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POLR2B (RNA polymerase II subunit B)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide B (140kD)
Alias_symbol (synonym)RPB2
Other aliasPOL2RB
hRPB140
HGNC (Hugo) POLR2B
LocusID (NCBI) 5431
Atlas_Id 51774
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 56978640 and ends at 57031162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGF2BP3 (7p15.3) / POLR2B (4q12)IGFBP7 (4q12) / POLR2B (4q12)POLR2B (4q12) / IGF2BP3 (7p15.3)
POLR2B (4q12) / RP11-631B21.2 ()POLR2B 4q12 RP11-631B21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2B   9188
Cards
Entrez_Gene (NCBI)POLR2B  5431  RNA polymerase II subunit B
AliasesPOL2RB; RPB2; hRPB140
GeneCards (Weizmann)POLR2B
Ensembl hg19 (Hinxton)ENSG00000047315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000047315 [Gene_View]  chr4:56978640-57031162 [Contig_View]  POLR2B [Vega]
ICGC DataPortalENSG00000047315
TCGA cBioPortalPOLR2B
AceView (NCBI)POLR2B
Genatlas (Paris)POLR2B
WikiGenes5431
SOURCE (Princeton)POLR2B
Genetics Home Reference (NIH)POLR2B
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2B  -     chr4:56978640-57031162 +  4q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2B  -     4q12   [Description]    (hg19-Feb_2009)
EnsemblPOLR2B - 4q12 [CytoView hg19]  POLR2B - 4q12 [CytoView hg38]
Mapping of homologs : NCBIPOLR2B [Mapview hg19]  POLR2B [Mapview hg38]
OMIM180661   
Gene and transcription
Genbank (Entrez)AF055028 AK098271 AK289823 AK294901 AK295132
RefSeq transcript (Entrez)NM_000938 NM_001303268 NM_001303269
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2B
Cluster EST : UnigeneHs.602757 [ NCBI ]
CGAP (NCI)Hs.602757
Alternative Splicing GalleryENSG00000047315
Gene ExpressionPOLR2B [ NCBI-GEO ]   POLR2B [ EBI - ARRAY_EXPRESS ]   POLR2B [ SEEK ]   POLR2B [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5431
GTEX Portal (Tissue expression)POLR2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30876   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30876  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30876
Splice isoforms : SwissVarP30876
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
PhosPhoSitePlusP30876
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNA_pol_su2_6    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_3    RNA_pol_Rpb2_4    RNA_pol_Rpb2_5    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold   
Domain families : Pfam (Sanger)RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_4 (PF04566)    RNA_pol_Rpb2_5 (PF04567)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam04563    pfam04561    pfam04565    pfam04566    pfam04567    pfam00562    pfam04560   
Conserved Domain (NCBI)POLR2B
DMDM Disease mutations5431
Blocks (Seattle)POLR2B
PDB (SRS)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP30876
Human Protein AtlasENSG00000047315
Peptide AtlasP30876
HPRD15943
IPIIPI00027808   IPI00894248   IPI00894524   IPI00894141   IPI00873948   
Protein Interaction databases
DIP (DOE-UCLA)P30876
IntAct (EBI)P30876
FunCoupENSG00000047315
BioGRIDPOLR2B
STRING (EMBL)POLR2B
ZODIACPOLR2B
Ontologies - Pathways
QuickGOP30876
Ontology : AmiGOmRNA splicing, via spliceosome  nuclear chromosome, telomeric region  RNA polymerase II activity  DNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase II, core complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  membrane  gene silencing by RNA  ribonucleoside binding  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  metal ion binding  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  nuclear chromosome, telomeric region  RNA polymerase II activity  DNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase II, core complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  membrane  gene silencing by RNA  ribonucleoside binding  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  metal ion binding  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2B
Atlas of Cancer Signalling NetworkPOLR2B
Wikipedia pathwaysPOLR2B
Orthology - Evolution
OrthoDB5431
GeneTree (enSembl)ENSG00000047315
Phylogenetic Trees/Animal Genes : TreeFamPOLR2B
HOVERGENP30876
HOGENOMP30876
Homologs : HomoloGenePOLR2B
Homology/Alignments : Family Browser (UCSC)POLR2B
Gene fusions - Rearrangements
Fusion: TCGAPOLR2B 4q12 RP11-631B21.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2B
dbVarPOLR2B
ClinVarPOLR2B
1000_GenomesPOLR2B 
Exome Variant ServerPOLR2B
ExAC (Exome Aggregation Consortium)POLR2B (select the gene name)
Genetic variants : HAPMAP5431
Genomic Variants (DGV)POLR2B [DGVbeta]
DECIPHERPOLR2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2B 
Mutations
ICGC Data PortalPOLR2B 
TCGA Data PortalPOLR2B 
Broad Tumor PortalPOLR2B
OASIS PortalPOLR2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2B
intOGen PortalPOLR2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2B
DgiDB (Drug Gene Interaction Database)POLR2B
DoCM (Curated mutations)POLR2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2B (select a term)
intoGenPOLR2B
Cancer3DPOLR2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180661   
Orphanet
MedgenPOLR2B
Genetic Testing Registry POLR2B
NextProtP30876 [Medical]
TSGene5431
GENETestsPOLR2B
Target ValidationPOLR2B
Huge Navigator POLR2B [HugePedia]
snp3D : Map Gene to Disease5431
BioCentury BCIQPOLR2B
ClinGenPOLR2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5431
Chemical/Pharm GKB GenePA33508
Clinical trialPOLR2B
Miscellaneous
canSAR (ICR)POLR2B (select the gene name)
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2B
EVEXPOLR2B
GoPubMedPOLR2B
iHOPPOLR2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:16 CEST 2017

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