POU2F1 (POU class 2 homeobox 1)

2007-02-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
OCT1,OTF1,Oct1Z,oct-1B
FUSION GENES

Other Information

Locus ID:

NCBI: 5451
MIM: 164175
HGNC: 9212
Ensembl: ENSG00000143190

Variants:

dbSNP: 5451
ClinVar: 5451
TCGA: ENSG00000143190
COSMIC: POU2F1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143190ENST00000271411Q16075
ENSG00000143190ENST00000367862P14859
ENSG00000143190ENST00000367866P14859
ENSG00000143190ENST00000420254A0A0A0MT46
ENSG00000143190ENST00000429375P14859
ENSG00000143190ENST00000442313A0A0A0MSV5
ENSG00000143190ENST00000443275A0A0C4DG88
ENSG00000143190ENST00000541643P14859
ENSG00000143190ENST00000541643A0A024R8Y2
ENSG00000143190ENST00000560232Q16075

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128879262003S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.172
214446902011Replication stress induces 53BP1-containing OPT domains in G1 cells.130
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120192092002Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.60
145598932004Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.57
191747802009Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.52
163012152005T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.48
191717822009A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.47
276587742016Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression.46

Citation

Dessen P

POU2F1 (POU class 2 homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46218/pou2f1