Atlas of Genetics and Cytogenetics in Oncology and Haematology


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POLR2L (RNA polymerase II subunit L)

Identity

Alias_namespolymerase (RNA) II (DNA directed) polypeptide L
Alias_symbol (synonym)RPB10beta
RBP10
RPABC5
RPB7.6
hRPB7.6
hsRPB10b
Other aliasRPB10
HGNC (Hugo) POLR2L
LocusID (NCBI) 5441
Atlas_Id 51780
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 839721 and ends at 842529 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR2L   9199
Cards
Entrez_Gene (NCBI)POLR2L  5441  RNA polymerase II subunit L
AliasesRBP10; RPABC5; RPB10; RPB10beta; 
RPB7.6; hRPB7.6
GeneCards (Weizmann)POLR2L
Ensembl hg19 (Hinxton)ENSG00000177700 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177700 [Gene_View]  chr11:839721-842529 [Contig_View]  POLR2L [Vega]
ICGC DataPortalENSG00000177700
TCGA cBioPortalPOLR2L
AceView (NCBI)POLR2L
Genatlas (Paris)POLR2L
WikiGenes5441
SOURCE (Princeton)POLR2L
Genetics Home Reference (NIH)POLR2L
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2L  -     chr11:839721-842529 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2L  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblPOLR2L - 11p15.5 [CytoView hg19]  POLR2L - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIPOLR2L [Mapview hg19]  POLR2L [Mapview hg38]
OMIM601189   
Gene and transcription
Genbank (Entrez)AJ420546 AK311997 BC005903 BC018649 BQ435190
RefSeq transcript (Entrez)NM_021128
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2L
Cluster EST : UnigeneHs.441072 [ NCBI ]
CGAP (NCI)Hs.441072
Alternative Splicing GalleryENSG00000177700
Gene ExpressionPOLR2L [ NCBI-GEO ]   POLR2L [ EBI - ARRAY_EXPRESS ]   POLR2L [ SEEK ]   POLR2L [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5441
GTEX Portal (Tissue expression)POLR2L
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62875   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62875  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62875
Splice isoforms : SwissVarP62875
PhosPhoSitePlusP62875
Domaine pattern : Prosite (Expaxy)RNA_POL_N_8KD (PS01112)   
Domains : Interpro (EBI)Homeobox-like    RNA_pol_su_RPB10    RNA_pol_suN_Zn-BS    RNAP_N/Rpb10   
Domain families : Pfam (Sanger)RNA_pol_N (PF01194)   
Domain families : Pfam (NCBI)pfam01194   
Domain structure : Prodom (Prabi Lyon)RNA_pol_N/8_sub (PD006539)   
Conserved Domain (NCBI)POLR2L
DMDM Disease mutations5441
Blocks (Seattle)POLR2L
PDB (SRS)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP62875
Human Protein AtlasENSG00000177700
Peptide AtlasP62875
HPRD01155
IPIIPI00003311   
Protein Interaction databases
DIP (DOE-UCLA)P62875
IntAct (EBI)P62875
FunCoupENSG00000177700
BioGRIDPOLR2L
STRING (EMBL)POLR2L
ZODIACPOLR2L
Ontologies - Pathways
QuickGOP62875
Ontology : AmiGOmRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA polymerase I activity  RNA polymerase II activity  RNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleus  nucleoplasm  DNA-directed RNA polymerase II, core complex  DNA-directed RNA polymerase III complex  DNA-directed RNA polymerase I complex  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription from RNA polymerase III promoter  zinc ion binding  fibroblast growth factor receptor signaling pathway  gene expression  gene silencing by RNA  positive regulation of type I interferon production  somatic stem cell population maintenance  snRNA transcription from RNA polymerase II promoter  positive regulation of gene expression, epigenetic  positive regulation of viral transcription  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Huntington's disease    Epstein-Barr virus infection   
NDEx NetworkPOLR2L
Atlas of Cancer Signalling NetworkPOLR2L
Wikipedia pathwaysPOLR2L
Orthology - Evolution
OrthoDB5441
GeneTree (enSembl)ENSG00000177700
Phylogenetic Trees/Animal Genes : TreeFamPOLR2L
HOVERGENP62875
HOGENOMP62875
Homologs : HomoloGenePOLR2L
Homology/Alignments : Family Browser (UCSC)POLR2L
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR2L
dbVarPOLR2L
ClinVarPOLR2L
1000_GenomesPOLR2L 
Exome Variant ServerPOLR2L
ExAC (Exome Aggregation Consortium)POLR2L (select the gene name)
Genetic variants : HAPMAP5441
Genomic Variants (DGV)POLR2L [DGVbeta]
DECIPHERPOLR2L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2L 
Mutations
ICGC Data PortalPOLR2L 
TCGA Data PortalPOLR2L 
Broad Tumor PortalPOLR2L
OASIS PortalPOLR2L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR2L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR2L
DgiDB (Drug Gene Interaction Database)POLR2L
DoCM (Curated mutations)POLR2L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2L (select a term)
intoGenPOLR2L
Cancer3DPOLR2L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601189   
Orphanet
MedgenPOLR2L
Genetic Testing Registry POLR2L
NextProtP62875 [Medical]
TSGene5441
GENETestsPOLR2L
Target ValidationPOLR2L
Huge Navigator POLR2L [HugePedia]
snp3D : Map Gene to Disease5441
BioCentury BCIQPOLR2L
ClinGenPOLR2L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5441
Chemical/Pharm GKB GenePA33519
Clinical trialPOLR2L
Miscellaneous
canSAR (ICR)POLR2L (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2L
EVEXPOLR2L
GoPubMedPOLR2L
iHOPPOLR2L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:19 CEST 2017

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