Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PON1 (paraoxonase 1)

Identity

Alias_namesPON
Alias_symbol (synonym)ESA
Other aliasMVCD5
HGNC (Hugo) PON1
LocusID (NCBI) 5444
Atlas_Id 43984
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 95297676 and ends at 95324706 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE2H (7q32.2) / PON1 (7q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PON1   9204
Cards
Entrez_Gene (NCBI)PON1  5444  paraoxonase 1
AliasesESA; MVCD5; PON
GeneCards (Weizmann)PON1
Ensembl hg19 (Hinxton)ENSG00000005421 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005421 [Gene_View]  ENSG00000005421 [Sequence]  chr7:95297676-95324706 [Contig_View]  PON1 [Vega]
ICGC DataPortalENSG00000005421
TCGA cBioPortalPON1
AceView (NCBI)PON1
Genatlas (Paris)PON1
WikiGenes5444
SOURCE (Princeton)PON1
Genetics Home Reference (NIH)PON1
Genomic and cartography
GoldenPath hg38 (UCSC)PON1  -     chr7:95297676-95324706 -  7q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PON1  -     7q21.3   [Description]    (hg19-Feb_2009)
EnsemblPON1 - 7q21.3 [CytoView hg19]  PON1 - 7q21.3 [CytoView hg38]
Mapping of homologs : NCBIPON1 [Mapview hg19]  PON1 [Mapview hg38]
OMIM168820   612633   
Gene and transcription
Genbank (Entrez)AK314027 AV652982 BC074719 BJ993711 CB122285
RefSeq transcript (Entrez)NM_000446
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PON1
Cluster EST : UnigeneHs.370995 [ NCBI ]
CGAP (NCI)Hs.370995
Alternative Splicing GalleryENSG00000005421
Gene ExpressionPON1 [ NCBI-GEO ]   PON1 [ EBI - ARRAY_EXPRESS ]   PON1 [ SEEK ]   PON1 [ MEM ]
Gene Expression Viewer (FireBrowse)PON1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5444
GTEX Portal (Tissue expression)PON1
Human Protein AtlasENSG00000005421-PON1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27169   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27169  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27169
Splice isoforms : SwissVarP27169
PhosPhoSitePlusP27169
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    Arylesterase    Paraoxonase1   
Domain families : Pfam (Sanger)Arylesterase (PF01731)   
Domain families : Pfam (NCBI)pfam01731   
Conserved Domain (NCBI)PON1
DMDM Disease mutations5444
Blocks (Seattle)PON1
PDB (SRS)1V04    1XHR   
PDB (PDBSum)1V04    1XHR   
PDB (IMB)1V04    1XHR   
PDB (RSDB)1V04    1XHR   
Structural Biology KnowledgeBase1V04    1XHR   
SCOP (Structural Classification of Proteins)1V04    1XHR   
CATH (Classification of proteins structures)1V04    1XHR   
SuperfamilyP27169
Human Protein Atlas [tissue]ENSG00000005421-PON1 [tissue]
Peptide AtlasP27169
HPRD01351
IPIIPI00218732   IPI01010259   IPI00916980   
Protein Interaction databases
DIP (DOE-UCLA)P27169
IntAct (EBI)P27169
FunCoupENSG00000005421
BioGRIDPON1
STRING (EMBL)PON1
ZODIACPON1
Ontologies - Pathways
QuickGOP27169
Ontology : AmiGOaryldialkylphosphatase activity  aryldialkylphosphatase activity  arylesterase activity  arylesterase activity  arylesterase activity  calcium ion binding  phospholipid binding  extracellular region  extracellular region  extracellular space  extracellular space  cholesterol metabolic process  response to toxic substance  positive regulation of cholesterol efflux  dephosphorylation  lipoxygenase pathway  aromatic compound catabolic process  response to nutrient levels  positive regulation of transporter activity  high-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  negative regulation of plasma lipoprotein oxidation  protein homodimerization activity  intracellular membrane-bounded organelle  carboxylic acid catabolic process  organophosphate catabolic process  phosphatidylcholine metabolic process  positive regulation of binding  extracellular exosome  response to fatty acid  blood microparticle  acyl-L-homoserine-lactone lactonohydrolase activity  response to fluoride  
Ontology : EGO-EBIaryldialkylphosphatase activity  aryldialkylphosphatase activity  arylesterase activity  arylesterase activity  arylesterase activity  calcium ion binding  phospholipid binding  extracellular region  extracellular region  extracellular space  extracellular space  cholesterol metabolic process  response to toxic substance  positive regulation of cholesterol efflux  dephosphorylation  lipoxygenase pathway  aromatic compound catabolic process  response to nutrient levels  positive regulation of transporter activity  high-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  negative regulation of plasma lipoprotein oxidation  protein homodimerization activity  intracellular membrane-bounded organelle  carboxylic acid catabolic process  organophosphate catabolic process  phosphatidylcholine metabolic process  positive regulation of binding  extracellular exosome  response to fatty acid  blood microparticle  acyl-L-homoserine-lactone lactonohydrolase activity  response to fluoride  
NDEx NetworkPON1
Atlas of Cancer Signalling NetworkPON1
Wikipedia pathwaysPON1
Orthology - Evolution
OrthoDB5444
GeneTree (enSembl)ENSG00000005421
Phylogenetic Trees/Animal Genes : TreeFamPON1
HOVERGENP27169
HOGENOMP27169
Homologs : HomoloGenePON1
Homology/Alignments : Family Browser (UCSC)PON1
Gene fusions - Rearrangements
Fusion : QuiverPON1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPON1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PON1
dbVarPON1
ClinVarPON1
1000_GenomesPON1 
Exome Variant ServerPON1
ExAC (Exome Aggregation Consortium)ENSG00000005421
GNOMAD BrowserENSG00000005421
Varsome BrowserPON1
Genetic variants : HAPMAP5444
Genomic Variants (DGV)PON1 [DGVbeta]
DECIPHERPON1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPON1 
Mutations
ICGC Data PortalPON1 
TCGA Data PortalPON1 
Broad Tumor PortalPON1
OASIS PortalPON1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPON1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPON1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PON1
DgiDB (Drug Gene Interaction Database)PON1
DoCM (Curated mutations)PON1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PON1 (select a term)
intoGenPON1
Cancer3DPON1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM168820    612633   
Orphanet106   
DisGeNETPON1
MedgenPON1
Genetic Testing Registry PON1
NextProtP27169 [Medical]
TSGene5444
GENETestsPON1
Target ValidationPON1
Huge Navigator PON1 [HugePedia]
snp3D : Map Gene to Disease5444
BioCentury BCIQPON1
ClinGenPON1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5444
Chemical/Pharm GKB GenePA33529
Clinical trialPON1
Miscellaneous
canSAR (ICR)PON1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePON1
EVEXPON1
GoPubMedPON1
iHOPPON1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 11:31:17 CET 2018
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