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POLR3C (RNA polymerase III subunit C)

Identity

Alias_namespolymerase (RNA) III (DNA directed) polypeptide C (62kD)
Alias_symbol (synonym)RPC62
RPC3
Other alias
HGNC (Hugo) POLR3C
LocusID (NCBI) 10623
Atlas_Id 72056
Location 1q21.1  [Link to chromosome band 1q21]
Location_base_pair Starts at 145824445 and ends at 145844401 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRK1 (3p25.3) / POLR3C (1q21.1)POLR3C (1q21.1) / A2M (12p13.31)POLR3C (1q21.1) / POLR3C (1q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR3C   30076
Cards
Entrez_Gene (NCBI)POLR3C  10623  RNA polymerase III subunit C
AliasesRPC3; RPC62
GeneCards (Weizmann)POLR3C
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:145824445-145844401 [Contig_View]  POLR3C [Vega]
TCGA cBioPortalPOLR3C
AceView (NCBI)POLR3C
Genatlas (Paris)POLR3C
WikiGenes10623
SOURCE (Princeton)POLR3C
Genetics Home Reference (NIH)POLR3C
Genomic and cartography
GoldenPath hg38 (UCSC)POLR3C  -     chr1:145824445-145844401 +  1q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR3C  -     1q21.1   [Description]    (hg19-Feb_2009)
EnsemblPOLR3C - 1q21.1 [CytoView hg19]  POLR3C - 1q21.1 [CytoView hg38]
Mapping of homologs : NCBIPOLR3C [Mapview hg19]  POLR3C [Mapview hg38]
OMIM617454   
Gene and transcription
Genbank (Entrez)AK223413 AY091463 BC002586 BC004424 BC053590
RefSeq transcript (Entrez)NM_001303456 NM_006468
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR3C
Cluster EST : UnigeneHs.591457 [ NCBI ]
CGAP (NCI)Hs.591457
Gene ExpressionPOLR3C [ NCBI-GEO ]   POLR3C [ EBI - ARRAY_EXPRESS ]   POLR3C [ SEEK ]   POLR3C [ MEM ]
Gene Expression Viewer (FireBrowse)POLR3C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10623
GTEX Portal (Tissue expression)POLR3C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUI4
Splice isoforms : SwissVarQ9BUI4
PhosPhoSitePlusQ9BUI4
Domains : Interpro (EBI)RNA_pol_III_RPC82-rel_HTH    RNA_pol_III_Rpc82_C   
Domain families : Pfam (Sanger)HTH_9 (PF08221)    RNA_pol_Rpc82 (PF05645)   
Domain families : Pfam (NCBI)pfam08221    pfam05645   
Conserved Domain (NCBI)POLR3C
DMDM Disease mutations10623
Blocks (Seattle)POLR3C
PDB (SRS)2XUB    2XV4    5AFQ   
PDB (PDBSum)2XUB    2XV4    5AFQ   
PDB (IMB)2XUB    2XV4    5AFQ   
PDB (RSDB)2XUB    2XV4    5AFQ   
Structural Biology KnowledgeBase2XUB    2XV4    5AFQ   
SCOP (Structural Classification of Proteins)2XUB    2XV4    5AFQ   
CATH (Classification of proteins structures)2XUB    2XV4    5AFQ   
SuperfamilyQ9BUI4
Peptide AtlasQ9BUI4
HPRD17880
IPIIPI00007948   IPI00642130   
Protein Interaction databases
DIP (DOE-UCLA)Q9BUI4
IntAct (EBI)Q9BUI4
BioGRIDPOLR3C
STRING (EMBL)POLR3C
ZODIACPOLR3C
Ontologies - Pathways
QuickGOQ9BUI4
Ontology : AmiGORNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  regulation of transcription from RNA polymerase III promoter  transcription from RNA polymerase III promoter  positive regulation of type I interferon production  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  defense response to virus  
Ontology : EGO-EBIRNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  protein binding  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  cytosol  regulation of transcription from RNA polymerase III promoter  transcription from RNA polymerase III promoter  positive regulation of type I interferon production  positive regulation of interferon-beta production  innate immune response  positive regulation of innate immune response  defense response to virus  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Epstein-Barr virus infection   
NDEx NetworkPOLR3C
Atlas of Cancer Signalling NetworkPOLR3C
Wikipedia pathwaysPOLR3C
Orthology - Evolution
OrthoDB10623
Phylogenetic Trees/Animal Genes : TreeFamPOLR3C
HOVERGENQ9BUI4
HOGENOMQ9BUI4
Homologs : HomoloGenePOLR3C
Homology/Alignments : Family Browser (UCSC)POLR3C
Gene fusions - Rearrangements
Tumor Fusion PortalPOLR3C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR3C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3C
dbVarPOLR3C
ClinVarPOLR3C
1000_GenomesPOLR3C 
Exome Variant ServerPOLR3C
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP10623
Genomic Variants (DGV)POLR3C [DGVbeta]
DECIPHERPOLR3C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR3C 
Mutations
ICGC Data PortalPOLR3C 
TCGA Data PortalPOLR3C 
Broad Tumor PortalPOLR3C
OASIS PortalPOLR3C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR3C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR3C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR3C
DgiDB (Drug Gene Interaction Database)POLR3C
DoCM (Curated mutations)POLR3C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR3C (select a term)
intoGenPOLR3C
Cancer3DPOLR3C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617454   
Orphanet
DisGeNETPOLR3C
MedgenPOLR3C
Genetic Testing Registry POLR3C
NextProtQ9BUI4 [Medical]
TSGene10623
GENETestsPOLR3C
Target ValidationPOLR3C
Huge Navigator POLR3C [HugePedia]
snp3D : Map Gene to Disease10623
BioCentury BCIQPOLR3C
ClinGenPOLR3C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10623
Chemical/Pharm GKB GenePA134870963
Clinical trialPOLR3C
Miscellaneous
canSAR (ICR)POLR3C (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR3C
EVEXPOLR3C
GoPubMedPOLR3C
iHOPPOLR3C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:02:25 CET 2017

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