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POLR2K (polymerase (RNA) II subunit K)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide K
Alias_symbol (synonym)RPB10alpha
Other aliasABC10-alpha
RPABC4
RPB12
RPB7.0
hRPB7.0
hsRPB10a
HGNC (Hugo) POLR2K
LocusID (NCBI) 5440
Atlas_Id 51784
Location 8q22.2  [Link to chromosome band 8q22]
Location_base_pair Starts at 101162839 and ends at 101166230 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
STK3 (8q22.2) / POLR2K (8q22.2)STK3 8q22.2 / POLR2K 8q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2K   9198
Cards
Entrez_Gene (NCBI)POLR2K  5440  polymerase (RNA) II subunit K
AliasesABC10-alpha; RPABC4; RPB10alpha; RPB12; 
RPB7.0; hRPB7.0; hsRPB10a
GeneCards (Weizmann)POLR2K
Ensembl hg19 (Hinxton)ENSG00000147669 [Gene_View]  chr8:101162839-101166230 [Contig_View]  POLR2K [Vega]
Ensembl hg38 (Hinxton)ENSG00000147669 [Gene_View]  chr8:101162839-101166230 [Contig_View]  POLR2K [Vega]
ICGC DataPortalENSG00000147669
TCGA cBioPortalPOLR2K
AceView (NCBI)POLR2K
Genatlas (Paris)POLR2K
WikiGenes5440
SOURCE (Princeton)POLR2K
Genetics Home Reference (NIH)POLR2K
Genomic and cartography
GoldenPath hg19 (UCSC)POLR2K  -     chr8:101162839-101166230 +  8q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLR2K  -     8q22.2   [Description]    (hg38-Dec_2013)
EnsemblPOLR2K - 8q22.2 [CytoView hg19]  POLR2K - 8q22.2 [CytoView hg38]
Mapping of homologs : NCBIPOLR2K [Mapview hg19]  POLR2K [Mapview hg38]
OMIM606033   
Gene and transcription
Genbank (Entrez)BC000806 BC018157 CR456870 DQ891159 DQ894340
RefSeq transcript (Entrez)NM_005034
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_033832 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)POLR2K
Cluster EST : UnigeneHs.351475 [ NCBI ]
CGAP (NCI)Hs.351475
Alternative Splicing GalleryENSG00000147669
Gene ExpressionPOLR2K [ NCBI-GEO ]   POLR2K [ EBI - ARRAY_EXPRESS ]   POLR2K [ SEEK ]   POLR2K [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5440
GTEX Portal (Tissue expression)POLR2K
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53803   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53803  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53803
Splice isoforms : SwissVarP53803
PhosPhoSitePlusP53803
Domains : Interpro (EBI)RNAP_P/RPABC4    RPABC4/Spt4   
Domain families : Pfam (Sanger)DNA_RNApol_7kD (PF03604)   
Domain families : Pfam (NCBI)pfam03604   
Domain families : Smart (EMBL)RPOLCX (SM00659)  
Conserved Domain (NCBI)POLR2K
DMDM Disease mutations5440
Blocks (Seattle)POLR2K
SuperfamilyP53803
Human Protein AtlasENSG00000147669
Peptide AtlasP53803
HPRD05826
IPIIPI00023975   IPI00974493   
Protein Interaction databases
DIP (DOE-UCLA)P53803
IntAct (EBI)P53803
FunCoupENSG00000147669
BioGRIDPOLR2K
STRING (EMBL)POLR2K
ZODIACPOLR2K
Ontologies - Pathways
QuickGOP53803
Ontology : AmiGOmRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  DNA binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  DNA binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2K
Atlas of Cancer Signalling NetworkPOLR2K
Wikipedia pathwaysPOLR2K
Orthology - Evolution
OrthoDB5440
GeneTree (enSembl)ENSG00000147669
Phylogenetic Trees/Animal Genes : TreeFamPOLR2K
HOVERGENP53803
HOGENOMP53803
Homologs : HomoloGenePOLR2K
Homology/Alignments : Family Browser (UCSC)POLR2K
Gene fusions - Rearrangements
Fusion : MitelmanSTK3/POLR2K [8q22.2/8q22.2]  [t(8;8)(q22;q22)]  
Fusion: TCGASTK3 8q22.2 POLR2K 8q22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2K
dbVarPOLR2K
ClinVarPOLR2K
1000_GenomesPOLR2K 
Exome Variant ServerPOLR2K
ExAC (Exome Aggregation Consortium)POLR2K (select the gene name)
Genetic variants : HAPMAP5440
Genomic Variants (DGV)POLR2K [DGVbeta]
DECIPHER (Syndromes)8:101162839-101166230  ENSG00000147669
CONAN: Copy Number AnalysisPOLR2K 
Mutations
ICGC Data PortalPOLR2K 
TCGA Data PortalPOLR2K 
Broad Tumor PortalPOLR2K
OASIS PortalPOLR2K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2K
DgiDB (Drug Gene Interaction Database)POLR2K
DoCM (Curated mutations)POLR2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2K (select a term)
intoGenPOLR2K
Cancer3DPOLR2K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606033   
Orphanet
MedgenPOLR2K
Genetic Testing Registry POLR2K
NextProtP53803 [Medical]
TSGene5440
GENETestsPOLR2K
Huge Navigator POLR2K [HugePedia]
snp3D : Map Gene to Disease5440
BioCentury BCIQPOLR2K
ClinGenPOLR2K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5440
Chemical/Pharm GKB GenePA33518
Clinical trialPOLR2K
Miscellaneous
canSAR (ICR)POLR2K (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2K
EVEXPOLR2K
GoPubMedPOLR2K
iHOPPOLR2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:22:12 CET 2017

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