| Nomenclature |
|---|
| HGNC (Hugo) | POLR2L 9199 |
| Cards |
|---|
| Entrez_Gene (NCBI) | POLR2L RNA polymerase II, I and III subunit L |
| Aliases | RBP10; RPABC5; RPB10; RPB10beta; |
| RPB7.6; hRPB7.6 |
| GeneCards (Weizmann) | POLR2L |
| Ensembl hg19 (Hinxton) | ENSG00000177700 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000177700 [Gene_View] ENSG00000177700 [Sequence] chr11:839721-842529 [Contig_View] POLR2L [Vega] |
| ICGC DataPortal | ENSG00000177700 |
| TCGA cBioPortal | POLR2L |
| AceView (NCBI) | POLR2L |
| Genatlas (Paris) | POLR2L |
| SOURCE (Princeton) | POLR2L |
| Genetics Home Reference (NIH) | POLR2L |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | POLR2L - chr11:839721-842529 - 11p15.5 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | POLR2L - 11p15.5 [Description] (hg19-Feb_2009) |
| GoldenPath | POLR2L - 11p15.5 [CytoView hg19] POLR2L - 11p15.5 [CytoView hg38] |
| ImmunoBase | ENSG00000177700 |
| genome Data Viewer NCBI | POLR2L [Mapview hg19] |
| OMIM | 601189 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AJ420546 AK311997 BC005903 BC018649 BQ435190 |
| RefSeq transcript (Entrez) | NM_021128 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | POLR2L |
| Alternative Splicing Gallery | ENSG00000177700 |
| Gene Expression | POLR2L [ NCBI-GEO ] POLR2L [ EBI - ARRAY_EXPRESS ]
POLR2L [ SEEK ] POLR2L [ MEM ] |
| Gene Expression Viewer (FireBrowse) | POLR2L [ Firebrowse - Broad ] |
| Genevisible | Expression of POLR2L in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5441 |
| GTEX Portal (Tissue expression) | POLR2L |
| Human Protein Atlas | ENSG00000177700-POLR2L [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P62875 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P62875 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P62875 |
| Splice isoforms : SwissVar | P62875 |
| PhosPhoSitePlus | P62875 |
| Domaine pattern : Prosite (Expaxy) | RNA_POL_N_8KD (PS01112) |
| Domains : Interpro (EBI) | RNA_pol_su_RPB10 RNA_pol_suN_Zn-BS RNAP_N/Rpb10 |
| Domain families : Pfam (Sanger) | RNA_pol_N (PF01194) |
| Domain families : Pfam (NCBI) | pfam01194 |
| Conserved Domain (NCBI) | POLR2L |
| Blocks (Seattle) | POLR2L |
| PDB (RSDB) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| PDB Europe | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| PDB (PDBSum) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| PDB (IMB) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| Structural Biology KnowledgeBase | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| SCOP (Structural Classification of Proteins) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| CATH (Classification of proteins structures) | 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L |
| Superfamily | P62875 |
| Human Protein Atlas [tissue] | ENSG00000177700-POLR2L [tissue] |
| Peptide Atlas | P62875 |
| HPRD | 01155 |
| IPI | IPI00003311 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P62875 |
| IntAct (EBI) | P62875 |
| BioGRID | POLR2L |
| STRING (EMBL) | POLR2L |
| ZODIAC | POLR2L |
| Ontologies - Pathways |
|---|
| QuickGO | P62875 |
| Ontology : AmiGO | mRNA splicing, via spliceosome DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm RNA polymerase II, core complex RNA polymerase II, core complex RNA polymerase III complex RNA polymerase I complex cytosol transcription-coupled nucleotide-excision repair transcription, DNA-templated regulation of transcription by RNA polymerase I transcription by RNA polymerase I transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription by RNA polymerase II transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping zinc ion binding fibroblast growth factor receptor signaling pathway RNA metabolic process positive regulation of type I interferon production somatic stem cell population maintenance snRNA transcription by RNA polymerase II tRNA transcription by RNA polymerase III positive regulation of gene expression, epigenetic positive regulation of viral transcription regulation of gene silencing by miRNA |
| Ontology : EGO-EBI | mRNA splicing, via spliceosome DNA binding DNA-directed 5'-3' RNA polymerase activity protein binding nucleus nucleoplasm RNA polymerase II, core complex RNA polymerase II, core complex RNA polymerase III complex RNA polymerase I complex cytosol transcription-coupled nucleotide-excision repair transcription, DNA-templated regulation of transcription by RNA polymerase I transcription by RNA polymerase I transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription by RNA polymerase II transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping zinc ion binding fibroblast growth factor receptor signaling pathway RNA metabolic process positive regulation of type I interferon production somatic stem cell population maintenance snRNA transcription by RNA polymerase II tRNA transcription by RNA polymerase III positive regulation of gene expression, epigenetic positive regulation of viral transcription regulation of gene silencing by miRNA |
| Pathways : KEGG | Purine metabolism Pyrimidine metabolism RNA polymerase Cytosolic DNA-sensing pathway Huntington's disease Epstein-Barr virus infection |
| NDEx Network | POLR2L |
| Atlas of Cancer Signalling Network | POLR2L |
| Wikipedia pathways | POLR2L |
| Orthology - Evolution |
|---|
| OrthoDB | 5441 |
| GeneTree (enSembl) | ENSG00000177700 |
| Phylogenetic Trees/Animal Genes : TreeFam | POLR2L |
| HOGENOM | P62875 |
| Homologs : HomoloGene | POLR2L |
| Homology/Alignments : Family Browser (UCSC) | POLR2L |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | POLR2L |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | POLR2L [hg38] |
| dbVar | POLR2L |
| ClinVar | POLR2L |
| Monarch | POLR2L |
| 1000_Genomes | POLR2L |
| Exome Variant Server | POLR2L |
| GNOMAD Browser | ENSG00000177700 |
| Varsome Browser | POLR2L |
| Genomic Variants (DGV) | POLR2L [DGVbeta] |
| DECIPHER | POLR2L [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | POLR2L |
| Mutations |
|---|
| ICGC Data Portal | POLR2L |
| TCGA Data Portal | POLR2L |
| Broad Tumor Portal | POLR2L |
| OASIS Portal | POLR2L [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | POLR2L [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | POLR2L |
| Mutations and Diseases : HGMD | POLR2L |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search POLR2L |
| DgiDB (Drug Gene Interaction Database) | POLR2L |
| DoCM (Curated mutations) | POLR2L (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | POLR2L (select a term) |
| intoGen | POLR2L |
| Cancer3D | POLR2L(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601189 |
| Orphanet | |
| DisGeNET | POLR2L |
| Medgen | POLR2L |
| Genetic Testing Registry | POLR2L
|
| NextProt | P62875 [Medical] |
| GENETests | POLR2L |
| Target Validation | POLR2L |
| Huge Navigator |
POLR2L [HugePedia] |
| ClinGen | POLR2L |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | POLR2L |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA33519 |
| Pharos | P62875 |
| Clinical trial | POLR2L |
| Miscellaneous |
|---|
| canSAR (ICR) | POLR2L (select the gene name) |
| Harmonizome | POLR2L |
| DataMed Index | POLR2L |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 128 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | POLR2L |
