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POLR3B (polymerase (RNA) III (DNA directed) polypeptide B)

Identity

Other namesC128
HLD8
RPC2
HGNC (Hugo) POLR3B
LocusID (NCBI) 55703
Location 12q23.3
Location_base_pair Starts at 106751860 and ends at 106903976 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)POLR3B   30348
Entrez_Gene (NCBI)POLR3B  55703  polymerase (RNA) III (DNA directed) polypeptide B
Cards
GeneCards (Weizmann)POLR3B
Ensembl (Hinxton)ENSG00000013503 [Gene_View]  chr12:106751860-106903976 [Contig_View]  POLR3B [Vega]
AceView (NCBI)POLR3B
Genatlas (Paris)POLR3B
SOURCE (Stanford)NM_001160708 NM_018082
Genomic and cartography
GoldenPath (UCSC)POLR3B  -  12q23.3   chr12:106751860-106903976 +  12q23.3   [Description]    (hg19-Feb_2009)
EnsemblPOLR3B - 12q23.3 [CytoView]
Mapping of homologs : NCBIPOLR3B [Mapview]
OMIM614366   614381   
Gene and transcription
Genbank (Entrez)AK001161 AK001250 AK090636 AK092031 AK122713
RefSeq transcript (SRS)NM_001160708 NM_018082
RefSeq transcript (Entrez)NM_001160708 NM_018082
RefSeq genomic (SRS)AC_000144 NC_000012 NC_018923 NG_031837 NT_029419 NW_001838061 NW_004929384
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_031837 NT_029419 NW_001838061 NW_004929384
Consensus coding sequences : CCDS (NCBI)POLR3B
Cluster EST : UnigeneHs.610795 [ SRS ] Hs.610795 [ NCBI ]
CGAP (NCI)Hs.610795
Alternative Splicing GalleryENSG00000013503
Gene ExpressionPOLR3B [ NCBI-GEO ]   POLR3B [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NW08 (SRS) Q9NW08 (Uniprot)
NextProtQ9NW08  [Medical]
With graphics : InterProQ9NW08
Splice isoforms : SwissVarQ9NW08(Swissvar)
Domaine pattern : Prosite (SRS)RNA_POL_BETA (PS01166)   
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (SRS)DNA-dir_RNA_pol_su2    DNA-dir_RNA_pol_su2_6    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_3    RNA_pol_Rpb2_4    RNA_pol_Rpb2_5    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNA_pol_su2_6    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_3    RNA_pol_Rpb2_4    RNA_pol_Rpb2_5    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold   
Related proteins : CluSTrQ9NW08
Domain families : Pfam (SRS)RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_4 (PF04566)    RNA_pol_Rpb2_5 (PF04567)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (Sanger)RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_4 (PF04566)    RNA_pol_Rpb2_5 (PF04567)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam04563    pfam04561    pfam04565    pfam04566    pfam04567    pfam00562    pfam04560   
DMDM55703
Blocks (Seattle)Q9NW08
Human Protein AtlasENSG00000013503
HPRD11447
IPIIPI00301346   IPI01022585   IPI01021275   IPI01022248   IPI00930490   IPI00744548   
Protein Interaction databases
DIP (DOE-UCLA)Q9NW08
IntAct (EBI)Q9NW08
FunCoupENSG00000013503
REACTOMEPOLR3B
Protein Interaction Database55703
BioGRIDPOLR3B
InParanoidQ9NW08
Interologous Interaction database Q9NW08
IntegromeDBPOLR3B
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)POLR3B
SNP (GeneSNP Utah)POLR3B
SNP : HGBasePOLR3B
Genetic variants : HAPMAPPOLR3B
Somatic Mutations in Cancer : COSMICPOLR3B 
CONAN: Copy Number AnalysisPOLR3B 
Mutations and Diseases : HGMDPOLR3B
OMIM614366    614381   
GENETests614366    614381   
Disease Genetic AssociationPOLR3B
Huge Navigator POLR3B [HugePedia]  POLR3B [HugeCancerGEM]
Genomic VariantsPOLR3B  POLR3B [DGVbeta]
ClinVarPOLR3B
snp3D : Map Gene to Disease55703
General knowledge
Homologs : HomoloGenePOLR3B
Homology/Alignments : Family Browser (UCSC)POLR3B
Phylogenetic Trees/Animal Genes : TreeFamPOLR3B
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.6 [ Enzyme-SRS ]   2.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
Chemical/Protein Interactions : CTD55703
Chemical/Pharm GKB GenePA134867680
Clinical trialPOLR3B
Cancer Resource (Charite)ENSG00000013503
Ontology : AmiGORNA polymerase III activity  DNA binding  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription from RNA polymerase III promoter  transcription elongation from RNA polymerase III promoter  termination of RNA polymerase III transcription  gene expression  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Ontology : EGO-EBIRNA polymerase III activity  DNA binding  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription from RNA polymerase III promoter  transcription elongation from RNA polymerase III promoter  termination of RNA polymerase III transcription  gene expression  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Pathways : KEGGPurine metabolismPyrimidine metabolismRNA polymerase
Other databases
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
PubGenePOLR3B
iHOPPOLR3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 19:33:46 CET 2013
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