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POLR2J (RNA polymerase II subunit J)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide J (13.3kD)
Alias_symbol (synonym)RPB11
hRPB14
RPB11A
RPB11m
POLR2J1
Other alias
HGNC (Hugo) POLR2J
LocusID (NCBI) 5439
Atlas_Id 51777
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102473101 and ends at 102478934 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLR2J (7q22.1) / DLGAP4 (20q11.23)POLR2J (7q22.1) / STARD13 (13q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2J   9197
Cards
Entrez_Gene (NCBI)POLR2J  5439  RNA polymerase II subunit J
AliasesPOLR2J1; RPB11; RPB11A; RPB11m; 
hRPB14
GeneCards (Weizmann)POLR2J
Ensembl hg19 (Hinxton)ENSG00000005075 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005075 [Gene_View]  chr7:102473101-102478934 [Contig_View]  POLR2J [Vega]
ICGC DataPortalENSG00000005075
TCGA cBioPortalPOLR2J
AceView (NCBI)POLR2J
Genatlas (Paris)POLR2J
WikiGenes5439
SOURCE (Princeton)POLR2J
Genetics Home Reference (NIH)POLR2J
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2J  -     chr7:102473101-102478934 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2J  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR2J - 7q22.1 [CytoView hg19]  POLR2J - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR2J [Mapview hg19]  POLR2J [Mapview hg38]
OMIM604150   
Gene and transcription
Genbank (Entrez)AK290515 BC024165 BC040116 BC065711 BC139902
RefSeq transcript (Entrez)NM_006234
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2J
Cluster EST : UnigeneHs.654952 [ NCBI ]
CGAP (NCI)Hs.654952
Alternative Splicing GalleryENSG00000005075
Gene ExpressionPOLR2J [ NCBI-GEO ]   POLR2J [ EBI - ARRAY_EXPRESS ]   POLR2J [ SEEK ]   POLR2J [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2J [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5439
GTEX Portal (Tissue expression)POLR2J
Human Protein AtlasENSG00000005075-POLR2J [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52435   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52435  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52435
Splice isoforms : SwissVarP52435
PhosPhoSitePlusP52435
Domaine pattern : Prosite (Expaxy)RNA_POL_L_13KD (PS01154)   
Domains : Interpro (EBI)RBP11-like_dimer    RNA_pol_Rpb11_13-16kDa_CS   
Domain families : Pfam (Sanger)RNA_pol_L_2 (PF13656)   
Domain families : Pfam (NCBI)pfam13656   
Conserved Domain (NCBI)POLR2J
DMDM Disease mutations5439
Blocks (Seattle)POLR2J
PDB (SRS)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP52435
Human Protein Atlas [tissue]ENSG00000005075-POLR2J [tissue]
Peptide AtlasP52435
HPRD16038
IPIIPI00939577   IPI00003310   
Protein Interaction databases
DIP (DOE-UCLA)P52435
IntAct (EBI)P52435
FunCoupENSG00000005075
BioGRIDPOLR2J
STRING (EMBL)POLR2J
ZODIACPOLR2J
Ontologies - Pathways
QuickGOP52435
Ontology : AmiGOmRNA splicing, via spliceosome  RNA polymerase II activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  LRR domain binding  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA polymerase II activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  LRR domain binding  gene silencing by RNA  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2J
Atlas of Cancer Signalling NetworkPOLR2J
Wikipedia pathwaysPOLR2J
Orthology - Evolution
OrthoDB5439
GeneTree (enSembl)ENSG00000005075
Phylogenetic Trees/Animal Genes : TreeFamPOLR2J
HOVERGENP52435
HOGENOMP52435
Homologs : HomoloGenePOLR2J
Homology/Alignments : Family Browser (UCSC)POLR2J
Gene fusions - Rearrangements
Tumor Fusion PortalPOLR2J
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2J [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2J
dbVarPOLR2J
ClinVarPOLR2J
1000_GenomesPOLR2J 
Exome Variant ServerPOLR2J
ExAC (Exome Aggregation Consortium)ENSG00000005075
GNOMAD BrowserENSG00000005075
Genetic variants : HAPMAP5439
Genomic Variants (DGV)POLR2J [DGVbeta]
DECIPHERPOLR2J [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2J 
Mutations
ICGC Data PortalPOLR2J 
TCGA Data PortalPOLR2J 
Broad Tumor PortalPOLR2J
OASIS PortalPOLR2J [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2J  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2J
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2J
DgiDB (Drug Gene Interaction Database)POLR2J
DoCM (Curated mutations)POLR2J (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2J (select a term)
intoGenPOLR2J
Cancer3DPOLR2J(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604150   
Orphanet
DisGeNETPOLR2J
MedgenPOLR2J
Genetic Testing Registry POLR2J
NextProtP52435 [Medical]
TSGene5439
GENETestsPOLR2J
Target ValidationPOLR2J
Huge Navigator POLR2J [HugePedia]
snp3D : Map Gene to Disease5439
BioCentury BCIQPOLR2J
ClinGenPOLR2J
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5439
Chemical/Pharm GKB GenePA33517
Clinical trialPOLR2J
Miscellaneous
canSAR (ICR)POLR2J (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2J
EVEXPOLR2J
GoPubMedPOLR2J
iHOPPOLR2J
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:34 CET 2017

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