 (PF00623)    RNA_pol_Rpb1_3 (PF04983)    RNA_pol_Rpb1_4 (PF05000)    RNA_pol_Rpb1_5 (PF04998)    RNA_pol_Rpb1_6 (PF04992)    RNA_pol_Rpb1_7 (PF04990)    RNA_pol_Rpb1_R (PF05001)   
Domain families : Pfam (NCBI)pfam04997    pfam00623    pfam04983    pfam05000    pfam04998    pfam04992    pfam04990    pfam05001   
Domain families : Smart (EMBL)RPOLA_N (SM00663)  
Conserved Domain (NCBI)POLR2A
DMDM Disease mutations5430
Blocks (Seattle)POLR2A
PDB (SRS)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)2GHQ    2GHT    2LTO    3D9K    3D9L    3D9M    3D9N    3D9O    3D9P    4JXT    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP24928
Human Protein AtlasENSG00000181222
Peptide AtlasP24928
HPRD08916
IPIIPI00334736   
Protein Interaction databases
DIP (DOE-UCLA)P24928
IntAct (EBI)P24928
FunCoupENSG00000181222
BioGRIDPOLR2A
STRING (EMBL)POLR2A
ZODIACPOLR2A
Ontologies - Pathways
QuickGOP24928
Ontology : AmiGOmRNA splicing, via spliceosome  Prp19 complex  RNA polymerase II activity  transcription, RNA-templated  DNA binding  RNA binding  DNA-directed 5'-3' RNA polymerase activity  RNA-directed 5'-3' RNA polymerase activity  protein binding  protein binding  nucleus  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  transcription-coupled nucleotide-excision repair  DNA-templated transcription, termination  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  ubiquitin protein ligase binding  positive regulation of RNA splicing  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  metal ion binding  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  Prp19 complex  RNA polymerase II activity  transcription, RNA-templated  DNA binding  RNA binding  DNA-directed 5'-3' RNA polymerase activity  RNA-directed 5'-3' RNA polymerase activity  protein binding  protein binding  nucleus  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  transcription-coupled nucleotide-excision repair  DNA-templated transcription, termination  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  ubiquitin protein ligase binding  positive regulation of RNA splicing  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  metal ion binding  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkPOLR2A
Atlas of Cancer Signalling NetworkPOLR2A
Wikipedia pathwaysPOLR2A
Orthology - Evolution
OrthoDB5430
GeneTree (enSembl)ENSG00000181222
Phylogenetic Trees/Animal Genes : TreeFamPOLR2A
HOVERGENP24928
HOGENOMP24928
Homologs : HomoloGenePOLR2A
Homology/Alignments : Family Browser (UCSC)POLR2A
Gene fusions - Rearrangements
Fusion : MitelmanPOLR2A/FBN3 [17p13.1/19p13.2]  
Fusion : MitelmanPOLR2A/WRAP53 [17p13.1/17p13.1]  [t(17;17)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2A
dbVarPOLR2A
ClinVarPOLR2A
1000_GenomesPOLR2A 
Exome Variant ServerPOLR2A
ExAC (Exome Aggregation Consortium)POLR2A (select the gene name)
Genetic variants : HAPMAP5430
Genomic Variants (DGV)POLR2A [DGVbeta]
DECIPHERPOLR2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2A 
Mutations
ICGC Data PortalPOLR2A 
TCGA Data PortalPOLR2A 
Broad Tumor PortalPOLR2A
OASIS PortalPOLR2A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPOLR2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2A
DgiDB (Drug Gene Interaction Database)POLR2A
DoCM (Curated mutations)POLR2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2A (select a term)
intoGenPOLR2A
Cancer3DPOLR2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180660   
Orphanet
MedgenPOLR2A
Genetic Testing Registry POLR2A
NextProtP24928 [Medical]
TSGene5430
GENETestsPOLR2A
Target ValidationPOLR2A
Huge Navigator POLR2A [HugePedia]
snp3D : Map Gene to Disease5430
BioCentury BCIQPOLR2A
ClinGenPOLR2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5430
Chemical/Pharm GKB GenePA33507
Clinical trialPOLR2A
Miscellaneous
canSAR (ICR)POLR2A (select the gene name)
Probes
Litterature
PubMed424 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2A
EVEXPOLR2A
GoPubMedPOLR2A
iHOPPOLR2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:16 CEST 2017

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