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POR (cytochrome p450 oxidoreductase)

Identity

Alias (NCBI)CPR
CYPOR
P450R
HGNC (Hugo) POR
HGNC Alias symbCYPOR
FLJ26468
HGNC Alias nameNADPH--hemoprotein reductase
HGNC Previous nameP450 (cytochrome) oxidoreductase
LocusID (NCBI) 5447
Atlas_Id 41787
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 75915155 and ends at 75986855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LAPTM5 (1p35.2) / POR (7q11.23)POR (7q11.23) / ATP2B4 (1q32.1)POR (7q11.23) / PIBF1 (13q22.1)
SLC38A2 (12q13.11) / POR (7q11.23)POR 7q11.23 / PIBF1 13q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)POR   9208
Cards
Entrez_Gene (NCBI)POR    cytochrome p450 oxidoreductase
AliasesCPR; CYPOR; P450R
GeneCards (Weizmann)POR
Ensembl hg19 (Hinxton)ENSG00000127948 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127948 [Gene_View]  ENSG00000127948 [Sequence]  chr7:75915155-75986855 [Contig_View]  POR [Vega]
ICGC DataPortalENSG00000127948
TCGA cBioPortalPOR
AceView (NCBI)POR
Genatlas (Paris)POR
SOURCE (Princeton)POR
Genetics Home Reference (NIH)POR
Genomic and cartography
GoldenPath hg38 (UCSC)POR  -     chr7:75915155-75986855 +  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POR  -     7q11.23   [Description]    (hg19-Feb_2009)
GoldenPathPOR - 7q11.23 [CytoView hg19]  POR - 7q11.23 [CytoView hg38]
ImmunoBaseENSG00000127948
Genome Data Viewer NCBIPOR [Mapview hg19]  
OMIM124015   201750   207410   613571   
Gene and transcription
Genbank (Entrez)AB051763 AB209874 AF258341 AK129978 AK290529
RefSeq transcript (Entrez)NM_000941 NM_001367562 NM_001382655 NM_001382657 NM_001382658 NM_001382659 NM_001382662
Consensus coding sequences : CCDS (NCBI)POR
Gene ExpressionPOR [ NCBI-GEO ]   POR [ EBI - ARRAY_EXPRESS ]   POR [ SEEK ]   POR [ MEM ]
Gene Expression Viewer (FireBrowse)POR [ Firebrowse - Broad ]
GenevisibleExpression of POR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5447
GTEX Portal (Tissue expression)POR
Human Protein AtlasENSG00000127948-POR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16435   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16435  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16435
PhosPhoSitePlusP16435
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)    FLAVODOXIN_LIKE (PS50902)   
Domains : Interpro (EBI)CysJ-like_FAD-binding    FAD-bd_FR_type    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprot_Pyr_Nucl_cyt_Rdtase    Flavoprotein-like_sf    FNR_nucleotide-bd    NADPH_Cyt_P450_Rdtase_alpha    OxRdtase_FAD/NAD-bd    P450R    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_1 (PF00667)    Flavodoxin_1 (PF00258)    NAD_binding_1 (PF00175)   
Domain families : Pfam (NCBI)pfam00667    pfam00258    pfam00175   
Conserved Domain (NCBI)POR
PDB (RSDB)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
PDB Europe1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
PDB (PDBSum)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
PDB (IMB)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
Structural Biology KnowledgeBase1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
SCOP (Structural Classification of Proteins)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
CATH (Classification of proteins structures)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT    5EMN    5FA6   
SuperfamilyP16435
AlphaFold pdb e-kbP16435   
Human Protein Atlas [tissue]ENSG00000127948-POR [tissue]
HPRD00485
Protein Interaction databases
DIP (DOE-UCLA)P16435
IntAct (EBI)P16435
BioGRIDPOR
STRING (EMBL)POR
ZODIACPOR
Ontologies - Pathways
QuickGOP16435
