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POLR3E (RNA polymerase III subunit E)

Identity

Alias (NCBI)RPC5
SIN
HGNC (Hugo) POLR3E
HGNC Alias symbRPC5
SIN
FLJ10509
HGNC Previous namepolymerase (RNA) III (DNA directed) polypeptide E (80kD)
LocusID (NCBI) 55718
Atlas_Id 72057
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 22297375 and ends at 22335103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLR3E (16p12.2) / ERGIC3 (20q11.22)POLR3E (16p12.2) / RMI2 (16p13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(p12;p13) POLR3E/RMI2

External links

Nomenclature
HGNC (Hugo)POLR3E   30347
Cards
Entrez_Gene (NCBI)POLR3E  55718  RNA polymerase III subunit E
AliasesRPC5; SIN
GeneCards (Weizmann)POLR3E
Ensembl hg19 (Hinxton)ENSG00000058600 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000058600 [Gene_View]  ENSG00000058600 [Sequence]  chr16:22297375-22335103 [Contig_View]  POLR3E [Vega]
ICGC DataPortalENSG00000058600
TCGA cBioPortalPOLR3E
AceView (NCBI)POLR3E
Genatlas (Paris)POLR3E
WikiGenes55718
SOURCE (Princeton)POLR3E
Genetics Home Reference (NIH)POLR3E
Genomic and cartography
GoldenPath hg38 (UCSC)POLR3E  -     chr16:22297375-22335103 +  16p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR3E  -     16p12.2   [Description]    (hg19-Feb_2009)
GoldenPathPOLR3E - 16p12.2 [CytoView hg19]  POLR3E - 16p12.2 [CytoView hg38]
ImmunoBaseENSG00000058600
genome Data Viewer NCBIPOLR3E [Mapview hg19]  
OMIM617815   
Gene and transcription
Genbank (Entrez)AA282721 AB040885 AK001371 AK023160 AK023231
RefSeq transcript (Entrez)NM_001258033 NM_001258034 NM_001258035 NM_001258036 NM_018119
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR3E
Alternative Splicing GalleryENSG00000058600
Gene ExpressionPOLR3E [ NCBI-GEO ]   POLR3E [ EBI - ARRAY_EXPRESS ]   POLR3E [ SEEK ]   POLR3E [ MEM ]
Gene Expression Viewer (FireBrowse)POLR3E [ Firebrowse - Broad ]
GenevisibleExpression of POLR3E in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55718
GTEX Portal (Tissue expression)POLR3E
Human Protein AtlasENSG00000058600-POLR3E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVU0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVU0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVU0
Splice isoforms : SwissVarQ9NVU0
PhosPhoSitePlusQ9NVU0
Domains : Interpro (EBI)RNA_pol_III_Rpc5   
Domain families : Pfam (Sanger)Sin_N (PF04801)   
Domain families : Pfam (NCBI)pfam04801   
Conserved Domain (NCBI)POLR3E
DMDM Disease mutations55718
Blocks (Seattle)POLR3E
SuperfamilyQ9NVU0
Human Protein Atlas [tissue]ENSG00000058600-POLR3E [tissue]
Peptide AtlasQ9NVU0
HPRD15155
IPIIPI00220045   IPI00018245   IPI00643874   IPI00221314   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVU0
IntAct (EBI)Q9NVU0
FunCoupENSG00000058600
BioGRIDPOLR3E
STRING (EMBL)POLR3E
ZODIACPOLR3E
Ontologies - Pathways
QuickGOQ9NVU0
Ontology : AmiGORNA polymerase III activity  nucleoplasm  nucleoplasm  RNA polymerase III complex  RNA polymerase III complex  cytosol  transcription by RNA polymerase III  positive regulation of type I interferon production  innate immune response  defense response to virus  
Ontology : EGO-EBIRNA polymerase III activity  nucleoplasm  nucleoplasm  RNA polymerase III complex  RNA polymerase III complex  cytosol  transcription by RNA polymerase III  positive regulation of type I interferon production  innate immune response  defense response to virus  
NDEx NetworkPOLR3E
Atlas of Cancer Signalling NetworkPOLR3E
Wikipedia pathwaysPOLR3E
Orthology - Evolution
OrthoDB55718
GeneTree (enSembl)ENSG00000058600
Phylogenetic Trees/Animal Genes : TreeFamPOLR3E
HOGENOMQ9NVU0
Homologs : HomoloGenePOLR3E
Homology/Alignments : Family Browser (UCSC)POLR3E
Gene fusions - Rearrangements
Fusion : QuiverPOLR3E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR3E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3E
dbVarPOLR3E
ClinVarPOLR3E
1000_GenomesPOLR3E 
Exome Variant ServerPOLR3E
GNOMAD BrowserENSG00000058600
Varsome BrowserPOLR3E
Genetic variants : HAPMAP55718
Genomic Variants (DGV)POLR3E [DGVbeta]
DECIPHERPOLR3E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR3E 
Mutations
ICGC Data PortalPOLR3E 
TCGA Data PortalPOLR3E 
Broad Tumor PortalPOLR3E
OASIS PortalPOLR3E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR3E  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLR3E
Mutations and Diseases : HGMDPOLR3E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR3E
DgiDB (Drug Gene Interaction Database)POLR3E
DoCM (Curated mutations)POLR3E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR3E (select a term)
intoGenPOLR3E
Cancer3DPOLR3E(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617815   
Orphanet
DisGeNETPOLR3E
MedgenPOLR3E
Genetic Testing Registry POLR3E
NextProtQ9NVU0 [Medical]
TSGene55718
GENETestsPOLR3E
Target ValidationPOLR3E
Huge Navigator POLR3E [HugePedia]
snp3D : Map Gene to Disease55718
BioCentury BCIQPOLR3E
ClinGenPOLR3E
Clinical trials, drugs, therapy
Protein Interactions : CTD55718
Pharm GKB GenePA134964025
Clinical trialPOLR3E
Miscellaneous
canSAR (ICR)POLR3E (select the gene name)
HarmonizomePOLR3E
DataMed IndexPOLR3E
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR3E
EVEXPOLR3E
GoPubMedPOLR3E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:23:35 CEST 2020
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