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POLRMT (RNA polymerase mitochondrial)

Identity

Alias_namespolymerase (RNA) mitochondrial (DNA directed)
polymerase (RNA) mitochondrial
Alias_symbol (synonym)h-mtRPOL
APOLMT
MTRNAP
MTRPOL
Other alias
HGNC (Hugo) POLRMT
LocusID (NCBI) 5442
Atlas_Id 55684
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 617223 and ends at 633568 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLRMT (19p13.3) / PALM (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POLRMT   9200
Cards
Entrez_Gene (NCBI)POLRMT  5442  RNA polymerase mitochondrial
AliasesAPOLMT; MTRNAP; MTRPOL; h-mtRPOL
GeneCards (Weizmann)POLRMT
Ensembl hg19 (Hinxton)ENSG00000099821 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099821 [Gene_View]  chr19:617223-633568 [Contig_View]  POLRMT [Vega]
ICGC DataPortalENSG00000099821
TCGA cBioPortalPOLRMT
AceView (NCBI)POLRMT
Genatlas (Paris)POLRMT
WikiGenes5442
SOURCE (Princeton)POLRMT
Genetics Home Reference (NIH)POLRMT
Genomic and cartography
GoldenPath hg38 (UCSC)POLRMT  -     chr19:617223-633568 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLRMT  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblPOLRMT - 19p13.3 [CytoView hg19]  POLRMT - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIPOLRMT [Mapview hg19]  POLRMT [Mapview hg38]
OMIM601778   
Gene and transcription
Genbank (Entrez)AB209920 AK225723 AK225865 AK302877 AK307525
RefSeq transcript (Entrez)NM_005035
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLRMT
Cluster EST : UnigeneHs.254113 [ NCBI ]
CGAP (NCI)Hs.254113
Alternative Splicing GalleryENSG00000099821
Gene ExpressionPOLRMT [ NCBI-GEO ]   POLRMT [ EBI - ARRAY_EXPRESS ]   POLRMT [ SEEK ]   POLRMT [ MEM ]
Gene Expression Viewer (FireBrowse)POLRMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5442
GTEX Portal (Tissue expression)POLRMT
Human Protein AtlasENSG00000099821-POLRMT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00411   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00411  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00411
Splice isoforms : SwissVarO00411
Catalytic activity : Enzyme2.7.7.6 [ Enzyme-Expasy ]   2.7.7.62.7.7.6 [ IntEnz-EBI ]   2.7.7.6 [ BRENDA ]   2.7.7.6 [ KEGG ]   
PhosPhoSitePlusO00411
Domaine pattern : Prosite (Expaxy)RNA_POL_PHAGE_1 (PS00900)    RNA_POL_PHAGE_2 (PS00489)   
Domains : Interpro (EBI)DNA-dir_RNA_pol_helix_hairpin    DNA-dir_Rpol_phage-type    RPOL_N   
Domain families : Pfam (Sanger)RNA_pol (PF00940)    RPOL_N (PF14700)   
Domain families : Pfam (NCBI)pfam00940    pfam14700   
Domain families : Smart (EMBL)RPOL_N (SM01311)  
Conserved Domain (NCBI)POLRMT
DMDM Disease mutations5442
Blocks (Seattle)POLRMT
PDB (SRS)3SPA    4BOC   
PDB (PDBSum)3SPA    4BOC   
PDB (IMB)3SPA    4BOC   
PDB (RSDB)3SPA    4BOC   
Structural Biology KnowledgeBase3SPA    4BOC   
SCOP (Structural Classification of Proteins)3SPA    4BOC   
CATH (Classification of proteins structures)3SPA    4BOC   
SuperfamilyO00411
Human Protein Atlas [tissue]ENSG00000099821-POLRMT [tissue]
Peptide AtlasO00411
HPRD03468
IPIIPI00911060   IPI00298738   
Protein Interaction databases
DIP (DOE-UCLA)O00411
IntAct (EBI)O00411
FunCoupENSG00000099821
BioGRIDPOLRMT
STRING (EMBL)POLRMT
ZODIACPOLRMT
Ontologies - Pathways
QuickGOO00411
Ontology : AmiGOmitochondrial RNA polymerase core promoter sequence-specific DNA binding  RNA binding  DNA-directed 5'-3' RNA polymerase activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  mitochondrion  mitochondrial matrix  transcription from mitochondrial promoter  transcription from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  mitochondrial DNA-directed RNA polymerase complex  mitochondrial nucleoid  
Ontology : EGO-EBImitochondrial RNA polymerase core promoter sequence-specific DNA binding  RNA binding  DNA-directed 5'-3' RNA polymerase activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  mitochondrion  mitochondrial matrix  transcription from mitochondrial promoter  transcription from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  mitochondrial DNA-directed RNA polymerase complex  mitochondrial nucleoid  
NDEx NetworkPOLRMT
Atlas of Cancer Signalling NetworkPOLRMT
Wikipedia pathwaysPOLRMT
Orthology - Evolution
OrthoDB5442
GeneTree (enSembl)ENSG00000099821
Phylogenetic Trees/Animal Genes : TreeFamPOLRMT
HOVERGENO00411
HOGENOMO00411
Homologs : HomoloGenePOLRMT
Homology/Alignments : Family Browser (UCSC)POLRMT
Gene fusions - Rearrangements
Tumor Fusion PortalPOLRMT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLRMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POLRMT
dbVarPOLRMT
ClinVarPOLRMT
1000_GenomesPOLRMT 
Exome Variant ServerPOLRMT
ExAC (Exome Aggregation Consortium)ENSG00000099821
GNOMAD BrowserENSG00000099821
Genetic variants : HAPMAP5442
Genomic Variants (DGV)POLRMT [DGVbeta]
DECIPHERPOLRMT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLRMT 
Mutations
ICGC Data PortalPOLRMT 
TCGA Data PortalPOLRMT 
Broad Tumor PortalPOLRMT
OASIS PortalPOLRMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLRMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOLRMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POLRMT
DgiDB (Drug Gene Interaction Database)POLRMT
DoCM (Curated mutations)POLRMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLRMT (select a term)
intoGenPOLRMT
Cancer3DPOLRMT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601778   
Orphanet
DisGeNETPOLRMT
MedgenPOLRMT
Genetic Testing Registry POLRMT
NextProtO00411 [Medical]
TSGene5442
GENETestsPOLRMT
Target ValidationPOLRMT
Huge Navigator POLRMT [HugePedia]
snp3D : Map Gene to Disease5442
BioCentury BCIQPOLRMT
ClinGenPOLRMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5442
Chemical/Pharm GKB GenePA33522
Clinical trialPOLRMT
Miscellaneous
canSAR (ICR)POLRMT (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLRMT
EVEXPOLRMT
GoPubMedPOLRMT
iHOPPOLRMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:36 CET 2017

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