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POU3F3 (POU class 3 homeobox 3)

Identity

Alias_namesPOU domain class 3
Alias_symbol (synonym)BRN1
OTF8
Other aliasbrain-1
oct-8
HGNC (Hugo) POU3F3
LocusID (NCBI) 5455
Atlas_Id 55071
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 104854068 and ends at 104858573 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POU3F3   9216
Cards
Entrez_Gene (NCBI)POU3F3  5455  POU class 3 homeobox 3
AliasesBRN1; OTF8; brain-1; oct-8
GeneCards (Weizmann)POU3F3
Ensembl hg19 (Hinxton)ENSG00000198914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198914 [Gene_View]  chr2:104854068-104858573 [Contig_View]  POU3F3 [Vega]
ICGC DataPortalENSG00000198914
TCGA cBioPortalPOU3F3
AceView (NCBI)POU3F3
Genatlas (Paris)POU3F3
WikiGenes5455
SOURCE (Princeton)POU3F3
Genetics Home Reference (NIH)POU3F3
Genomic and cartography
GoldenPath hg38 (UCSC)POU3F3  -     chr2:104854068-104858573 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POU3F3  -     2q12.1   [Description]    (hg19-Feb_2009)
EnsemblPOU3F3 - 2q12.1 [CytoView hg19]  POU3F3 - 2q12.1 [CytoView hg38]
Mapping of homologs : NCBIPOU3F3 [Mapview hg19]  POU3F3 [Mapview hg38]
OMIM602480   
Gene and transcription
Genbank (Entrez)BC168366 CX873380 CX873394
RefSeq transcript (Entrez)NM_006236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POU3F3
Cluster EST : UnigeneHs.248158 [ NCBI ]
CGAP (NCI)Hs.248158
Alternative Splicing GalleryENSG00000198914
Gene ExpressionPOU3F3 [ NCBI-GEO ]   POU3F3 [ EBI - ARRAY_EXPRESS ]   POU3F3 [ SEEK ]   POU3F3 [ MEM ]
Gene Expression Viewer (FireBrowse)POU3F3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5455
GTEX Portal (Tissue expression)POU3F3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20264   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20264  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20264
Splice isoforms : SwissVarP20264
PhosPhoSitePlusP20264
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Lambda_DNA-bd_dom    POU    POU_dom    TF_POU_3   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
Conserved Domain (NCBI)POU3F3
DMDM Disease mutations5455
Blocks (Seattle)POU3F3
SuperfamilyP20264
Human Protein AtlasENSG00000198914
Peptide AtlasP20264
HPRD03922
IPIIPI00022911   
Protein Interaction databases
DIP (DOE-UCLA)P20264
IntAct (EBI)P20264
FunCoupENSG00000198914
BioGRIDPOU3F3
STRING (EMBL)POU3F3
ZODIACPOU3F3
Ontologies - Pathways
QuickGOP20264
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription, DNA-templated  central nervous system development  excretion  positive regulation of cell proliferation  positive regulation of gene expression  cerebral cortex radially oriented cell migration  forebrain ventricular zone progenitor cell division  negative regulation of apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  chemical homeostasis  HMG box domain binding  metanephric ascending thin limb development  metanephric macula densa development  metanephric thick ascending limb development  metanephric loop of Henle development  metanephric DCT cell differentiation  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription, DNA-templated  central nervous system development  excretion  positive regulation of cell proliferation  positive regulation of gene expression  cerebral cortex radially oriented cell migration  forebrain ventricular zone progenitor cell division  negative regulation of apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  chemical homeostasis  HMG box domain binding  metanephric ascending thin limb development  metanephric macula densa development  metanephric thick ascending limb development  metanephric loop of Henle development  metanephric DCT cell differentiation  
NDEx NetworkPOU3F3
Atlas of Cancer Signalling NetworkPOU3F3
Wikipedia pathwaysPOU3F3
Orthology - Evolution
OrthoDB5455
GeneTree (enSembl)ENSG00000198914
Phylogenetic Trees/Animal Genes : TreeFamPOU3F3
HOVERGENP20264
HOGENOMP20264
Homologs : HomoloGenePOU3F3
Homology/Alignments : Family Browser (UCSC)POU3F3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOU3F3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU3F3
dbVarPOU3F3
ClinVarPOU3F3
1000_GenomesPOU3F3 
Exome Variant ServerPOU3F3
ExAC (Exome Aggregation Consortium)POU3F3 (select the gene name)
Genetic variants : HAPMAP5455
Genomic Variants (DGV)POU3F3 [DGVbeta]
DECIPHERPOU3F3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOU3F3 
Mutations
ICGC Data PortalPOU3F3 
TCGA Data PortalPOU3F3 
Broad Tumor PortalPOU3F3
OASIS PortalPOU3F3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOU3F3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOU3F3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POU3F3
DgiDB (Drug Gene Interaction Database)POU3F3
DoCM (Curated mutations)POU3F3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POU3F3 (select a term)
intoGenPOU3F3
Cancer3DPOU3F3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602480   
Orphanet
MedgenPOU3F3
Genetic Testing Registry POU3F3
NextProtP20264 [Medical]
TSGene5455
GENETestsPOU3F3
Target ValidationPOU3F3
Huge Navigator POU3F3 [HugePedia]
snp3D : Map Gene to Disease5455
BioCentury BCIQPOU3F3
ClinGenPOU3F3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5455
Chemical/Pharm GKB GenePA33540
Clinical trialPOU3F3
Miscellaneous
canSAR (ICR)POU3F3 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOU3F3
EVEXPOU3F3
GoPubMedPOU3F3
iHOPPOU3F3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:25 CEST 2017

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