Ontology : AmiGOregulation of growth plate cartilage chondrocyte proliferation  NADPH-hemoprotein reductase activity  NADPH-hemoprotein reductase activity  cytochrome-b5 reductase activity, acting on NAD(P)H  protein binding  mitochondrion  endoplasmic reticulum membrane  cytosol  xenobiotic metabolic process  response to nutrient  nitric oxide dioxygenase activity  electron transfer activity  carnitine metabolic process  response to hormone  flavonoid metabolic process  FMN binding  membrane  integral component of membrane  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  hydrolase activity  internal peptidyl-lysine acetylation  fatty acid oxidation  enzyme binding  electron transport chain  positive regulation of chondrocyte differentiation  positive regulation of monooxygenase activity  response to drug  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  nitrate catabolic process  positive regulation of cholesterol biosynthetic process  positive regulation of smoothened signaling pathway  nitric oxide catabolic process  iron-cytochrome-c reductase activity  flavin adenine dinucleotide binding  NADP binding  negative regulation of lipase activity  demethylation  cellular response to follicle-stimulating hormone stimulus  cellular response to peptide hormone stimulus  positive regulation of steroid hormone biosynthetic process  cellular organofluorine metabolic process  
Ontology : EGO-EBIregulation of growth plate cartilage chondrocyte proliferation  NADPH-hemoprotein reductase activity  NADPH-hemoprotein reductase activity  cytochrome-b5 reductase activity, acting on NAD(P)H  protein binding  mitochondrion  endoplasmic reticulum membrane  cytosol  xenobiotic metabolic process  response to nutrient  nitric oxide dioxygenase activity  electron transfer activity  carnitine metabolic process  response to hormone  flavonoid metabolic process  FMN binding  membrane  integral component of membrane  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  hydrolase activity  internal peptidyl-lysine acetylation  fatty acid oxidation  enzyme binding  electron transport chain  positive regulation of chondrocyte differentiation  positive regulation of monooxygenase activity  response to drug  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  nitrate catabolic process  positive regulation of cholesterol biosynthetic process  positive regulation of smoothened signaling pathway  nitric oxide catabolic process  iron-cytochrome-c reductase activity  flavin adenine dinucleotide binding  NADP binding  negative regulation of lipase activity  demethylation  cellular response to follicle-stimulating hormone stimulus  cellular response to peptide hormone stimulus  positive regulation of steroid hormone biosynthetic process  cellular organofluorine metabolic process  
Pathways : BIOCARTAOxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
NDEx NetworkPOR
Atlas of Cancer Signalling NetworkPOR
Wikipedia pathwaysPOR
Orthology - Evolution
OrthoDB5447
GeneTree (enSembl)ENSG00000127948
Phylogenetic Trees/Animal Genes : TreeFamPOR
Homologs : HomoloGenePOR
Homology/Alignments : Family Browser (UCSC)POR
Gene fusions - Rearrangements
Fusion : MitelmanPOR/PIBF1 [7q11.23/13q22.1]  
Fusion : QuiverPOR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POR
dbVarPOR
ClinVarPOR
MonarchPOR
1000_GenomesPOR 
Exome Variant ServerPOR
GNOMAD BrowserENSG00000127948
Varsome BrowserPOR
ACMGPOR variants
VarityP16435
Genomic Variants (DGV)POR [DGVbeta]
DECIPHERPOR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOR 
Mutations
ICGC Data PortalPOR 
TCGA Data PortalPOR 
Broad Tumor PortalPOR
OASIS PortalPOR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOR
Mutations and Diseases : HGMDPOR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPOR
DgiDB (Drug Gene Interaction Database)POR
DoCM (Curated mutations)POR
CIViC (Clinical Interpretations of Variants in Cancer)POR
Cancer3DPOR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124015    201750    207410    613571   
Orphanet12654   
DisGeNETPOR
MedgenPOR
Genetic Testing Registry POR
NextProtP16435 [Medical]
GENETestsPOR
Target ValidationPOR
Huge Navigator POR [HugePedia]
ClinGenPOR
Clinical trials, drugs, therapy
MyCancerGenomePOR
Protein Interactions : CTDPOR
Pharm GKB GenePA33532
Pharm GKB PathwaysPA165292177   PA165859361   
PharosP16435
Clinical trialPOR
Miscellaneous
canSAR (ICR)POR
HarmonizomePOR
DataMed IndexPOR
Probes
Litterature
PubMed209 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPOR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:12 CEST 2021

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