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POLR3B (polymerase (RNA) III (DNA directed) polypeptide B)

Identity

Other namesC128
HLD8
RPC2
HGNC (Hugo) POLR3B
LocusID (NCBI) 55703
Location 12q23.3
Location_base_pair Starts at 106751860 and ends at 106903976 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)POLR3B   30348
Cards
Entrez_Gene (NCBI)POLR3B  55703  polymerase (RNA) III (DNA directed) polypeptide B
GeneCards (Weizmann)POLR3B
Ensembl hg19 (Hinxton)ENSG00000013503 [Gene_View]  chr12:106751860-106903976 [Contig_View]  POLR3B [Vega]
Ensembl hg38 (Hinxton)ENSG00000013503 [Gene_View]  chr12:106751860-106903976 [Contig_View]  POLR3B [Vega]
ICGC DataPortalENSG00000013503
cBioPortalPOLR3B
AceView (NCBI)POLR3B
Genatlas (Paris)POLR3B
WikiGenes55703
SOURCE (Princeton)POLR3B
Genomic and cartography
GoldenPath hg19 (UCSC)POLR3B  -     chr12:106751860-106903976 +  12q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POLR3B  -     12q23.3   [Description]    (hg38-Dec_2013)
EnsemblPOLR3B - 12q23.3 [CytoView hg19]  POLR3B - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBIPOLR3B [Mapview hg19]  POLR3B [Mapview hg38]
OMIM607694   614366   614381   
Gene and transcription
Genbank (Entrez)AK001161 AK001250 AK090636 AK092031 AK122713
RefSeq transcript (Entrez)NM_001160708 NM_018082
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_031837 NT_029419 NW_001838061 NW_004929384
Consensus coding sequences : CCDS (NCBI)POLR3B
Cluster EST : UnigeneHs.610795 [ NCBI ]
CGAP (NCI)Hs.610795
Alternative Splicing GalleryENSG00000013503
Gene ExpressionPOLR3B [ NCBI-GEO ]     POLR3B [ SEEK ]   POLR3B [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NW08 (Uniprot)
NextProtQ9NW08  [Medical]
With graphics : InterProQ9NW08
Splice isoforms : SwissVarQ9NW08 (Swissvar)
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)RNA_POL_BETA (PS01166)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_su2    DNA-dir_RNA_pol_su2_6    RNA_pol_bsu_CS    RNA_pol_bsu_protrusion    RNA_pol_Rpb2_2    RNA_pol_Rpb2_3    RNA_pol_Rpb2_4    RNA_pol_Rpb2_5    RNA_pol_Rpb2_7    RNA_pol_RPB2_OB-fold   
Related proteins : CluSTrQ9NW08
Domain families : Pfam (Sanger)RNA_pol_Rpb2_1 (PF04563)    RNA_pol_Rpb2_2 (PF04561)    RNA_pol_Rpb2_3 (PF04565)    RNA_pol_Rpb2_4 (PF04566)    RNA_pol_Rpb2_5 (PF04567)    RNA_pol_Rpb2_6 (PF00562)    RNA_pol_Rpb2_7 (PF04560)   
Domain families : Pfam (NCBI)pfam04563    pfam04561    pfam04565    pfam04566    pfam04567    pfam00562    pfam04560   
DMDM Disease mutations55703
Blocks (Seattle)Q9NW08
Human Protein AtlasENSG00000013503
Peptide AtlasQ9NW08
HPRD11447
IPIIPI00301346   IPI01022585   IPI01021275   IPI01022248   IPI00930490   IPI00744548   
Protein Interaction databases
DIP (DOE-UCLA)Q9NW08
IntAct (EBI)Q9NW08
FunCoupENSG00000013503
BioGRIDPOLR3B
IntegromeDBPOLR3B
STRING (EMBL)POLR3B
Ontologies - Pathways
QuickGOQ9NW08
Ontology : AmiGODNA binding  DNA-directed RNA polymerase activity  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription from RNA polymerase III promoter  transcription elongation from RNA polymerase III promoter  termination of RNA polymerase III transcription  gene expression  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Ontology : EGO-EBIDNA binding  DNA-directed RNA polymerase activity  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  transcription from RNA polymerase III promoter  transcription elongation from RNA polymerase III promoter  termination of RNA polymerase III transcription  gene expression  positive regulation of type I interferon production  ribonucleoside binding  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Epstein-Barr virus infection   
Protein Interaction DatabasePOLR3B
DoCM (Curated mutations)POLR3B
Wikipedia pathwaysPOLR3B
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPOLR3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3B
dbVarPOLR3B
ClinVarPOLR3B
1000_GenomesPOLR3B 
Exome Variant ServerPOLR3B
SNP (GeneSNP Utah)POLR3B
SNP : HGBasePOLR3B
Genetic variants : HAPMAPPOLR3B
Genomic VariantsPOLR3B  POLR3B [DGVbeta]
Mutations
ICGC Data PortalENSG00000013503 
Somatic Mutations in Cancer : COSMICPOLR3B 
CONAN: Copy Number AnalysisPOLR3B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:106751860-106903976
Mutations and Diseases : HGMDPOLR3B
OMIM607694    614366    614381   
MedgenPOLR3B
NextProtQ9NW08 [Medical]
GENETestsPOLR3B
Disease Genetic AssociationPOLR3B
Huge Navigator POLR3B [HugePedia]  POLR3B [HugeCancerGEM]
snp3D : Map Gene to Disease55703
DGIdb (Drug Gene Interaction db)POLR3B
General knowledge
Homologs : HomoloGenePOLR3B
Homology/Alignments : Family Browser (UCSC)POLR3B
Phylogenetic Trees/Animal Genes : TreeFamPOLR3B
Chemical/Protein Interactions : CTD55703
Chemical/Pharm GKB GenePA134867680
Clinical trialPOLR3B
Cancer Resource (Charite)ENSG00000013503
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMinePOLR3B
GoPubMedPOLR3B
iHOPPOLR3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:54:02 CET 2014
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