Atlas of Genetics and Cytogenetics in Oncology and Haematology


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POSTN (periostin)

Identity

Alias_namesperiostin
Alias_symbol (synonym)OSF-2
PN
periostin
Other aliasOSF2
PDLPOSTN
HGNC (Hugo) POSTN
LocusID (NCBI) 10631
Atlas_Id 46198
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 37562582 and ends at 37598844 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COL6A3 (2q37.3) / POSTN (13q13.3)COX7A1 (19q13.12) / POSTN (13q13.3)POSTN (13q13.3) / NCAM1 (11q23.2)
POSTN (13q13.3) / POSTN (13q13.3)POSTN (13q13.3) / TM9SF3 (10q24.1)POSTN (13q13.3) / TRIM33 (1p13.2)
POSTN (13q13.3) / YY1 (14q32.2)RPS6 (9p22.1) / POSTN (13q13.3)POSTN 13q13.3 / YY1 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POSTN   16953
Cards
Entrez_Gene (NCBI)POSTN  10631  periostin
AliasesOSF-2; OSF2; PDLPOSTN; PN
GeneCards (Weizmann)POSTN
Ensembl hg19 (Hinxton)ENSG00000133110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133110 [Gene_View]  chr13:37562582-37598844 [Contig_View]  POSTN [Vega]
ICGC DataPortalENSG00000133110
TCGA cBioPortalPOSTN
AceView (NCBI)POSTN
Genatlas (Paris)POSTN
WikiGenes10631
SOURCE (Princeton)POSTN
Genetics Home Reference (NIH)POSTN
Genomic and cartography
GoldenPath hg38 (UCSC)POSTN  -     chr13:37562582-37598844 -  13q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POSTN  -     13q13.3   [Description]    (hg19-Feb_2009)
EnsemblPOSTN - 13q13.3 [CytoView hg19]  POSTN - 13q13.3 [CytoView hg38]
Mapping of homologs : NCBIPOSTN [Mapview hg19]  POSTN [Mapview hg38]
OMIM608777   
Gene and transcription
Genbank (Entrez)AI580215 AK021444 AK297914 AK300261 AK304640
RefSeq transcript (Entrez)NM_001135934 NM_001135935 NM_001135936 NM_001286665 NM_001286666 NM_001286667 NM_001330517 NM_006475
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POSTN
Cluster EST : UnigeneHs.721018 [ NCBI ]
CGAP (NCI)Hs.721018
Alternative Splicing GalleryENSG00000133110
Gene ExpressionPOSTN [ NCBI-GEO ]   POSTN [ EBI - ARRAY_EXPRESS ]   POSTN [ SEEK ]   POSTN [ MEM ]
Gene Expression Viewer (FireBrowse)POSTN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10631
GTEX Portal (Tissue expression)POSTN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15063   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15063  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15063
Splice isoforms : SwissVarQ15063
PhosPhoSitePlusQ15063
Domaine pattern : Prosite (Expaxy)EMI (PS51041)    FAS1 (PS50213)   
Domains : Interpro (EBI)EMI_domain    FAS1_domain    TGFBI/POSTN   
Domain families : Pfam (Sanger)Fasciclin (PF02469)   
Domain families : Pfam (NCBI)pfam02469   
Domain families : Smart (EMBL)FAS1 (SM00554)  
Conserved Domain (NCBI)POSTN
DMDM Disease mutations10631
Blocks (Seattle)POSTN
SuperfamilyQ15063
Human Protein AtlasENSG00000133110
Peptide AtlasQ15063
HPRD12295
IPIIPI00007960   IPI00218585   IPI01009588   IPI00910262   IPI01010099   IPI00410241   IPI00641231   
Protein Interaction databases
DIP (DOE-UCLA)Q15063
IntAct (EBI)Q15063
FunCoupENSG00000133110
BioGRIDPOSTN
STRING (EMBL)POSTN
ZODIACPOSTN
Ontologies - Pathways
QuickGOQ15063
