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POLR2C (polymerase (RNA) II subunit C)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide C (33kD)
Alias_symbol (synonym)RPB3
Other aliasRPB31
hRPB33
hsRPB3
HGNC (Hugo) POLR2C
LocusID (NCBI) 5432
Atlas_Id 51787
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 57496551 and ends at 57505921 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2C   9189
Cards
Entrez_Gene (NCBI)POLR2C  5432  polymerase (RNA) II subunit C
AliasesRPB3; RPB31; hRPB33; hsRPB3
GeneCards (Weizmann)POLR2C
Ensembl hg19 (Hinxton)ENSG00000102978 [Gene_View]  chr16:57496551-57505921 [Contig_View]  POLR2C [Vega]
Ensembl hg38 (Hinxton)ENSG00000102978 [Gene_View]  chr16:57496551-57505921 [Contig_View]  POLR2C [Vega]
ICGC DataPortalENSG00000102978
TCGA cBioPortalPOLR2C
AceView (NCBI)POLR2C
Genatlas (Paris)POLR2C
WikiGenes5432
SOURCE (Princeton)POLR2C
Genetics Home Reference (NIH)POLR2C
Genomic and cartography
GoldenPath hg19 (UCSC)POLR2C  -     chr16:57496551-57505921 +  16q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLR2C  -     16q21   [Description]    (hg38-Dec_2013)
EnsemblPOLR2C - 16q21 [CytoView hg19]  POLR2C - 16q21 [CytoView hg38]
Mapping of homologs : NCBIPOLR2C [Mapview hg19]  POLR2C [Mapview hg38]
OMIM180663   
Gene and transcription
Genbank (Entrez)AF008443 AJ224143 AJ224144 AK293112 AK295582
RefSeq transcript (Entrez)NM_002694 NM_032940
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)POLR2C
Cluster EST : UnigeneHs.79402 [ NCBI ]
CGAP (NCI)Hs.79402
Alternative Splicing GalleryENSG00000102978
Gene ExpressionPOLR2C [ NCBI-GEO ]   POLR2C [ EBI - ARRAY_EXPRESS ]   POLR2C [ SEEK ]   POLR2C [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5432
GTEX Portal (Tissue expression)POLR2C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19387   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19387  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19387
Splice isoforms : SwissVarP19387
PhosPhoSitePlusP19387
Domaine pattern : Prosite (Expaxy)RNA_POL_D_30KD (PS00446)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_30-40kDasu_CS    DNA-dir_RNA_pol_insert    DNA-dir_RNA_pol_RpoA/D/Rpb3    RBP11-like_dimer   
Domain families : Pfam (Sanger)RNA_pol_A_bac (PF01000)    RNA_pol_L (PF01193)   
Domain families : Pfam (NCBI)pfam01000    pfam01193   
Domain families : Smart (EMBL)RPOLD (SM00662)  
Conserved Domain (NCBI)POLR2C
DMDM Disease mutations5432
Blocks (Seattle)POLR2C
SuperfamilyP19387
Human Protein AtlasENSG00000102978
Peptide AtlasP19387
HPRD15945
IPIIPI00018288   IPI00922383   
Protein Interaction databases
DIP (DOE-UCLA)P19387
IntAct (EBI)P19387
FunCoupENSG00000102978
BioGRIDPOLR2C
STRING (EMBL)POLR2C
ZODIACPOLR2C
Ontologies - Pathways
QuickGOP19387
Ontology : AmiGOmRNA splicing, via spliceosome  RNA polymerase II activity  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase II, core complex  cytoplasm  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  microtubule cytoskeleton  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA polymerase II activity  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase II, core complex  cytoplasm  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  microtubule cytoskeleton  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2C
Atlas of Cancer Signalling NetworkPOLR2C
Wikipedia pathwaysPOLR2C
Orthology - Evolution
OrthoDB5432
GeneTree (enSembl)ENSG00000102978
Phylogenetic Trees/Animal Genes : TreeFamPOLR2C
HOVERGENP19387
HOGENOMP19387
Homologs : HomoloGenePOLR2C
Homology/Alignments : Family Browser (UCSC)POLR2C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2C
dbVarPOLR2C
ClinVarPOLR2C
1000_GenomesPOLR2C 
Exome Variant ServerPOLR2C
ExAC (Exome Aggregation Consortium)POLR2C (select the gene name)
Genetic variants : HAPMAP5432
Genomic Variants (DGV)POLR2C [DGVbeta]
DECIPHER (Syndromes)16:57496551-57505921  ENSG00000102978
CONAN: Copy Number AnalysisPOLR2C 
Mutations
ICGC Data PortalPOLR2C 
TCGA Data PortalPOLR2C 
Broad Tumor PortalPOLR2C
OASIS PortalPOLR2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2C
DgiDB (Drug Gene Interaction Database)POLR2C
DoCM (Curated mutations)POLR2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2C (select a term)
intoGenPOLR2C
Cancer3DPOLR2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180663   
Orphanet
MedgenPOLR2C
Genetic Testing Registry POLR2C
NextProtP19387 [Medical]
TSGene5432
GENETestsPOLR2C
Huge Navigator POLR2C [HugePedia]
snp3D : Map Gene to Disease5432
BioCentury BCIQPOLR2C
ClinGenPOLR2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5432
Chemical/Pharm GKB GenePA33509
Clinical trialPOLR2C
Miscellaneous
canSAR (ICR)POLR2C (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2C
EVEXPOLR2C
GoPubMedPOLR2C
iHOPPOLR2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:22:10 CET 2017

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