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POR (P450 (cytochrome) oxidoreductase)

Identity

Other namesCPR
CYPOR
P450R
HGNC (Hugo) POR
LocusID (NCBI) 5447
Location 7q11.23
Location_base_pair Starts at 75544420 and ends at 75616173 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)POR   9208
Cards
Entrez_Gene (NCBI)POR  5447  P450 (cytochrome) oxidoreductase
GeneCards (Weizmann)POR
Ensembl (Hinxton)ENSG00000127948 [Gene_View]  chr7:75544420-75616173 [Contig_View]  POR [Vega]
AceView (NCBI)POR
Genatlas (Paris)POR
WikiGenes5447
SOURCE (Princeton)NM_000941
Genomic and cartography
GoldenPath (UCSC)POR  -  7q11.23   chr7:75544420-75616173 +  7q11.23   [Description]    (hg19-Feb_2009)
EnsemblPOR - 7q11.23 [CytoView]
Mapping of homologs : NCBIPOR [Mapview]
OMIM124015   201750   613571   
Gene and transcription
Genbank (Entrez)AB051763 AB209874 AF258341 AK129978 AK290529
RefSeq transcript (Entrez)NM_000941
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_008930 NT_007933 NT_079595 NW_001839047 NW_003871064 NW_004929332
Consensus coding sequences : CCDS (NCBI)POR
Cluster EST : UnigeneHs.354056 [ NCBI ]
CGAP (NCI)Hs.354056
Alternative Splicing : Fast-db (Paris)GSHG0027459
Alternative Splicing GalleryENSG00000127948
Gene ExpressionPOR [ NCBI-GEO ]     POR [ SEEK ]   POR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16435 (Uniprot)
NextProtP16435  [Medical]
With graphics : InterProP16435
Splice isoforms : SwissVarP16435 (Swissvar)
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)    FLAVODOXIN_LIKE (PS50902)   
Domains : Interpro (EBI)FAD-binding_1    Fd_Rdtase_FAD-bd    Flavdoxin    Flavodoxin/NO_synth    Flavoprot_Pyr_Nucl_cyt_Rdtase    NADPH_Cyt_P450_Rdtase_dom3    OxRdtase_FAD/NAD-bd    P450R    Riboflavin_synthase-like_b-brl   
Related proteins : CluSTrP16435
Domain families : Pfam (Sanger)FAD_binding_1 (PF00667)    Flavodoxin_1 (PF00258)    NAD_binding_1 (PF00175)   
Domain families : Pfam (NCBI)pfam00667    pfam00258    pfam00175   
DMDM Disease mutations5447
Blocks (Seattle)P16435
PDB (SRS)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT   
PDB (PDBSum)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT   
PDB (IMB)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT   
PDB (RSDB)1B1C    3FJO    3QE2    3QFC    3QFR    3QFS    3QFT   
Human Protein AtlasENSG00000127948
Peptide AtlasP16435
HPRD00485
IPIIPI00470467   IPI00927647   IPI00910178   IPI00908675   IPI01010631   IPI00852820   IPI00853510   IPI00792395   IPI00852905   IPI00903331   IPI00924812   IPI00973067   IPI00927126   IPI00925752   IPI00925466   IPI00926806   IPI00924702   IPI00924439   
Protein Interaction databases
DIP (DOE-UCLA)P16435
IntAct (EBI)P16435
FunCoupENSG00000127948
BioGRIDPOR
InParanoidP16435
Interologous Interaction database P16435
IntegromeDBPOR
STRING (EMBL)POR
Ontologies - Pathways
Ontology : AmiGOregulation of growth plate cartilage chondrocyte proliferation  NADPH-hemoprotein reductase activity  NADPH-hemoprotein reductase activity  cytochrome-b5 reductase activity, acting on NAD(P)H  iron ion binding  protein binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  response to nutrient  electron carrier activity  carnitine metabolic process  flavonoid metabolic process  FMN binding  hydrolase activity  internal peptidyl-lysine acetylation  fatty acid oxidation  enzyme binding  positive regulation of chondrocyte differentiation  positive regulation of monooxygenase activity  response to drug  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  nitrate catabolic process  positive regulation of cholesterol biosynthetic process  positive regulation of smoothened signaling pathway  nitric oxide catabolic process  iron-cytochrome-c reductase activity  flavin adenine dinucleotide binding  NADP binding  oxidation-reduction process  oxidation-reduction process  negative regulation of lipase activity  demethylation  cellular response to follicle-stimulating hormone stimulus  cellular response to peptide hormone stimulus  positive regulation of steroid hormone biosynthetic process  cellular organofluorine metabolic process  
Ontology : EGO-EBIregulation of growth plate cartilage chondrocyte proliferation  NADPH-hemoprotein reductase activity  NADPH-hemoprotein reductase activity  cytochrome-b5 reductase activity, acting on NAD(P)H  iron ion binding  protein binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  response to nutrient  electron carrier activity  carnitine metabolic process  flavonoid metabolic process  FMN binding  hydrolase activity  internal peptidyl-lysine acetylation  fatty acid oxidation  enzyme binding  positive regulation of chondrocyte differentiation  positive regulation of monooxygenase activity  response to drug  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  nitrate catabolic process  positive regulation of cholesterol biosynthetic process  positive regulation of smoothened signaling pathway  nitric oxide catabolic process  iron-cytochrome-c reductase activity  flavin adenine dinucleotide binding  NADP binding  oxidation-reduction process  oxidation-reduction process  negative regulation of lipase activity  demethylation  cellular response to follicle-stimulating hormone stimulus  cellular response to peptide hormone stimulus  positive regulation of steroid hormone biosynthetic process  cellular organofluorine metabolic process  
Pathways : BIOCARTAOxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
REACTOMEPOR
Protein Interaction DatabasePOR
Wikipedia pathwaysPOR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)POR
SNP (GeneSNP Utah)POR
SNP : HGBasePOR
Genetic variants : HAPMAPPOR
1000_GenomesPOR 
ICGC programENSG00000127948 
Somatic Mutations in Cancer : COSMICPOR 
CONAN: Copy Number AnalysisPOR 
Mutations and Diseases : HGMDPOR
OMIM124015    201750    613571   
GENETestsPOR
Disease Genetic AssociationPOR
Huge Navigator POR [HugePedia]  POR [HugeCancerGEM]
Genomic VariantsPOR  POR [DGVbeta]
Exome VariantPOR
dbVarPOR
ClinVarPOR
snp3D : Map Gene to Disease5447
General knowledge
Homologs : HomoloGenePOR
Homology/Alignments : Family Browser (UCSC)POR
Phylogenetic Trees/Animal Genes : TreeFamPOR
Chemical/Protein Interactions : CTD5447
Chemical/Pharm GKB GenePA33532
Clinical trialPOR
Cancer Resource (Charite)ENSG00000127948
Other databases
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
CoreMinePOR
iHOPPOR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:23:04 CEST 2014

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