Atlas of Genetics and Cytogenetics in Oncology and Haematology


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POU4F2 (POU class 4 homeobox 2)

Identity

Alias_namesBRN3B
POU domain, class 4, transcription factor 2
POU domain class 4, transcription factor 2
Alias_symbol (synonym)Brn-3b
Other aliasBRN3.2
HGNC (Hugo) POU4F2
LocusID (NCBI) 5458
Atlas_Id 41788
Location 4q31.22  [Link to chromosome band 4q31]
Location_base_pair Starts at 146638893 and ends at 146642471 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POU4F2   9219
Cards
Entrez_Gene (NCBI)POU4F2  5458  POU class 4 homeobox 2
AliasesBRN3.2; BRN3B; Brn-3b
GeneCards (Weizmann)POU4F2
Ensembl hg19 (Hinxton)ENSG00000151615 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151615 [Gene_View]  chr4:146638893-146642471 [Contig_View]  POU4F2 [Vega]
ICGC DataPortalENSG00000151615
TCGA cBioPortalPOU4F2
AceView (NCBI)POU4F2
Genatlas (Paris)POU4F2
WikiGenes5458
SOURCE (Princeton)POU4F2
Genetics Home Reference (NIH)POU4F2
Genomic and cartography
GoldenPath hg38 (UCSC)POU4F2  -     chr4:146638893-146642471 +  4q31.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POU4F2  -     4q31.22   [Description]    (hg19-Feb_2009)
EnsemblPOU4F2 - 4q31.22 [CytoView hg19]  POU4F2 - 4q31.22 [CytoView hg38]
Mapping of homologs : NCBIPOU4F2 [Mapview hg19]  POU4F2 [Mapview hg38]
OMIM113725   
Gene and transcription
Genbank (Entrez)AK314982 BC136344 BC136345 BY796838 DB082745
RefSeq transcript (Entrez)NM_004575
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POU4F2
Cluster EST : UnigeneHs.266 [ NCBI ]
CGAP (NCI)Hs.266
Alternative Splicing GalleryENSG00000151615
Gene ExpressionPOU4F2 [ NCBI-GEO ]   POU4F2 [ EBI - ARRAY_EXPRESS ]   POU4F2 [ SEEK ]   POU4F2 [ MEM ]
Gene Expression Viewer (FireBrowse)POU4F2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5458
GTEX Portal (Tissue expression)POU4F2
Human Protein AtlasENSG00000151615-POU4F2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12837   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12837  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12837
Splice isoforms : SwissVarQ12837
PhosPhoSitePlusQ12837
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Lambda_DNA-bd_dom    POU    POU_dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
Conserved Domain (NCBI)POU4F2
DMDM Disease mutations5458
Blocks (Seattle)POU4F2
SuperfamilyQ12837
Human Protein Atlas [tissue]ENSG00000151615-POU4F2 [tissue]
Peptide AtlasQ12837
HPRD00220
IPIIPI00029713   
Protein Interaction databases
DIP (DOE-UCLA)Q12837
IntAct (EBI)Q12837
FunCoupENSG00000151615
BioGRIDPOU4F2
STRING (EMBL)POU4F2
ZODIACPOU4F2
Ontologies - Pathways
QuickGOQ12837
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription coactivator activity  transcription corepressor activity  nucleus  nucleus  nucleoplasm  cytoplasm  plasma membrane  transcription from RNA polymerase II promoter  spermatogenesis  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of programmed cell death  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of cell differentiation  positive regulation of cell differentiation  positive regulation of osteoclast differentiation  positive regulation of axon extension  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  regulation of sequence-specific DNA binding transcription factor activity  retina development in camera-type eye  cellular response to cytokine stimulus  cellular response to estradiol stimulus  intrinsic apoptotic signaling pathway by p53 class mediator  regulation of retinal ganglion cell axon guidance  regulation of signal transduction by p53 class mediator  negative regulation of amacrine cell differentiation  dorsal root ganglion development  promoter-specific chromatin binding  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription coactivator activity  transcription corepressor activity  nucleus  nucleus  nucleoplasm  cytoplasm  plasma membrane  transcription from RNA polymerase II promoter  spermatogenesis  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of programmed cell death  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of cell differentiation  positive regulation of cell differentiation  positive regulation of osteoclast differentiation  positive regulation of axon extension  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  regulation of sequence-specific DNA binding transcription factor activity  retina development in camera-type eye  cellular response to cytokine stimulus  cellular response to estradiol stimulus  intrinsic apoptotic signaling pathway by p53 class mediator  regulation of retinal ganglion cell axon guidance  regulation of signal transduction by p53 class mediator  negative regulation of amacrine cell differentiation  dorsal root ganglion development  promoter-specific chromatin binding  positive regulation of transcription regulatory region DNA binding  
NDEx NetworkPOU4F2
Atlas of Cancer Signalling NetworkPOU4F2
Wikipedia pathwaysPOU4F2
Orthology - Evolution
OrthoDB5458
GeneTree (enSembl)ENSG00000151615
Phylogenetic Trees/Animal Genes : TreeFamPOU4F2
HOVERGENQ12837
HOGENOMQ12837
Homologs : HomoloGenePOU4F2
Homology/Alignments : Family Browser (UCSC)POU4F2
Gene fusions - Rearrangements
Fusion: Tumor Portal POU4F2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOU4F2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU4F2
dbVarPOU4F2
ClinVarPOU4F2
1000_GenomesPOU4F2 
Exome Variant ServerPOU4F2
ExAC (Exome Aggregation Consortium)ENSG00000151615
GNOMAD BrowserENSG00000151615
Genetic variants : HAPMAP5458
Genomic Variants (DGV)POU4F2 [DGVbeta]
DECIPHERPOU4F2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOU4F2 
Mutations
ICGC Data PortalPOU4F2 
TCGA Data PortalPOU4F2 
Broad Tumor PortalPOU4F2
OASIS PortalPOU4F2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOU4F2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOU4F2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch POU4F2
DgiDB (Drug Gene Interaction Database)POU4F2
DoCM (Curated mutations)POU4F2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POU4F2 (select a term)
intoGenPOU4F2
Cancer3DPOU4F2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113725   
Orphanet
MedgenPOU4F2
Genetic Testing Registry POU4F2
NextProtQ12837 [Medical]
TSGene5458
GENETestsPOU4F2
Target ValidationPOU4F2
Huge Navigator POU4F2 [HugePedia]
snp3D : Map Gene to Disease5458
BioCentury BCIQPOU4F2
ClinGenPOU4F2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5458
Chemical/Pharm GKB GenePA33543
Clinical trialPOU4F2
Miscellaneous
canSAR (ICR)POU4F2 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOU4F2
EVEXPOU4F2
GoPubMedPOU4F2
iHOPPOU4F2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:06:01 CET 2017

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