| Nomenclature | | HGNC | POLR2A 9187 |
| Entrez_Gene | POLR2A 5430 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
| Cards |
|---|
| GeneCards | POLR2A |
| Ensembl | POLR2A [Search_View] ENSG00000181222 [Gene_View] |
| Genatlas | POLR2A |
| GeneLynx | POLR2A |
| eGenome | POLR2A |
| euGene | 5430 |
| Genomic and cartography |
|---|
| GoldenPath | POLR2A - 17p13.1 chr17:7328574-7358655 + 17p13.1 [Description] (hg18-March_2006) |
| Ensembl | POLR2A - 17p13.1 [CytoView] |
| NCBI | Mapview |
| OMIM | Disease map [OMIM] |
| HomoloGene | POLR2A |
| Gene and transcription | | Genbank | BC067295 [ ENTREZ ] |
| Genbank | BQ891728 [ ENTREZ ] |
| Genbank | BU739765 [ ENTREZ ] |
| Genbank | CV355924 [ ENTREZ ] |
| Genbank | DA923649 [ ENTREZ ] |
| RefSeq | NM_000937 [ SRS ] NM_000937 [ ENTREZ ] |
| RefSeq | AC_000060 [ SRS ] AC_000060 [ ENTREZ ] |
| RefSeq | AC_000149 [ SRS ] AC_000149 [ ENTREZ ] |
| RefSeq | NC_000017 [ SRS ] NC_000017 [ ENTREZ ] |
| RefSeq | NT_010718 [ SRS ] NT_010718 [ ENTREZ ] |
| RefSeq | NW_001838403 [ SRS ] NW_001838403 [ ENTREZ ] |
| RefSeq | NW_926584 [ SRS ] NW_926584 [ ENTREZ ] |
| AceView | POLR2A AceView - NCBI |
| Unigene | Hs.270017 [ SRS ] Hs.270017 [ NCBI ]
HS270017 [ spliceNest ] |
| Fast-db | 3035 (alternative variants) |
| Protein : pattern, domain, 3D structure |
|---|
| SwissProt | P24928 [ SRS] P24928 [ EXPASY ] P24928 [ INTERPRO ] P24928 [ UNIPROT ] |
| Prosite | PS00115 RNA_POL_II_REPEAT [ SRS ] PS00115 RNA_POL_II_REPEAT [ Expasy ] |
| Interpro | IPR000722 RNA_pol_A [ SRS ] IPR000722 RNA_pol_A [ EBI ] |
| Interpro | IPR000684 RNA_pol_II_repeat_euk [ SRS ] IPR000684 RNA_pol_II_repeat_euk [ EBI ] |
| Interpro | IPR006592 RNA_pol_N [ SRS ] IPR006592 RNA_pol_N [ EBI ] |
| Interpro | IPR007080 RNA_pol_Rpb1_1 [ SRS ] IPR007080 RNA_pol_Rpb1_1 [ EBI ] |
| Interpro | IPR007066 RNA_pol_Rpb1_3 [ SRS ] IPR007066 RNA_pol_Rpb1_3 [ EBI ] |
| Interpro | IPR007083 RNA_pol_Rpb1_4 [ SRS ] IPR007083 RNA_pol_Rpb1_4 [ EBI ] |
| Interpro | IPR007081 RNA_pol_Rpb1_5 [ SRS ] IPR007081 RNA_pol_Rpb1_5 [ EBI ] |
| Interpro | IPR007075 RNA_pol_Rpb1_6 [ SRS ] IPR007075 RNA_pol_Rpb1_6 [ EBI ] |
| Interpro | IPR007073 RNA_pol_Rpb1_7 [ SRS ] IPR007073 RNA_pol_Rpb1_7 [ EBI ] |
| CluSTr | P24928 |
| Pfam | PF04997 RNA_pol_Rpb1_1 [ SRS ] PF04997 RNA_pol_Rpb1_1 [ Sanger ] pfam04997 [ NCBI-CDD ] |
| Pfam | PF00623 RNA_pol_Rpb1_2 [ SRS ] PF00623 RNA_pol_Rpb1_2 [ Sanger ] pfam00623 [ NCBI-CDD ] |
| Pfam | PF04983 RNA_pol_Rpb1_3 [ SRS ] PF04983 RNA_pol_Rpb1_3 [ Sanger ] pfam04983 [ NCBI-CDD ] |
| Pfam | PF05000 RNA_pol_Rpb1_4 [ SRS ] PF05000 RNA_pol_Rpb1_4 [ Sanger ] pfam05000 [ NCBI-CDD ] |
| Pfam | PF04998 RNA_pol_Rpb1_5 [ SRS ] PF04998 RNA_pol_Rpb1_5 [ Sanger ] pfam04998 [ NCBI-CDD ] |
| Pfam | PF04992 RNA_pol_Rpb1_6 [ SRS ] PF04992 RNA_pol_Rpb1_6 [ Sanger ] pfam04992 [ NCBI-CDD ] |
| Pfam | PF04990 RNA_pol_Rpb1_7 [ SRS ] PF04990 RNA_pol_Rpb1_7 [ Sanger ] pfam04990 [ NCBI-CDD ] |
| Pfam | PF05001 RNA_pol_Rpb1_R [ SRS ] PF05001 RNA_pol_Rpb1_R [ Sanger ] pfam05001 [ NCBI-CDD ] |
| Smart | SM00663 RPOLA_N [EMBL] |
| Blocks | P24928 |
