Atlas of Genetics and Cytogenetics in Oncology and Haematology

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POLR3B (RNA polymerase III subunit B)

Identity

Alias (NCBI)C128
HLD8
INMAP
RPC2
HGNC (Hugo) POLR3B
HGNC Alias symbRPC2
FLJ10388
HGNC Previous namepolymerase (RNA) III (DNA directed) polypeptide B
LocusID (NCBI) 55703
Atlas_Id 53461
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 106357748 and ends at 106510198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLR3B (12q23.3) / PDS5B (13q13.1)POLR3B 12q23.3 / PDS5B 13q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;13)(q23;q13) POLR3B/PDS5B

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Familial glioma

External links

Nomenclature
HGNC (Hugo)POLR3B   30348
Cards
Entrez_Gene (NCBI)POLR3B  55703  RNA polymerase III subunit B
AliasesC128; HLD8; INMAP; RPC2
GeneCards (Weizmann)POLR3B
Ensembl hg19 (Hinxton)ENSG00000013503 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013503 [Gene_View]  ENSG00000013503 [Sequence]  chr12:106357748-106510198 [Contig_View]  POLR3B [Vega]
ICGC DataPortalENSG00000013503
TCGA cBioPortalPOLR3B
AceView (NCBI)POLR3B
Genatlas (Paris)POLR3B
WikiGenes55703
SOURCE (Princeton)POLR3B
Genetics Home Reference (NIH)POLR3B
Genomic and cartography
GoldenPath hg38 (UCSC)POLR3B  -     chr12:106357748-106510198 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR3B  -     12q23.3   [Description]    (hg19-Feb_2009)
GoldenPathPOLR3B - 12q23.3 [CytoView hg19]  POLR3B - 12q23.3 [CytoView hg38]
ImmunoBaseENSG00000013503
genome Data Viewer NCBIPOLR3B [Mapview hg19]  
OMIM146110   607694   614366   614381   
Gene and transcription
Genbank (Entrez)AK001161 AK001250 AK090636 AK092031 AK122713
RefSeq transcript (Entrez)NM_001160708 NM_018082
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR3B
Alternative Splicing GalleryENSG00000013503
Gene ExpressionPOLR3B [ NCBI-GEO ]   POLR3B [ EBI - ARRAY_EXPRESS ]   POLR3B [ SEEK ]   POLR3B [ MEM ]
Gene Expression Viewer (FireBrowse)POLR3B [ Firebrowse - Broad ]
GenevisibleExpression of POLR3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55703
GTEX Portal (Tissue expression)POLR3B
Human Protein AtlasENSG00000013503-POLR3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NW08   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NW08  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NW08
Splice isoforms : SwissVarQ9NW08
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NW08
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNAP_su2_dom    DNA-dir_RNAP_su2_hyb_sf    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_2_sf    RNA_pol_Rpb2_3    RNA_pol_Rpb2_4    RNA_pol_Rpb2_5    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold   
Domain families : Pfam (Sanger)RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_4 (PF04566)    RNA_pol_Rpb2_5 (PF04567)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam04563    pfam04561    pfam04565    pfam04566    pfam04567    pfam00562    pfam04560   
Conserved Domain (NCBI)POLR3B
DMDM Disease mutations55703
Blocks (Seattle)POLR3B
SuperfamilyQ9NW08
Human Protein Atlas [tissue]ENSG00000013503-POLR3B [tissue]
Peptide AtlasQ9NW08
HPRD11447
IPIIPI00301346   IPI01022585   IPI01021275   IPI01022248   IPI00930490   IPI00744548   
Protein Interaction databases
DIP (DOE-UCLA)Q9NW08
IntAct (EBI)Q9NW08
FunCoupENSG00000013503
BioGRIDPOLR3B
STRING (EMBL)POLR3B
ZODIACPOLR3B
Ontologies - Pathways
QuickGOQ9NW08
Ontology : AmiGODNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleoplasm  RNA polymerase III complex  RNA polymerase III complex  cytosol  transcription, DNA-templated  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Ontology : EGO-EBIDNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleoplasm  RNA polymerase III complex  RNA polymerase III complex  cytosol  transcription, DNA-templated  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Epstein-Barr virus infection   
NDEx NetworkPOLR3B
Atlas of Cancer Signalling NetworkPOLR3B
Wikipedia pathwaysPOLR3B
Orthology - Evolution
OrthoDB55703
GeneTree (enSembl)ENSG00000013503
Phylogenetic Trees/Animal Genes : TreeFamPOLR3B
HOGENOMQ9NW08
Homologs : HomoloGenePOLR3B
Homology/Alignments : Family Browser (UCSC)POLR3B
Gene fusions - Rearrangements
Fusion : MitelmanPOLR3B/PDS5B [12q23.3/13q13.1]  
Fusion PortalPOLR3B 12q23.3 PDS5B 13q13.1 PRAD
Fusion : QuiverPOLR3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3B
dbVarPOLR3B
ClinVarPOLR3B
MonarchPOLR3B
1000_GenomesPOLR3B 
Exome Variant ServerPOLR3B
GNOMAD BrowserENSG00000013503
Varsome BrowserPOLR3B
Genetic variants : HAPMAP55703
Genomic Variants (DGV)POLR3B [DGVbeta]
DECIPHERPOLR3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR3B 
Mutations
ICGC Data PortalPOLR3B 
TCGA Data PortalPOLR3B 
Broad Tumor PortalPOLR3B
OASIS PortalPOLR3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLR3B
Mutations and Diseases : HGMDPOLR3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POLR3B
DgiDB (Drug Gene Interaction Database)POLR3B
DoCM (Curated mutations)POLR3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR3B (select a term)
intoGenPOLR3B
Cancer3DPOLR3B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146110    607694    614366    614381   
Orphanet11816   
DisGeNETPOLR3B
MedgenPOLR3B
Genetic Testing Registry POLR3B
NextProtQ9NW08 [Medical]
TSGene55703
GENETestsPOLR3B
Target ValidationPOLR3B
Huge Navigator POLR3B [HugePedia]
snp3D : Map Gene to Disease55703
BioCentury BCIQPOLR3B
ClinGenPOLR3B
Clinical trials, drugs, therapy
Protein Interactions : CTD55703
Pharm GKB GenePA134867680
Clinical trialPOLR3B
Miscellaneous
canSAR (ICR)POLR3B (select the gene name)
HarmonizomePOLR3B
DataMed IndexPOLR3B
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR3B
EVEXPOLR3B
GoPubMedPOLR3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:27:34 CEST 2020
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