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PON3 (paraoxonase 3)

Identity

Other alias-
HGNC (Hugo) PON3
LocusID (NCBI) 5446
Atlas_Id 53436
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 95359872 and ends at 95396375 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PON3   9206
Cards
Entrez_Gene (NCBI)PON3  5446  paraoxonase 3
Aliases
GeneCards (Weizmann)PON3
Ensembl hg19 (Hinxton)ENSG00000105852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105852 [Gene_View]  ENSG00000105852 [Sequence]  chr7:95359872-95396375 [Contig_View]  PON3 [Vega]
ICGC DataPortalENSG00000105852
TCGA cBioPortalPON3
AceView (NCBI)PON3
Genatlas (Paris)PON3
WikiGenes5446
SOURCE (Princeton)PON3
Genetics Home Reference (NIH)PON3
Genomic and cartography
GoldenPath hg38 (UCSC)PON3  -     chr7:95359872-95396375 -  7q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PON3  -     7q21.3   [Description]    (hg19-Feb_2009)
EnsemblPON3 - 7q21.3 [CytoView hg19]  PON3 - 7q21.3 [CytoView hg38]
Mapping of homologs : NCBIPON3 [Mapview hg19]  PON3 [Mapview hg38]
OMIM602720   
Gene and transcription
Genbank (Entrez)AA860930 AF320003 AF329433 AK096114 AK304282
RefSeq transcript (Entrez)NM_000940
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PON3
Cluster EST : UnigeneHs.440967 [ NCBI ]
CGAP (NCI)Hs.440967
Alternative Splicing GalleryENSG00000105852
Gene ExpressionPON3 [ NCBI-GEO ]   PON3 [ EBI - ARRAY_EXPRESS ]   PON3 [ SEEK ]   PON3 [ MEM ]
Gene Expression Viewer (FireBrowse)PON3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5446
GTEX Portal (Tissue expression)PON3
Human Protein AtlasENSG00000105852-PON3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15166   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15166  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15166
Splice isoforms : SwissVarQ15166
Catalytic activity : Enzyme3.1.1.2 [ Enzyme-Expasy ]   3.1.1.23.1.1.2 [ IntEnz-EBI ]   3.1.1.2 [ BRENDA ]   3.1.1.2 [ KEGG ]   
PhosPhoSitePlusQ15166
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    Arylesterase    Paraoxonase2   
Domain families : Pfam (Sanger)Arylesterase (PF01731)   
Domain families : Pfam (NCBI)pfam01731   
Conserved Domain (NCBI)PON3
DMDM Disease mutations5446
Blocks (Seattle)PON3
SuperfamilyQ15166
Human Protein Atlas [tissue]ENSG00000105852-PON3 [tissue]
Peptide AtlasQ15166
HPRD04098
IPIIPI00299778   IPI00924890   IPI00924485   IPI00925130   IPI00925429   
Protein Interaction databases
DIP (DOE-UCLA)Q15166
IntAct (EBI)Q15166
FunCoupENSG00000105852
BioGRIDPON3
STRING (EMBL)PON3
ZODIACPON3
Ontologies - Pathways
QuickGOQ15166
Ontology : AmiGOaryldialkylphosphatase activity  arylesterase activity  arylesterase activity  arylesterase activity  extracellular region  extracellular space  response to toxic substance  phenylacetate catabolic process  dephosphorylation  3,4-dihydrocoumarin hydrolase activity  lipoxygenase pathway  aromatic compound catabolic process  negative regulation of superoxide anion generation  protein homodimerization activity  intracellular membrane-bounded organelle  coumarin catabolic process  carboxylic acid catabolic process  metal ion binding  extracellular exosome  acyl-L-homoserine-lactone lactonohydrolase activity  
Ontology : EGO-EBIaryldialkylphosphatase activity  arylesterase activity  arylesterase activity  arylesterase activity  extracellular region  extracellular space  response to toxic substance  phenylacetate catabolic process  dephosphorylation  3,4-dihydrocoumarin hydrolase activity  lipoxygenase pathway  aromatic compound catabolic process  negative regulation of superoxide anion generation  protein homodimerization activity  intracellular membrane-bounded organelle  coumarin catabolic process  carboxylic acid catabolic process  metal ion binding  extracellular exosome  acyl-L-homoserine-lactone lactonohydrolase activity  
NDEx NetworkPON3
Atlas of Cancer Signalling NetworkPON3
Wikipedia pathwaysPON3
Orthology - Evolution
OrthoDB5446
GeneTree (enSembl)ENSG00000105852
Phylogenetic Trees/Animal Genes : TreeFamPON3
HOVERGENQ15166
HOGENOMQ15166
Homologs : HomoloGenePON3
Homology/Alignments : Family Browser (UCSC)PON3
Gene fusions - Rearrangements
Fusion : QuiverPON3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPON3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PON3
dbVarPON3
ClinVarPON3
1000_GenomesPON3 
Exome Variant ServerPON3
ExAC (Exome Aggregation Consortium)ENSG00000105852
GNOMAD BrowserENSG00000105852
Varsome BrowserPON3
Genetic variants : HAPMAP5446
Genomic Variants (DGV)PON3 [DGVbeta]
DECIPHERPON3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPON3 
Mutations
ICGC Data PortalPON3 
TCGA Data PortalPON3 
Broad Tumor PortalPON3
OASIS PortalPON3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPON3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPON3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PON3
DgiDB (Drug Gene Interaction Database)PON3
DoCM (Curated mutations)PON3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PON3 (select a term)
intoGenPON3
Cancer3DPON3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602720   
Orphanet106   
DisGeNETPON3
MedgenPON3
Genetic Testing Registry PON3
NextProtQ15166 [Medical]
TSGene5446
GENETestsPON3
Target ValidationPON3
Huge Navigator PON3 [HugePedia]
snp3D : Map Gene to Disease5446
BioCentury BCIQPON3
ClinGenPON3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5446
Chemical/Pharm GKB GenePA33531
Clinical trialPON3
Miscellaneous
canSAR (ICR)PON3 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePON3
EVEXPON3
GoPubMedPON3
iHOPPON3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:31:18 CET 2018

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