Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

POLR2I (RNA polymerase II subunit I)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide I (14.5kD)
Alias_symbol (synonym)RPB9
hRPB14.5
Other alias
HGNC (Hugo) POLR2I
LocusID (NCBI) 5438
Atlas_Id 51795
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 36113709 and ends at 36115304 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
POLR2I (19q13.12) / DBI (2q14.2)POLR2I (19q13.12) / LAMP2 (Xq24)ZC3H4 (19q13.32) / POLR2I (19q13.12)
ZC3H4 19q13.32 / POLR2I 19q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2I   9196
Cards
Entrez_Gene (NCBI)POLR2I  5438  RNA polymerase II subunit I
AliasesRPB9; hRPB14.5
GeneCards (Weizmann)POLR2I
Ensembl hg19 (Hinxton)ENSG00000105258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105258 [Gene_View]  chr19:36113709-36115304 [Contig_View]  POLR2I [Vega]
ICGC DataPortalENSG00000105258
TCGA cBioPortalPOLR2I
AceView (NCBI)POLR2I
Genatlas (Paris)POLR2I
WikiGenes5438
SOURCE (Princeton)POLR2I
Genetics Home Reference (NIH)POLR2I
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2I  -     chr19:36113709-36115304 -  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2I  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblPOLR2I - 19q13.12 [CytoView hg19]  POLR2I - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIPOLR2I [Mapview hg19]  POLR2I [Mapview hg38]
OMIM180662   
Gene and transcription
Genbank (Entrez)AK312206 BC017112 BC017860 BC067794 DQ893214
RefSeq transcript (Entrez)NM_006233
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2I
Cluster EST : UnigeneHs.47062 [ NCBI ]
CGAP (NCI)Hs.47062
Alternative Splicing GalleryENSG00000105258
Gene ExpressionPOLR2I [ NCBI-GEO ]   POLR2I [ EBI - ARRAY_EXPRESS ]   POLR2I [ SEEK ]   POLR2I [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2I [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5438
GTEX Portal (Tissue expression)POLR2I
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36954   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36954  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36954
Splice isoforms : SwissVarP36954
PhosPhoSitePlusP36954
Domaine pattern : Prosite (Expaxy)RNA_POL_M_15KD (PS01030)    ZF_TFIIS_1 (PS00466)    ZF_TFIIS_2 (PS51133)   
Domains : Interpro (EBI)DNA-dir_RNA_pol-M_15_CS    DNA-dir_RNA_pol_M/15kDasu    Rpa12/Rpb9/Rpc10/TFS    Zn_ribbon_RPB9_C    Znf_TFIIS   
Domain families : Pfam (Sanger)RNA_POL_M_15KD (PF02150)    TFIIS_C (PF01096)   
Domain families : Pfam (NCBI)pfam02150    pfam01096   
Domain families : Smart (EMBL)RPOL9 (SM00661)  ZnF_C2C2 (SM00440)  
Conserved Domain (NCBI)POLR2I
DMDM Disease mutations5438
Blocks (Seattle)POLR2I
PDB (SRS)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP36954
Human Protein AtlasENSG00000105258
Peptide AtlasP36954
HPRD15944
IPIIPI00006113   
Protein Interaction databases
DIP (DOE-UCLA)P36954
IntAct (EBI)P36954
FunCoupENSG00000105258
BioGRIDPOLR2I
STRING (EMBL)POLR2I
ZODIACPOLR2I
Ontologies - Pathways
QuickGOP36954
Ontology : AmiGOmRNA splicing, via spliceosome  nucleic acid binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  mRNA cleavage  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  nucleic acid binding  DNA-directed 5'-3' RNA polymerase activity  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  nucleolus  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  mRNA cleavage  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2I
Atlas of Cancer Signalling NetworkPOLR2I
Wikipedia pathwaysPOLR2I
Orthology - Evolution
OrthoDB5438
GeneTree (enSembl)ENSG00000105258
Phylogenetic Trees/Animal Genes : TreeFamPOLR2I
HOVERGENP36954
HOGENOMP36954
Homologs : HomoloGenePOLR2I
Homology/Alignments : Family Browser (UCSC)POLR2I
Gene fusions - Rearrangements
Fusion : MitelmanZC3H4/POLR2I [19q13.32/19q13.12]  [t(19;19)(q13;q13)]  
Fusion: TCGAZC3H4 19q13.32 POLR2I 19q13.12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2I [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2I
dbVarPOLR2I
ClinVarPOLR2I
1000_GenomesPOLR2I 
Exome Variant ServerPOLR2I
ExAC (Exome Aggregation Consortium)POLR2I (select the gene name)
Genetic variants : HAPMAP5438
Genomic Variants (DGV)POLR2I [DGVbeta]
DECIPHERPOLR2I [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2I 
Mutations
ICGC Data PortalPOLR2I 
TCGA Data PortalPOLR2I 
Broad Tumor PortalPOLR2I
OASIS PortalPOLR2I [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2I  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2I
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2I
DgiDB (Drug Gene Interaction Database)POLR2I
DoCM (Curated mutations)POLR2I (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2I (select a term)
intoGenPOLR2I
Cancer3DPOLR2I(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180662   
Orphanet
MedgenPOLR2I
Genetic Testing Registry POLR2I
NextProtP36954 [Medical]
TSGene5438
GENETestsPOLR2I
Target ValidationPOLR2I
Huge Navigator POLR2I [HugePedia]
snp3D : Map Gene to Disease5438
BioCentury BCIQPOLR2I
ClinGenPOLR2I
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5438
Chemical/Pharm GKB GenePA33516
Clinical trialPOLR2I
Miscellaneous
canSAR (ICR)POLR2I (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2I
EVEXPOLR2I
GoPubMedPOLR2I
iHOPPOLR2I
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:50:18 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.