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POLR2H (RNA polymerase II subunit H)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide H
Alias_symbol (synonym)RPB8
Other aliasRPABC3
RPB17
HGNC (Hugo) POLR2H
LocusID (NCBI) 5437
Atlas_Id 51799
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184362983 and ends at 184368595 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
POLR2H (3q27.1) / DTX3L (3q21.1)POLR2H (3q27.1) / SRRT (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2H   9195
Cards
Entrez_Gene (NCBI)POLR2H  5437  RNA polymerase II subunit H
AliasesRPABC3; RPB17; RPB8
GeneCards (Weizmann)POLR2H
Ensembl hg19 (Hinxton)ENSG00000163882 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163882 [Gene_View]  chr3:184362983-184368595 [Contig_View]  POLR2H [Vega]
ICGC DataPortalENSG00000163882
TCGA cBioPortalPOLR2H
AceView (NCBI)POLR2H
Genatlas (Paris)POLR2H
WikiGenes5437
SOURCE (Princeton)POLR2H
Genetics Home Reference (NIH)POLR2H
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2H  -     chr3:184362983-184368595 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2H  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR2H - 3q27.1 [CytoView hg19]  POLR2H - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR2H [Mapview hg19]  POLR2H [Mapview hg38]
OMIM606023   
Gene and transcription
Genbank (Entrez)AA431357 AI244238 BC000739 BG529732 BI603667
RefSeq transcript (Entrez)NM_001278698 NM_001278699 NM_001278700 NM_001278714 NM_001278715 NM_001346879 NM_006232
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2H
Cluster EST : UnigeneHs.432574 [ NCBI ]
CGAP (NCI)Hs.432574
Alternative Splicing GalleryENSG00000163882
Gene ExpressionPOLR2H [ NCBI-GEO ]   POLR2H [ EBI - ARRAY_EXPRESS ]   POLR2H [ SEEK ]   POLR2H [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5437
GTEX Portal (Tissue expression)POLR2H
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52434   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52434  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52434
Splice isoforms : SwissVarP52434
PhosPhoSitePlusP52434
Domains : Interpro (EBI)NA-bd_OB-fold    RNA_pol_Rpb8   
Domain families : Pfam (Sanger)RNA_pol_Rpb8 (PF03870)   
Domain families : Pfam (NCBI)pfam03870   
Domain families : Smart (EMBL)RPOL8c (SM00658)  
Conserved Domain (NCBI)POLR2H
DMDM Disease mutations5437
Blocks (Seattle)POLR2H
PDB (SRS)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)2F3I    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP52434
Human Protein AtlasENSG00000163882
Peptide AtlasP52434
HPRD09082
IPIIPI00003309   IPI00924792   IPI00924545   IPI00927876   IPI00927637   IPI00791019   IPI00927044   
Protein Interaction databases
DIP (DOE-UCLA)P52434
IntAct (EBI)P52434
FunCoupENSG00000163882
BioGRIDPOLR2H
STRING (EMBL)POLR2H
ZODIACPOLR2H
Ontologies - Pathways
QuickGOP52434
Ontology : AmiGOmRNA splicing, via spliceosome  single-stranded DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  cytosol  transcription-coupled nucleotide-excision repair  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  protein-DNA complex  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  single-stranded DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  cytosol  transcription-coupled nucleotide-excision repair  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  protein-DNA complex  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2H
Atlas of Cancer Signalling NetworkPOLR2H
Wikipedia pathwaysPOLR2H
Orthology - Evolution
OrthoDB5437
GeneTree (enSembl)ENSG00000163882
Phylogenetic Trees/Animal Genes : TreeFamPOLR2H
HOVERGENP52434
HOGENOMP52434
Homologs : HomoloGenePOLR2H
Homology/Alignments : Family Browser (UCSC)POLR2H
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2H
dbVarPOLR2H
ClinVarPOLR2H
1000_GenomesPOLR2H 
Exome Variant ServerPOLR2H
ExAC (Exome Aggregation Consortium)POLR2H (select the gene name)
Genetic variants : HAPMAP5437
Genomic Variants (DGV)POLR2H [DGVbeta]
DECIPHERPOLR2H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2H 
Mutations
ICGC Data PortalPOLR2H 
TCGA Data PortalPOLR2H 
Broad Tumor PortalPOLR2H
OASIS PortalPOLR2H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2H
DgiDB (Drug Gene Interaction Database)POLR2H
DoCM (Curated mutations)POLR2H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2H (select a term)
intoGenPOLR2H
Cancer3DPOLR2H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606023   
Orphanet
MedgenPOLR2H
Genetic Testing Registry POLR2H
NextProtP52434 [Medical]
TSGene5437
GENETestsPOLR2H
Target ValidationPOLR2H
Huge Navigator POLR2H [HugePedia]
snp3D : Map Gene to Disease5437
BioCentury BCIQPOLR2H
ClinGenPOLR2H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5437
Chemical/Pharm GKB GenePA33515
Clinical trialPOLR2H
Miscellaneous
canSAR (ICR)POLR2H (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2H
EVEXPOLR2H
GoPubMedPOLR2H
iHOPPOLR2H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:11:10 CEST 2017

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