Ontology : AmiGOskeletal system development  response to hypoxia  negative regulation of cell-matrix adhesion  regulation of systemic arterial blood pressure  protein binding  proteinaceous extracellular matrix  extracellular space  trans-Golgi network  cell adhesion  heparin binding  regulation of Notch signaling pathway  response to mechanical stimulus  response to muscle activity  positive regulation of smooth muscle cell migration  extracellular matrix organization  extracellular matrix  extracellular matrix  neuromuscular junction  response to estradiol  cellular response to fibroblast growth factor stimulus  metal ion binding  cellular response to vitamin K  cellular response to tumor necrosis factor  cellular response to transforming growth factor beta stimulus  negative regulation of substrate adhesion-dependent cell spreading  positive regulation of chemokine (C-C motif) ligand 2 secretion  neuron projection extension  bone regeneration  
Ontology : EGO-EBIskeletal system development  response to hypoxia  negative regulation of cell-matrix adhesion  regulation of systemic arterial blood pressure  protein binding  proteinaceous extracellular matrix  extracellular space  trans-Golgi network  cell adhesion  heparin binding  regulation of Notch signaling pathway  response to mechanical stimulus  response to muscle activity  positive regulation of smooth muscle cell migration  extracellular matrix organization  extracellular matrix  extracellular matrix  neuromuscular junction  response to estradiol  cellular response to fibroblast growth factor stimulus  metal ion binding  cellular response to vitamin K  cellular response to tumor necrosis factor  cellular response to transforming growth factor beta stimulus  negative regulation of substrate adhesion-dependent cell spreading  positive regulation of chemokine (C-C motif) ligand 2 secretion  neuron projection extension  bone regeneration  
NDEx NetworkPOSTN
Atlas of Cancer Signalling NetworkPOSTN
Wikipedia pathwaysPOSTN
Orthology - Evolution
OrthoDB10631
GeneTree (enSembl)ENSG00000133110
Phylogenetic Trees/Animal Genes : TreeFamPOSTN
HOVERGENQ15063
HOGENOMQ15063
Homologs : HomoloGenePOSTN
Homology/Alignments : Family Browser (UCSC)POSTN
Gene fusions - Rearrangements
Fusion : MitelmanPOSTN/TM9SF3 [13q13.3/10q24.1]  
Fusion : MitelmanPOSTN/TRIM33 [13q13.3/1p13.2]  [t(1;3)(p13;q13)]  
Fusion : MitelmanPOSTN/YY1 [13q13.3/14q32.2]  [t(3;14)(q13;q32)]  
Fusion: TCGAPOSTN 13q13.3 YY1 14q32.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOSTN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POSTN
dbVarPOSTN
ClinVarPOSTN
1000_GenomesPOSTN 
Exome Variant ServerPOSTN
ExAC (Exome Aggregation Consortium)POSTN (select the gene name)
Genetic variants : HAPMAP10631
Genomic Variants (DGV)POSTN [DGVbeta]
DECIPHERPOSTN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOSTN 
Mutations
ICGC Data PortalPOSTN 
TCGA Data PortalPOSTN 
Broad Tumor PortalPOSTN
OASIS PortalPOSTN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOSTN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOSTN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POSTN
DgiDB (Drug Gene Interaction Database)POSTN
DoCM (Curated mutations)POSTN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POSTN (select a term)
intoGenPOSTN
Cancer3DPOSTN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608777   
Orphanet
MedgenPOSTN
Genetic Testing Registry POSTN
NextProtQ15063 [Medical]
TSGene10631
GENETestsPOSTN
Target ValidationPOSTN
Huge Navigator POSTN [HugePedia]
snp3D : Map Gene to Disease10631
BioCentury BCIQPOSTN
ClinGenPOSTN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10631
Chemical/Pharm GKB GenePA134900304
Clinical trialPOSTN
Miscellaneous
canSAR (ICR)POSTN (select the gene name)
Probes
Litterature
PubMed203 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOSTN
EVEXPOSTN
GoPubMedPOSTN
iHOPPOSTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:24 CEST 2017

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