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POU3F1 (POU class 3 homeobox 1)

Identity

Alias_namesOTF6
POU domain class 3
Alias_symbol (synonym)OCT6
SCIP
Other alias
HGNC (Hugo) POU3F1
LocusID (NCBI) 5453
Atlas_Id 52580
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 38043851 and ends at 38046778 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP11B (3q26.33) / POU3F1 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)POU3F1   9214
Cards
Entrez_Gene (NCBI)POU3F1  5453  POU class 3 homeobox 1
AliasesOCT6; OTF6; SCIP
GeneCards (Weizmann)POU3F1
Ensembl hg19 (Hinxton)ENSG00000185668 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185668 [Gene_View]  chr1:38043851-38046778 [Contig_View]  POU3F1 [Vega]
ICGC DataPortalENSG00000185668
TCGA cBioPortalPOU3F1
AceView (NCBI)POU3F1
Genatlas (Paris)POU3F1
WikiGenes5453
SOURCE (Princeton)POU3F1
Genetics Home Reference (NIH)POU3F1
Genomic and cartography
GoldenPath hg38 (UCSC)POU3F1  -     chr1:38043851-38046778 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POU3F1  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblPOU3F1 - 1p34.3 [CytoView hg19]  POU3F1 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIPOU3F1 [Mapview hg19]  POU3F1 [Mapview hg38]
OMIM602479   
Gene and transcription
Genbank (Entrez)BC156294 L26494 S81257
RefSeq transcript (Entrez)NM_002699
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POU3F1
Cluster EST : UnigeneHs.1837 [ NCBI ]
CGAP (NCI)Hs.1837
Alternative Splicing GalleryENSG00000185668
Gene ExpressionPOU3F1 [ NCBI-GEO ]   POU3F1 [ EBI - ARRAY_EXPRESS ]   POU3F1 [ SEEK ]   POU3F1 [ MEM ]
Gene Expression Viewer (FireBrowse)POU3F1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5453
GTEX Portal (Tissue expression)POU3F1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03052   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03052  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03052
Splice isoforms : SwissVarQ03052
PhosPhoSitePlusQ03052
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Lambda_DNA-bd_dom    POU    POU_dom    TF_POU_3   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
Conserved Domain (NCBI)POU3F1
DMDM Disease mutations5453
Blocks (Seattle)POU3F1
SuperfamilyQ03052
Human Protein AtlasENSG00000185668
Peptide AtlasQ03052
HPRD03921
IPIIPI00008840   
Protein Interaction databases
DIP (DOE-UCLA)Q03052
IntAct (EBI)Q03052
FunCoupENSG00000185668
BioGRIDPOU3F1
STRING (EMBL)POU3F1
ZODIACPOU3F1
Ontologies - Pathways
QuickGOQ03052
Ontology : AmiGORNA polymerase II transcription coactivator activity  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  transcription factor complex  transcription, DNA-templated  axon ensheathment  positive regulation of gene expression  myelination in peripheral nervous system  keratinocyte differentiation  forebrain development  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II transcription coactivator activity  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  transcription factor complex  transcription, DNA-templated  axon ensheathment  positive regulation of gene expression  myelination in peripheral nervous system  keratinocyte differentiation  forebrain development  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkPOU3F1
Atlas of Cancer Signalling NetworkPOU3F1
Wikipedia pathwaysPOU3F1
Orthology - Evolution
OrthoDB5453
GeneTree (enSembl)ENSG00000185668
Phylogenetic Trees/Animal Genes : TreeFamPOU3F1
HOVERGENQ03052
HOGENOMQ03052
Homologs : HomoloGenePOU3F1
Homology/Alignments : Family Browser (UCSC)POU3F1
Gene fusions - Rearrangements
Fusion : MitelmanATP11B/POU3F1 [3q26.33/1p34.3]  [t(1;3)(p34;q26)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOU3F1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU3F1
dbVarPOU3F1
ClinVarPOU3F1
1000_GenomesPOU3F1 
Exome Variant ServerPOU3F1
ExAC (Exome Aggregation Consortium)POU3F1 (select the gene name)
Genetic variants : HAPMAP5453
Genomic Variants (DGV)POU3F1 [DGVbeta]
DECIPHERPOU3F1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOU3F1 
Mutations
ICGC Data PortalPOU3F1 
TCGA Data PortalPOU3F1 
Broad Tumor PortalPOU3F1
OASIS PortalPOU3F1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOU3F1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOU3F1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POU3F1
DgiDB (Drug Gene Interaction Database)POU3F1
DoCM (Curated mutations)POU3F1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POU3F1 (select a term)
intoGenPOU3F1
Cancer3DPOU3F1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602479   
Orphanet
MedgenPOU3F1
Genetic Testing Registry POU3F1
NextProtQ03052 [Medical]
TSGene5453
GENETestsPOU3F1
Huge Navigator POU3F1 [HugePedia]
snp3D : Map Gene to Disease5453
BioCentury BCIQPOU3F1
ClinGenPOU3F1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5453
Chemical/Pharm GKB GenePA33538
Clinical trialPOU3F1
Miscellaneous
canSAR (ICR)POU3F1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOU3F1
EVEXPOU3F1
GoPubMedPOU3F1
iHOPPOU3F1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:32:08 CEST 2017

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