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POLR2F (RNA polymerase II subunit F)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide F
Alias_symbol (synonym)RPB6
HRBP14.4
Other aliasPOLRF
RPABC14.4
RPABC2
RPB14.4
RPC15
HGNC (Hugo) POLR2F
LocusID (NCBI) 5435
Atlas_Id 50235
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 37953663 and ends at 37969315 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MICALL1 (22q13.1) / POLR2F (22q13.1)PICK1 (22q13.1) / POLR2F (22q13.1)POLR2F (22q13.1) / LRFN3 (19q13.12)
POLR2F (22q13.1) / PIH1D1 (19q13.33)PICK1 22q13.1 / POLR2F 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2F   9193
Cards
Entrez_Gene (NCBI)POLR2F  5435  RNA polymerase II subunit F
AliasesHRBP14.4; POLRF; RPABC14.4; RPABC2; 
RPB14.4; RPB6; RPC15
GeneCards (Weizmann)POLR2F
Ensembl hg19 (Hinxton)ENSG00000100142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100142 [Gene_View]  chr22:37953663-37969315 [Contig_View]  POLR2F [Vega]
ICGC DataPortalENSG00000100142
TCGA cBioPortalPOLR2F
AceView (NCBI)POLR2F
Genatlas (Paris)POLR2F
WikiGenes5435
SOURCE (Princeton)POLR2F
Genetics Home Reference (NIH)POLR2F
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2F  -     chr22:37953663-37969315 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2F  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR2F - 22q13.1 [CytoView hg19]  POLR2F - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR2F [Mapview hg19]  POLR2F [Mapview hg38]
OMIM604414   
Gene and transcription
Genbank (Entrez)AK026327 AK094034 AK098727 AK311128 AK311831
RefSeq transcript (Entrez)NM_001301129 NM_001301130 NM_001301131 NM_021974
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2F
Cluster EST : UnigeneHs.735742 [ NCBI ]
CGAP (NCI)Hs.735742
Alternative Splicing GalleryENSG00000100142
Gene ExpressionPOLR2F [ NCBI-GEO ]   POLR2F [ EBI - ARRAY_EXPRESS ]   POLR2F [ SEEK ]   POLR2F [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2F [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5435
GTEX Portal (Tissue expression)POLR2F
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61218   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61218  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61218
Splice isoforms : SwissVarP61218
PhosPhoSitePlusP61218
Domaine pattern : Prosite (Expaxy)RNA_POL_K_14KD (PS01111)   
Domains : Interpro (EBI)DNA-dir_RNA_polK_14-18kDa_CS    Pol_omega/K/RPB6    RNAP_RPB6_omega    RPB6    RpoK/Rpb6   
Domain families : Pfam (Sanger)RNA_pol_Rpb6 (PF01192)   
Domain families : Pfam (NCBI)pfam01192   
Domain families : Smart (EMBL)RNA_pol_Rpb6 (SM01409)  
Conserved Domain (NCBI)POLR2F
DMDM Disease mutations5435
Blocks (Seattle)POLR2F
PDB (SRS)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)1QKL    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP61218
Human Protein AtlasENSG00000100142
Peptide AtlasP61218
HPRD05105
IPIIPI00015119   IPI00879602   IPI00880079   IPI00877920   IPI00879766   IPI00878600   
Protein Interaction databases
DIP (DOE-UCLA)P61218
IntAct (EBI)P61218
FunCoupENSG00000100142
BioGRIDPOLR2F
STRING (EMBL)POLR2F
ZODIACPOLR2F
Ontologies - Pathways
QuickGOP61218
Ontology : AmiGOmRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  fibrillar center  DNA binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  fibrillar center  DNA binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2F
Atlas of Cancer Signalling NetworkPOLR2F
Wikipedia pathwaysPOLR2F
Orthology - Evolution
OrthoDB5435
GeneTree (enSembl)ENSG00000100142
Phylogenetic Trees/Animal Genes : TreeFamPOLR2F
HOVERGENP61218
HOGENOMP61218
Homologs : HomoloGenePOLR2F
Homology/Alignments : Family Browser (UCSC)POLR2F
Gene fusions - Rearrangements
Fusion : MitelmanPICK1/POLR2F [22q13.1/22q13.1]  [t(22;22)(q13;q13)]  
Fusion: TCGAPICK1 22q13.1 POLR2F 22q13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2F [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2F
dbVarPOLR2F
ClinVarPOLR2F
1000_GenomesPOLR2F 
Exome Variant ServerPOLR2F
ExAC (Exome Aggregation Consortium)POLR2F (select the gene name)
Genetic variants : HAPMAP5435
Genomic Variants (DGV)POLR2F [DGVbeta]
DECIPHERPOLR2F [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2F 
Mutations
ICGC Data PortalPOLR2F 
TCGA Data PortalPOLR2F 
Broad Tumor PortalPOLR2F
OASIS PortalPOLR2F [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2F  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2F
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2F
DgiDB (Drug Gene Interaction Database)POLR2F
DoCM (Curated mutations)POLR2F (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2F (select a term)
intoGenPOLR2F
Cancer3DPOLR2F(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604414   
Orphanet
MedgenPOLR2F
Genetic Testing Registry POLR2F
NextProtP61218 [Medical]
TSGene5435
GENETestsPOLR2F
Huge Navigator POLR2F [HugePedia]
snp3D : Map Gene to Disease5435
BioCentury BCIQPOLR2F
ClinGenPOLR2F
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5435
Chemical/Pharm GKB GenePA33513
Clinical trialPOLR2F
Miscellaneous
canSAR (ICR)POLR2F (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2F
EVEXPOLR2F
GoPubMedPOLR2F
iHOPPOLR2F
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:01 CEST 2017

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