| PDB | 2GHQ [ SRS ] 2GHQ [ PdbSum ], 2GHQ [ IMB ] 2GHQ [ RSDB ] |
| HPRD | 08916 |
| Protein Interaction databases |
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| DIP | P24928 |
| IntAct | P24928 |
| Polymorphism : SNP, mutations, diseases |
|---|
| OMIM | 180660 [ map ] |
| GENECLINICS | 180660 |
| SNP | POLR2A [dbSNP-NCBI] |
| SNP | NM_000937 [SNP-NCI] |
| SNP | POLR2A [GeneSNPs - Utah] POLR2A] [HGBASE - SRS] |
| HAPMAP | POLR2A [HAPMAP] |
| HGMD | POLR2A |
| General knowledge |
|---|
| Family Browser | POLR2A [UCSC Family Browser] |
| SOURCE | NM_000937 |
| SMD | Hs.270017 |
| SAGE | Hs.270017 |
| Enzyme | 2.7.7.6 [ Enzyme-Expasy ] 2.7.7.6 [ Enzyme-SRS ] 2.7.7.6 [ IntEnz-EBI ] 2.7.7.6 [ BRENDA ] 2.7.7.6 [ KEGG ] 2.7.7.6 [ WIT ] |
| GO | magnesium ion binding [Amigo] magnesium ion binding |
| GO | nuclear mRNA splicing, via spliceosome [Amigo] nuclear mRNA splicing, via spliceosome |
| GO | DNA binding [Amigo] DNA binding |
| GO | DNA binding [Amigo] DNA binding |
| GO | DNA-directed RNA polymerase activity [Amigo] DNA-directed RNA polymerase activity |
| GO | protein binding [Amigo] protein binding |
| GO | nucleus [Amigo] nucleus |
| GO | nucleoplasm [Amigo] nucleoplasm |
| GO | DNA-directed RNA polymerase II, core complex [Amigo] DNA-directed RNA polymerase II, core complex |
| GO | DNA-directed RNA polymerase II, core complex [Amigo] DNA-directed RNA polymerase II, core complex |
| GO | nucleolus [Amigo] nucleolus |
| GO | transcription [Amigo] transcription |
| GO | transcription, DNA-dependent [Amigo] transcription, DNA-dependent |
| GO | regulation of transcription, DNA-dependent [Amigo] regulation of transcription, DNA-dependent |
| GO | transcription initiation from RNA polymerase II promoter [Amigo] transcription initiation from RNA polymerase II promoter |
| GO | RNA elongation from RNA polymerase II promoter [Amigo] RNA elongation from RNA polymerase II promoter |
| GO | zinc ion binding [Amigo] zinc ion binding |
| GO | transferase activity [Amigo] transferase activity |
| GO | nucleotidyltransferase activity [Amigo] nucleotidyltransferase activity |
| BIOCARTA | CARM1 and Regulation of the Estrogen Receptor [Genes] |
| BIOCARTA | Repression of Pain Sensation by the Transcriptional Regulator DREAM [Genes] |
| BIOCARTA | Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes [Genes] |
| BIOCARTA | The information-processing pathway at the IFN-beta enhancer [Genes] |
| BIOCARTA | Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Genes] |
| BIOCARTA | Telomeres, Telomerase, Cellular Aging, and Immortality [Genes] |
| KEGG | Purine metabolism |
| KEGG | Pyrimidine metabolism |
| KEGG | RNA polymerase |
| PubGene | POLR2A |
| TreeFam | POLR2A |
| CTD | 5430 [Comparative ToxicoGenomics Database] |
| Other databases |
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| Probes |
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| Probe | POLR2A Related clones (RZPD - Berlin) |
| PubMed |
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| PubMed | 190 Pubmed reference(s) in LocusLink |
