| Nomenclature |
|---|
| HGNC (Hugo) | POLR2L 9199 |
| Cards |
|---|
| Entrez_Gene (NCBI) | POLR2L 5441 RNA polymerase II subunit L |
| Aliases | RBP10; RPABC5; RPB10; RPB10beta; |
| RPB7.6; hRPB7.6 |
| GeneCards (Weizmann) | POLR2L |
| Ensembl hg19 (Hinxton) | ENSG00000177700 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000177700 [Gene_View] chr11:839721-842529 [Contig_View] POLR2L [Vega] |
| ICGC DataPortal | ENSG00000177700 |
| TCGA cBioPortal | POLR2L |
| AceView (NCBI) | POLR2L |
| Genatlas (Paris) | POLR2L |
| WikiGenes | 5441 |
| SOURCE (Princeton) | POLR2L |
| Genetics Home Reference (NIH) | POLR2L |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | POLR2L - chr11:839721-842529 - 11p15.5 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | POLR2L - 11p15.5 [Description] (hg19-Feb_2009) |
| Ensembl | POLR2L - 11p15.5 [CytoView hg19] POLR2L - 11p15.5 [CytoView hg38] |
| Mapping of homologs : NCBI | POLR2L [Mapview hg19] POLR2L [Mapview hg38] |
| OMIM | 601189 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AJ420546 AK311997 BC005903 BC018649 BQ435190 |
| RefSeq transcript (Entrez) | NM_021128 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | POLR2L |
| Cluster EST : Unigene | Hs.441072 [ NCBI ] |
| CGAP (NCI) | Hs.441072 |
| Alternative Splicing Gallery | ENSG00000177700 |
| Gene Expression | POLR2L [ NCBI-GEO ] POLR2L [ EBI - ARRAY_EXPRESS ]
POLR2L [ SEEK ] POLR2L [ MEM ] |
| Gene Expression Viewer (FireBrowse) | POLR2L [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5441 |
| GTEX Portal (Tissue expression) | POLR2L |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P62875 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P62875 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P62875 |
| Splice isoforms : SwissVar | P62875 |
| PhosPhoSitePlus | P62875 |
| Domaine pattern : Prosite (Expaxy) | RNA_POL_N_8KD (PS01112) |
| Domains : Interpro (EBI) | Homeobox-like RNA_pol_su_RPB10 RNA_pol_suN_Zn-BS RNAP_N/Rpb10 |
| Domain families : Pfam (Sanger) | RNA_pol_N (PF01194) |
| Domain families : Pfam (NCBI) | pfam01194 |
| Domain structure : Prodom (Prabi Lyon) | RNA_pol_N/8_sub (PD006539) |
| Conserved Domain (NCBI) | POLR2L |
| DMDM Disease mutations | 5441 |
| Blocks (Seattle) | POLR2L |
| PDB (SRS) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| PDB (PDBSum) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| PDB (IMB) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| PDB (RSDB) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| Structural Biology KnowledgeBase | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| SCOP (Structural Classification of Proteins) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| CATH (Classification of proteins structures) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD |
| Superfamily | P62875 |
| Human Protein Atlas | ENSG00000177700 |
| Peptide Atlas | P62875 |
| HPRD | 01155 |
| IPI | IPI00003311 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P62875 |
| IntAct (EBI) | P62875 |
| FunCoup | ENSG00000177700 |
| BioGRID | POLR2L |
| STRING (EMBL) | POLR2L |
| ZODIAC | POLR2L |
| Ontologies - Pathways |
|---|
| QuickGO | P62875 |
| Ontology : AmiGO | mRNA splicing, via spliceosome RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex cytosol transcription-coupled nucleotide-excision repair regulation of transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription from RNA polymerase III promoter zinc ion binding fibroblast growth factor receptor signaling pathway gene expression gene silencing by RNA positive regulation of type I interferon production somatic stem cell population maintenance snRNA transcription from RNA polymerase II promoter positive regulation of gene expression, epigenetic positive regulation of viral transcription |
| Ontology : EGO-EBI | mRNA splicing, via spliceosome RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm DNA-directed RNA polymerase II, core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex cytosol transcription-coupled nucleotide-excision repair regulation of transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription from RNA polymerase III promoter zinc ion binding fibroblast growth factor receptor signaling pathway gene expression gene silencing by RNA positive regulation of type I interferon production somatic stem cell population maintenance snRNA transcription from RNA polymerase II promoter positive regulation of gene expression, epigenetic positive regulation of viral transcription |
| Pathways : KEGG | Purine metabolism Pyrimidine metabolism RNA polymerase Cytosolic DNA-sensing pathway Huntington's disease Epstein-Barr virus infection |
| NDEx Network | POLR2L |
| Atlas of Cancer Signalling Network | POLR2L |
| Wikipedia pathways | POLR2L |
| Orthology - Evolution |
|---|
| OrthoDB | 5441 |
| GeneTree (enSembl) | ENSG00000177700 |
| Phylogenetic Trees/Animal Genes : TreeFam | POLR2L |
| HOVERGEN | P62875 |
| HOGENOM | P62875 |
| Homologs : HomoloGene | POLR2L |
| Homology/Alignments : Family Browser (UCSC) | POLR2L |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | POLR2L [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | POLR2L |
| dbVar | POLR2L |
| ClinVar | POLR2L |
| 1000_Genomes | POLR2L |
| Exome Variant Server | POLR2L |
| ExAC (Exome Aggregation Consortium) | POLR2L (select the gene name) |
| Genetic variants : HAPMAP | 5441 |
| Genomic Variants (DGV) | POLR2L [DGVbeta] |
| DECIPHER | POLR2L [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | POLR2L |
| Mutations |
|---|
| ICGC Data Portal | POLR2L |
| TCGA Data Portal | POLR2L |
| Broad Tumor Portal | POLR2L |
| OASIS Portal | POLR2L [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | POLR2L [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | POLR2L |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search POLR2L |
| DgiDB (Drug Gene Interaction Database) | POLR2L |
| DoCM (Curated mutations) | POLR2L (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | POLR2L (select a term) |
| intoGen | POLR2L |
| Cancer3D | POLR2L(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601189 |
| Orphanet | |
| Medgen | POLR2L |
| Genetic Testing Registry | POLR2L
|
| NextProt | P62875 [Medical] |
| TSGene | 5441 |
| GENETests | POLR2L |
| Target Validation | POLR2L |
| Huge Navigator |
POLR2L [HugePedia] |
| snp3D : Map Gene to Disease | 5441 |
| BioCentury BCIQ | POLR2L |
| ClinGen | POLR2L |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5441 |
| Chemical/Pharm GKB Gene | PA33519 |
| Clinical trial | POLR2L |
| Miscellaneous |
|---|
| canSAR (ICR) | POLR2L (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 115 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | POLR2L |
| EVEX | POLR2L |
| GoPubMed | POLR2L |
| iHOP | POLR2L |
