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POLR3H (RNA polymerase III subunit H)

Identity

Alias_namespolymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
Alias_symbol (synonym)RPC8
KIAA1665
Other aliasRPC22.9
HGNC (Hugo) POLR3H
LocusID (NCBI) 171568
Atlas_Id 72061
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 41525801 and ends at 41544489 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
POLR3H (22q13.2) / C10orf105 (10q22.1)POLR3H (22q13.2) / ENTHD1 (22q13.1)TBC1D10A (22q12.2) / POLR3H (22q13.2)
XRCC6 (22q13.2) / POLR3H (22q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLR3H   30349
Cards
Entrez_Gene (NCBI)POLR3H  171568  RNA polymerase III subunit H
AliasesRPC22.9; RPC8
GeneCards (Weizmann)POLR3H
Ensembl hg19 (Hinxton)ENSG00000100413 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100413 [Gene_View]  chr22:41525801-41544489 [Contig_View]  POLR3H [Vega]
ICGC DataPortalENSG00000100413
TCGA cBioPortalPOLR3H
AceView (NCBI)POLR3H
Genatlas (Paris)POLR3H
WikiGenes171568
SOURCE (Princeton)POLR3H
Genetics Home Reference (NIH)POLR3H
Genomic and cartography
GoldenPath hg38 (UCSC)POLR3H  -     chr22:41525801-41544489 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR3H  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblPOLR3H - 22q13.2 [CytoView hg19]  POLR3H - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBIPOLR3H [Mapview hg19]  POLR3H [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB051452 AK000365 AK026524 AK129663 AY092087
RefSeq transcript (Entrez)NM_001018050 NM_001018051 NM_001018052 NM_001282884 NM_001282885 NM_138338
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR3H
Cluster EST : UnigeneHs.712617 [ NCBI ]
CGAP (NCI)Hs.712617
Alternative Splicing GalleryENSG00000100413
Gene ExpressionPOLR3H [ NCBI-GEO ]   POLR3H [ EBI - ARRAY_EXPRESS ]   POLR3H [ SEEK ]   POLR3H [ MEM ]
Gene Expression Viewer (FireBrowse)POLR3H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)171568
GTEX Portal (Tissue expression)POLR3H
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y535   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y535  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y535
Splice isoforms : SwissVarQ9Y535
PhosPhoSitePlusQ9Y535
Domains : Interpro (EBI)NA-bd_OB-fold    RNA_pol_III_Rbc25    RNA_pol_Rpb7_N    RNAP_E/RPC8   
Domain families : Pfam (Sanger)RNA_pol_Rbc25 (PF08292)    SHS2_Rpb7-N (PF03876)   
Domain families : Pfam (NCBI)pfam08292    pfam03876   
Conserved Domain (NCBI)POLR3H
DMDM Disease mutations171568
Blocks (Seattle)POLR3H
SuperfamilyQ9Y535
Human Protein AtlasENSG00000100413
Peptide AtlasQ9Y535
HPRD15157
IPIIPI00289667   IPI00215871   IPI00442991   IPI00604415   IPI00877801   IPI01020892   IPI00877636   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y535
IntAct (EBI)Q9Y535
FunCoupENSG00000100413
BioGRIDPOLR3H
STRING (EMBL)POLR3H
ZODIACPOLR3H
Ontologies - Pathways
QuickGOQ9Y535
Ontology : AmiGORNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  centrosome  cytosol  nucleobase-containing compound metabolic process  transcription from RNA polymerase III promoter  transcription initiation from RNA polymerase III promoter  positive regulation of type I interferon production  intracellular membrane-bounded organelle  innate immune response  defense response to virus  
Ontology : EGO-EBIRNA polymerase III activity  DNA binding  DNA-directed 5'-3' RNA polymerase activity  nucleoplasm  nucleoplasm  DNA-directed RNA polymerase III complex  centrosome  cytosol  nucleobase-containing compound metabolic process  transcription from RNA polymerase III promoter  transcription initiation from RNA polymerase III promoter  positive regulation of type I interferon production  intracellular membrane-bounded organelle  innate immune response  defense response to virus  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    RNA polymerase    Cytosolic DNA-sensing pathway    Epstein-Barr virus infection   
NDEx NetworkPOLR3H
Atlas of Cancer Signalling NetworkPOLR3H
Wikipedia pathwaysPOLR3H
Orthology - Evolution
OrthoDB171568
GeneTree (enSembl)ENSG00000100413
Phylogenetic Trees/Animal Genes : TreeFamPOLR3H
HOVERGENQ9Y535
HOGENOMQ9Y535
Homologs : HomoloGenePOLR3H
Homology/Alignments : Family Browser (UCSC)POLR3H
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR3H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLR3H
dbVarPOLR3H
ClinVarPOLR3H
1000_GenomesPOLR3H 
Exome Variant ServerPOLR3H
ExAC (Exome Aggregation Consortium)POLR3H (select the gene name)
Genetic variants : HAPMAP171568
Genomic Variants (DGV)POLR3H [DGVbeta]
DECIPHERPOLR3H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR3H 
Mutations
ICGC Data PortalPOLR3H 
TCGA Data PortalPOLR3H 
Broad Tumor PortalPOLR3H
OASIS PortalPOLR3H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR3H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLR3H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POLR3H
DgiDB (Drug Gene Interaction Database)POLR3H
DoCM (Curated mutations)POLR3H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR3H (select a term)
intoGenPOLR3H
Cancer3DPOLR3H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPOLR3H
Genetic Testing Registry POLR3H
NextProtQ9Y535 [Medical]
TSGene171568
GENETestsPOLR3H
Huge Navigator POLR3H [HugePedia]
snp3D : Map Gene to Disease171568
BioCentury BCIQPOLR3H
ClinGenPOLR3H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD171568
Chemical/Pharm GKB GenePA134994174
Clinical trialPOLR3H
Miscellaneous
canSAR (ICR)POLR3H (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR3H
EVEXPOLR3H
GoPubMedPOLR3H
iHOPPOLR3H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:49:08 CEST 2017

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