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POU4F2 (POU class 4 homeobox 2)

Identity

Other namesBRN3.2
BRN3B
Brn-3b
HGNC (Hugo) POU4F2
LocusID (NCBI) 5458
Location 4q31.22
Location_base_pair Starts at 147560045 and ends at 147563623 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)POU4F2   9219
Entrez_Gene (NCBI)POU4F2  5458  POU class 4 homeobox 2
Cards
GeneCards (Weizmann)POU4F2
Ensembl (Hinxton)ENSG00000151615 [Gene_View]  chr4:147560045-147563623 [Contig_View]  POU4F2 [Vega]
AceView (NCBI)POU4F2
Genatlas (Paris)POU4F2
SOURCE (Stanford)NM_004575
Genomic and cartography
GoldenPath (UCSC)POU4F2  -  4q31.22   chr4:147560045-147563623 +  4q31.22   [Description]    (hg19-Feb_2009)
EnsemblPOU4F2 - 4q31.22 [CytoView]
Mapping of homologs : NCBIPOU4F2 [Mapview]
OMIM113725   
Gene and transcription
Genbank (Entrez)AK314982 BC136344 BC136345 BY796838 DB082745
RefSeq transcript (SRS)NM_004575
RefSeq transcript (Entrez)NM_004575
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838921 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838921 NW_004078021
Consensus coding sequences : CCDS (NCBI)POU4F2
Cluster EST : UnigeneHs.266 [ SRS ] Hs.266 [ NCBI ]
CGAP (NCI)Hs.266
Alternative Splicing : Fast-db (Paris)GSHG0022897
Alternative Splicing GalleryENSG00000151615
Gene ExpressionPOU4F2 [ NCBI-GEO ]   POU4F2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12837 (SRS) Q12837 (Uniprot)
NextProtQ12837
With graphics : InterProQ12837
Splice isoforms : SwissVarQ12837(Swissvar)
Domaine pattern : Prosite (SRS)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (SRS)Homeobox_CS    Homeodomain    Homeodomain-like    Lambda_DNA-bd_dom    POU    POU_specific   
Domains : Interpro (EBI)Homeobox_CS    Homeodomain    Homeodomain-like    Lambda_DNA-bd_dom    POU    POU_specific   
Related proteins : CluSTrQ12837
Domain families : Pfam (SRS)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
DMDM5458
Blocks (Seattle)Q12837
Human Protein AtlasENSG00000151615
HPRD00220
IPIIPI00029713   
Protein Interaction databases
DIP (DOE-UCLA)Q12837
IntAct (EBI)Q12837
FunCoupENSG00000151615
REACTOMEPOU4F2
Protein Interaction Database5458
BioGRIDPOU4F2
InParanoidQ12837
Interologous Interaction database Q12837
IntegromeDBPOU4F2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)POU4F2
SNP (GeneSNP Utah)POU4F2
SNP : HGBasePOU4F2
Genetic variants : HAPMAPPOU4F2
Somatic Mutations in Cancer : COSMICPOU4F2 
CONAN: Copy Number AnalysisPOU4F2 
Mutations and Diseases : HGMDPOU4F2
OMIM113725   
GENETests113725   
Disease Genetic AssociationPOU4F2
Huge Navigator POU4F2 [HugePedia]  POU4F2 [HugeCancerGEM]
Genomic VariantsPOU4F2  POU4F2 [DGVbeta]
snp3D : Map Gene to Disease5458
General knowledge
Homologs : HomoloGenePOU4F2
Homology/Alignments : Family Browser (UCSC)POU4F2
Phylogenetic Trees/Animal Genes : TreeFamPOU4F2
Chemical/Protein Interactions : CTD5458
Chemical/Pharm GKB GenePA33543
Clinical trialPOU4F2
Cancer Resource (Charite)ENSG00000151615
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  chromatin binding  nucleus  nucleus  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension involved in development  neuromuscular process controlling balance  retina development in camera-type eye  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  chromatin binding  nucleus  nucleus  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension involved in development  neuromuscular process controlling balance  retina development in camera-type eye  
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
PubGenePOU4F2
iHOPPOU4F2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:32:30 CEST 2013
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