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POU4F2 (POU class 4 homeobox 2)

Identity

Other namesBRN3.2
BRN3B
Brn-3b
HGNC (Hugo) POU4F2
LocusID (NCBI) 5458
Location 4q31.22
Location_base_pair Starts at 147560045 and ends at 147563623 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)POU4F2   9219
Cards
Entrez_Gene (NCBI)POU4F2  5458  POU class 4 homeobox 2
GeneCards (Weizmann)POU4F2
Ensembl hg19 (Hinxton)ENSG00000151615 [Gene_View]  chr4:147560045-147563623 [Contig_View]  POU4F2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000151615 [Gene_View]  chr4:147560045-147563623 [Contig_View]  POU4F2 [Vega]
ICGC DataPortalENSG00000151615
cBioPortalPOU4F2
AceView (NCBI)POU4F2
Genatlas (Paris)POU4F2
WikiGenes5458
SOURCE (Princeton)POU4F2
Genomic and cartography
GoldenPath hg19 (UCSC)POU4F2  -     chr4:147560045-147563623 +  4q31.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)POU4F2  -     4q31.22   [Description]    (hg38-Dec_2013)
EnsemblPOU4F2 - 4q31.22 [CytoView hg19]  POU4F2 - 4q31.22 [CytoView hg38]
Mapping of homologs : NCBIPOU4F2 [Mapview hg19]  POU4F2 [Mapview hg38]
OMIM113725   
Gene and transcription
Genbank (Entrez)AK314982 BC136344 BC136345 BY796838 DB082745
RefSeq transcript (Entrez)NM_004575
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838921 NW_004929320
Consensus coding sequences : CCDS (NCBI)POU4F2
Cluster EST : UnigeneHs.266 [ NCBI ]
CGAP (NCI)Hs.266
Alternative Splicing : Fast-db (Paris)GSHG0022897
Alternative Splicing GalleryENSG00000151615
Gene ExpressionPOU4F2 [ NCBI-GEO ]     POU4F2 [ SEEK ]   POU4F2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12837 (Uniprot)
NextProtQ12837  [Medical]
With graphics : InterProQ12837
Splice isoforms : SwissVarQ12837 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    Lambda_DNA-bd_dom    POU    POU_specific   
Related proteins : CluSTrQ12837
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
DMDM Disease mutations5458
Blocks (Seattle)Q12837
Human Protein AtlasENSG00000151615
Peptide AtlasQ12837
HPRD00220
IPIIPI00029713   
Protein Interaction databases
DIP (DOE-UCLA)Q12837
IntAct (EBI)Q12837
FunCoupENSG00000151615
BioGRIDPOU4F2
IntegromeDBPOU4F2
STRING (EMBL)POU4F2
Ontologies - Pathways
QuickGOQ12837
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  chromatin binding  nucleus  nucleus  transcription, DNA-templated  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  retina development in camera-type eye  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  chromatin binding  nucleus  nucleus  transcription, DNA-templated  axon guidance  sensory perception of sound  nuclear speck  neuron differentiation  intracellular estrogen receptor signaling pathway  retinal ganglion cell axon guidance  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  retina development in camera-type eye  
Protein Interaction DatabasePOU4F2
DoCM (Curated mutations)POU4F2
Wikipedia pathwaysPOU4F2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPOU4F2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU4F2
dbVarPOU4F2
ClinVarPOU4F2
1000_GenomesPOU4F2 
Exome Variant ServerPOU4F2
SNP (GeneSNP Utah)POU4F2
SNP : HGBasePOU4F2
Genetic variants : HAPMAPPOU4F2
Genomic VariantsPOU4F2  POU4F2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000151615 
Somatic Mutations in Cancer : COSMICPOU4F2 
CONAN: Copy Number AnalysisPOU4F2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:147560045-147563623
Mutations and Diseases : HGMDPOU4F2
OMIM113725   
MedgenPOU4F2
NextProtQ12837 [Medical]
GENETestsPOU4F2
Disease Genetic AssociationPOU4F2
Huge Navigator POU4F2 [HugePedia]  POU4F2 [HugeCancerGEM]
snp3D : Map Gene to Disease5458
DGIdb (Drug Gene Interaction db)POU4F2
General knowledge
Homologs : HomoloGenePOU4F2
Homology/Alignments : Family Browser (UCSC)POU4F2
Phylogenetic Trees/Animal Genes : TreeFamPOU4F2
Chemical/Protein Interactions : CTD5458
Chemical/Pharm GKB GenePA33543
Clinical trialPOU4F2
Cancer Resource (Charite)ENSG00000151615
Other databases
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
CoreMinePOU4F2
GoPubMedPOU4F2
iHOPPOU4F2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:54:53 CET 2014

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