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POLR3A (RNA polymerase III subunit A)

Identity

Alias_namespolymerase (RNA) III (DNA directed) polypeptide A
Alias_symbol (synonym)RPC1
RPC155
hRPC155
Other aliasADDH
HLD7
HGNC (Hugo) POLR3A
LocusID (NCBI) 11128
Atlas_Id 56310
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 79734907 and ends at 79789298 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPM1F (22q11.22) / POLR3A (10q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR3A   30074
Cards
Entrez_Gene (NCBI)POLR3A  11128  RNA polymerase III subunit A
AliasesADDH; HLD7; RPC1; RPC155; 
hRPC155
GeneCards (Weizmann)POLR3A
Ensembl hg19 (Hinxton)ENSG00000148606 [Gene_View]  chr10:79734907-79789298 [Contig_View]  POLR3A [Vega]
Ensembl hg38 (Hinxton)ENSG00000148606 [Gene_View]  chr10:79734907-79789298 [Contig_View]  POLR3A [Vega]
ICGC DataPortalENSG00000148606
TCGA cBioPortalPOLR3A
AceView (NCBI)POLR3A
Genatlas (Paris)POLR3A
WikiGenes11128
SOURCE (Princeton)POLR3A
Genetics Home Reference (NIH)POLR3A
Genomic and cartography
GoldenPath hg19 (UCSC)POLR3A  -     chr10:79734907-79789298 -  10q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLR3A  -     10q22.3   [Description]    (hg38-Dec_2013)
EnsemblPOLR3A - 10q22.3 [CytoView hg19]  POLR3A - 10q22.3 [CytoView hg38]
Mapping of homologs : NCBIPOLR3A [Mapview hg19]  POLR3A [Mapview hg38]
OMIM607694   614258   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_007055
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR3A
Cluster EST : UnigeneHs.436896 [ NCBI ]
CGAP (NCI)Hs.436896
Alternative Splicing GalleryENSG00000148606
Gene ExpressionPOLR3A [ NCBI-GEO ]   POLR3A [ EBI - ARRAY_EXPRESS ]   POLR3A [ SEEK ]   POLR3A [ MEM ]
Gene Expression Viewer (FireBrowse)POLR3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11128
GTEX Portal (Tissue expression)POLR3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14802   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14802  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14802
Splice isoforms : SwissVarO14802
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
PhosPhoSitePlusO14802
Domains : Interpro (EBI)RNA_pol_asu    RNA_pol_N    RNA_pol_Rpb1_1    RNA_pol_Rpb1_3    RNA_pol_Rpb1_4    RNA_pol_Rpb1_5   
Domain families : Pfam (Sanger)RNA_pol_Rpb1_1 (PF04997)    RNA_pol_Rpb1_2 (PF00623)    RNA_pol_Rpb1_3 (PF04983)    RNA_pol_Rpb1_4 (PF05000)    RNA_pol_Rpb1_5 (PF04998)   
Domain families : Pfam (NCBI)pfam04997    pfam00623    pfam04983    pfam05000    pfam04998   
Domain families : Smart (EMBL)RPOLA_N (SM00663)  
Conserved Domain (NCBI)POLR3A
DMDM Disease mutations11128
Blocks (Seattle)POLR3A
SuperfamilyO14802
Human Protein AtlasENSG00000148606
Peptide AtlasO14802
HPRD17879
IPIIPI01015730   IPI01015370   IPI00024163   
Protein Interaction databases
DIP (DOE-UCLA)O14802
IntAct (EBI)O14802
FunCoupENSG00000148606
BioGRIDPOLR3A
STRING (EMBL)POLR3A
ZODIACPOLR3A
Ontologies - Pathways
QuickGOO14802
Ontology : AmiGORNA polymerase III activity  DNA binding  chromatin binding  DNA-directed RNA polymerase activity  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription, DNA-templated  transcription from RNA polymerase III promoter  membrane  positive regulation of type I interferon production  positive regulation of interferon-beta production  innate immune response  metal ion binding  defense response to virus  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIRNA polymerase III activity  DNA binding  chromatin binding  DNA-directed RNA polymerase activity  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription, DNA-templated  transcription from RNA polymerase III promoter  membrane  positive regulation of type I interferon production  positive regulation of interferon-beta production  innate immune response  metal ion binding  defense response to virus  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Epstein-Barr virus infection   
NDEx NetworkPOLR3A
Atlas of Cancer Signalling NetworkPOLR3A
Wikipedia pathwaysPOLR3A
Orthology - Evolution
OrthoDB11128
GeneTree (enSembl)ENSG00000148606
Phylogenetic Trees/Animal Genes : TreeFamPOLR3A
HOVERGENO14802
HOGENOMO14802
Homologs : HomoloGenePOLR3A
Homology/Alignments : Family Browser (UCSC)POLR3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3A
dbVarPOLR3A
ClinVarPOLR3A
1000_GenomesPOLR3A 
Exome Variant ServerPOLR3A
ExAC (Exome Aggregation Consortium)POLR3A (select the gene name)
Genetic variants : HAPMAP11128
Genomic Variants (DGV)POLR3A [DGVbeta]
DECIPHER (Syndromes)10:79734907-79789298  ENSG00000148606
CONAN: Copy Number AnalysisPOLR3A 
Mutations
ICGC Data PortalPOLR3A 
TCGA Data PortalPOLR3A 
Broad Tumor PortalPOLR3A
OASIS PortalPOLR3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POLR3A
DgiDB (Drug Gene Interaction Database)POLR3A
DoCM (Curated mutations)POLR3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR3A (select a term)
intoGenPOLR3A
Cancer3DPOLR3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607694    614258   
Orphanet23551    23550    11107    11816   
MedgenPOLR3A
Genetic Testing Registry POLR3A
NextProtO14802 [Medical]
TSGene11128
GENETestsPOLR3A
Huge Navigator POLR3A [HugePedia]
snp3D : Map Gene to Disease11128
BioCentury BCIQPOLR3A
ClinGenPOLR3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11128
Chemical/Pharm GKB GenePA134900426
Clinical trialPOLR3A
Miscellaneous
canSAR (ICR)POLR3A (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR3A
EVEXPOLR3A
GoPubMedPOLR3A
iHOPPOLR3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:22:12 CET 2017

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