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POU2F2 (POU class 2 homeobox 2)

Identity

Other namesOCT2
OTF2
Oct-2
HGNC (Hugo) POU2F2
LocusID (NCBI) 5452
Atlas_Id 46573
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 42590262 and ends at 42636625 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
POU2F2 (19q13.2) / POU2F2 (19q13.2)PTPRS (19p13.3) / POU2F2 (19q13.2)PTPRS 19p13.3 / POU2F2 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POU2F2   9213
Cards
Entrez_Gene (NCBI)POU2F2  5452  POU class 2 homeobox 2
AliasesOCT2; OTF2; Oct-2
GeneCards (Weizmann)POU2F2
Ensembl hg19 (Hinxton)ENSG00000028277 [Gene_View]  chr19:42590262-42636625 [Contig_View]  POU2F2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000028277 [Gene_View]  chr19:42590262-42636625 [Contig_View]  POU2F2 [Vega]
ICGC DataPortalENSG00000028277
TCGA cBioPortalPOU2F2
AceView (NCBI)POU2F2
Genatlas (Paris)POU2F2
WikiGenes5452
SOURCE (Princeton)POU2F2
Genomic and cartography
GoldenPath hg19 (UCSC)POU2F2  -     chr19:42590262-42636625 -  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POU2F2  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblPOU2F2 - 19q13.2 [CytoView hg19]  POU2F2 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPOU2F2 [Mapview hg19]  POU2F2 [Mapview hg38]
OMIM164176   
Gene and transcription
Genbank (Entrez)AA832036 BC006101 BF062323 BT007438 CB995118
RefSeq transcript (Entrez)NM_001207025 NM_001207026 NM_001247994 NM_002698
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_030365 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)POU2F2
Cluster EST : UnigeneHs.147381 [ NCBI ]
CGAP (NCI)Hs.147381
Alternative Splicing GalleryENSG00000028277
Gene ExpressionPOU2F2 [ NCBI-GEO ]   POU2F2 [ EBI - ARRAY_EXPRESS ]   POU2F2 [ SEEK ]   POU2F2 [ MEM ]
Gene Expression Viewer (FireBrowse)POU2F2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5452
GTEX Portal (Tissue expression)POU2F2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09086 (Uniprot)
NextProtP09086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09086
Splice isoforms : SwissVarP09086 (Swissvar)
PhosPhoSitePlusP09086
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    Lambda_DNA-bd_dom    POU    POU_dom    TF_octamer   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
DMDM Disease mutations5452
Blocks (Seattle)POU2F2
PDB (SRS)1HDP   
PDB (PDBSum)1HDP   
PDB (IMB)1HDP   
PDB (RSDB)1HDP   
Structural Biology KnowledgeBase1HDP   
SCOP (Structural Classification of Proteins)1HDP   
CATH (Classification of proteins structures)1HDP   
SuperfamilyP09086
Human Protein AtlasENSG00000028277
Peptide AtlasP09086
HPRD01251
IPIIPI00012533   IPI00221055   IPI00335926   IPI00888702   IPI00953226   IPI00383606   IPI00002666   IPI00980009   IPI00976101   IPI01009291   
Protein Interaction databases
DIP (DOE-UCLA)P09086
IntAct (EBI)P09086
FunCoupENSG00000028277
BioGRIDPOU2F2
STRING (EMBL)POU2F2
ZODIACPOU2F2
Ontologies - Pathways
QuickGOP09086
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  mature B cell differentiation  immunoglobulin secretion involved in immune response  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  humoral immune response  protein domain specific binding  snRNA transcription from RNA polymerase II promoter  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  cell maturation  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  mature B cell differentiation  immunoglobulin secretion involved in immune response  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  humoral immune response  protein domain specific binding  snRNA transcription from RNA polymerase II promoter  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  cell maturation  
NDEx Network
Atlas of Cancer Signalling NetworkPOU2F2
Wikipedia pathwaysPOU2F2
Orthology - Evolution
OrthoDB5452
GeneTree (enSembl)ENSG00000028277
Phylogenetic Trees/Animal Genes : TreeFamPOU2F2
Homologs : HomoloGenePOU2F2
Homology/Alignments : Family Browser (UCSC)POU2F2
Gene fusions - Rearrangements
Fusion: TCGAPTPRS 19p13.3 POU2F2 19q13.2 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerPOU2F2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU2F2
dbVarPOU2F2
ClinVarPOU2F2
1000_GenomesPOU2F2 
Exome Variant ServerPOU2F2
ExAC (Exome Aggregation Consortium)POU2F2 (select the gene name)
Genetic variants : HAPMAP5452
Genomic Variants (DGV)POU2F2 [DGVbeta]
Mutations
ICGC Data PortalPOU2F2 
TCGA Data PortalPOU2F2 
Broad Tumor PortalPOU2F2
OASIS PortalPOU2F2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOU2F2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POU2F2
DgiDB (Drug Gene Interaction Database)POU2F2
DoCM (Curated mutations)POU2F2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POU2F2 (select a term)
intoGenPOU2F2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:42590262-42636625  ENSG00000028277
CONAN: Copy Number AnalysisPOU2F2 
Mutations and Diseases : HGMDPOU2F2
OMIM164176   
MedgenPOU2F2
Genetic Testing Registry POU2F2
NextProtP09086 [Medical]
TSGene5452
GENETestsPOU2F2
Huge Navigator POU2F2 [HugePedia]
snp3D : Map Gene to Disease5452
BioCentury BCIQPOU2F2
ClinGenPOU2F2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5452
Chemical/Pharm GKB GenePA33537
Clinical trialPOU2F2
Miscellaneous
canSAR (ICR)POU2F2 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOU2F2
EVEXPOU2F2
GoPubMedPOU2F2
iHOPPOU2F2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:07:27 CEST 2016

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