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POLR2D (polymerase (RNA) II (DNA directed) polypeptide D)

Identity

Other namesHSRBP4
HSRPB4
RBP4
RPB16
HGNC (Hugo) POLR2D
LocusID (NCBI) 5433
Location 2q14.3
Location_base_pair Starts at 128603840 and ends at 128615729 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)POLR2D   9191
Cards
Entrez_Gene (NCBI)POLR2D  5433  polymerase (RNA) II (DNA directed) polypeptide D
GeneCards (Weizmann)POLR2D
Ensembl (Hinxton)ENSG00000144231 [Gene_View]  chr2:128603840-128615729 [Contig_View]  POLR2D [Vega]
ICGC DataPortalENSG00000144231
AceView (NCBI)POLR2D
Genatlas (Paris)POLR2D
WikiGenes5433
SOURCE (Princeton)NM_004805
Genomic and cartography
GoldenPath (UCSC)POLR2D  -  2q14.3   chr2:128603840-128615729 -  2q14.3   [Description]    (hg19-Feb_2009)
EnsemblPOLR2D - 2q14.3 [CytoView]
Mapping of homologs : NCBIPOLR2D [Mapview]
OMIM606017   
Gene and transcription
Genbank (Entrez)AA775787 BC002958 BC010427 BC017205 BC093795
RefSeq transcript (Entrez)NM_004805
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838849 NW_004929304
Consensus coding sequences : CCDS (NCBI)POLR2D
Cluster EST : UnigeneHs.715348 [ NCBI ]
CGAP (NCI)Hs.715348
Alternative Splicing : Fast-db (Paris)GSHG0017983
Alternative Splicing GalleryENSG00000144231
Gene ExpressionPOLR2D [ NCBI-GEO ]     POLR2D [ SEEK ]   POLR2D [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15514 (Uniprot)
NextProtO15514  [Medical]
With graphics : InterProO15514
Splice isoforms : SwissVarO15514 (Swissvar)
Domains : Interpro (EBI)HRDC-like    RNA_pol_II_Rpb4    RNA_pol_II_Rpb4_core   
Related proteins : CluSTrO15514
Domain families : Pfam (Sanger)RNA_pol_Rpb4 (PF03874)   
Domain families : Pfam (NCBI)pfam03874   
Domain families : Smart (EMBL)RPOL4c (SM00657)  
DMDM Disease mutations5433
Blocks (Seattle)O15514
PDB (SRS)2C35   
PDB (PDBSum)2C35   
PDB (IMB)2C35   
PDB (RSDB)2C35   
Human Protein AtlasENSG00000144231
Peptide AtlasO15514
HPRD16191
IPIIPI00007283   IPI00386677   IPI00982720   IPI00917118   IPI00915935   
Protein Interaction databases
DIP (DOE-UCLA)O15514
IntAct (EBI)O15514
FunCoupENSG00000144231
BioGRIDPOLR2D
InParanoidO15514
Interologous Interaction database O15514
IntegromeDBPOLR2D
STRING (EMBL)POLR2D
Ontologies - Pathways
Ontology : AmiGOnucleotide binding  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  mRNA splicing, via spliceosome  cytoplasmic mRNA processing body  single-stranded DNA binding  single-stranded RNA binding  DNA-directed RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  RNA splicing  gene expression  viral process  translation initiation factor binding  mRNA export from nucleus in response to heat stress  recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex  positive regulation of translational initiation  positive regulation of viral transcription  
Ontology : EGO-EBInucleotide binding  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  mRNA splicing, via spliceosome  cytoplasmic mRNA processing body  single-stranded DNA binding  single-stranded RNA binding  DNA-directed RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  RNA splicing  gene expression  viral process  translation initiation factor binding  mRNA export from nucleus in response to heat stress  recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex  positive regulation of translational initiation  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Epstein-Barr virus infection   
Protein Interaction DatabasePOLR2D
Wikipedia pathwaysPOLR2D
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)POLR2D
SNP (GeneSNP Utah)POLR2D
SNP : HGBasePOLR2D
Genetic variants : HAPMAPPOLR2D
1000_GenomesPOLR2D 
ICGC programENSG00000144231 
CONAN: Copy Number AnalysisPOLR2D 
Somatic Mutations in Cancer : COSMICPOLR2D 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDPOLR2D
OMIM606017   
MedgenPOLR2D
GENETestsPOLR2D
Disease Genetic AssociationPOLR2D
Huge Navigator POLR2D [HugePedia]  POLR2D [HugeCancerGEM]
Genomic VariantsPOLR2D  POLR2D [DGVbeta]
Exome VariantPOLR2D
dbVarPOLR2D
ClinVarPOLR2D
snp3D : Map Gene to Disease5433
General knowledge
Homologs : HomoloGenePOLR2D
Homology/Alignments : Family Browser (UCSC)POLR2D
Phylogenetic Trees/Animal Genes : TreeFamPOLR2D
Chemical/Protein Interactions : CTD5433
Chemical/Pharm GKB GenePA33511
Clinical trialPOLR2D
Cancer Resource (Charite)ENSG00000144231
Other databases
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
CoreMinePOLR2D
iHOPPOLR2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:09:19 CEST 2014

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