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POU4F3 (POU class 4 homeobox 3)

Identity

Alias_namesDFNA15
POU domain class 4
Alias_symbol (synonym)BRN3C
Other aliasDFNA42
DFNA52
HGNC (Hugo) POU4F3
LocusID (NCBI) 5459
Atlas_Id 46553
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 146339024 and ends at 146340520 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)POU4F3   9220
Cards
Entrez_Gene (NCBI)POU4F3  5459  POU class 4 homeobox 3
AliasesBRN3C; DFNA15; DFNA42; DFNA52
GeneCards (Weizmann)POU4F3
Ensembl hg19 (Hinxton)ENSG00000091010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091010 [Gene_View]  chr5:146339024-146340520 [Contig_View]  POU4F3 [Vega]
ICGC DataPortalENSG00000091010
TCGA cBioPortalPOU4F3
AceView (NCBI)POU4F3
Genatlas (Paris)POU4F3
WikiGenes5459
SOURCE (Princeton)POU4F3
Genetics Home Reference (NIH)POU4F3
Genomic and cartography
GoldenPath hg38 (UCSC)POU4F3  -     chr5:146339024-146340520 +  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POU4F3  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblPOU4F3 - 5q32 [CytoView hg19]  POU4F3 - 5q32 [CytoView hg38]
Mapping of homologs : NCBIPOU4F3 [Mapview hg19]  POU4F3 [Mapview hg38]
OMIM602459   602460   
Gene and transcription
Genbank (Entrez)BC104923 BC112207 EU446649 HQ258176
RefSeq transcript (Entrez)NM_002700
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POU4F3
Cluster EST : UnigeneHs.553499 [ NCBI ]
CGAP (NCI)Hs.553499
Alternative Splicing GalleryENSG00000091010
Gene ExpressionPOU4F3 [ NCBI-GEO ]   POU4F3 [ EBI - ARRAY_EXPRESS ]   POU4F3 [ SEEK ]   POU4F3 [ MEM ]
Gene Expression Viewer (FireBrowse)POU4F3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5459
GTEX Portal (Tissue expression)POU4F3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15319   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15319  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15319
Splice isoforms : SwissVarQ15319
PhosPhoSitePlusQ15319
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    POU_1 (PS00035)    POU_2 (PS00465)    POU_3 (PS51179)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Lambda_DNA-bd_dom    POU    POU4F3    POU_dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    Pou (PF00157)   
Domain families : Pfam (NCBI)pfam00046    pfam00157   
Domain families : Smart (EMBL)HOX (SM00389)  POU (SM00352)  
Conserved Domain (NCBI)POU4F3
DMDM Disease mutations5459
Blocks (Seattle)POU4F3
SuperfamilyQ15319
Human Protein AtlasENSG00000091010
Peptide AtlasQ15319
HPRD03911
IPIIPI00016424   
Protein Interaction databases
DIP (DOE-UCLA)Q15319
IntAct (EBI)Q15319
FunCoupENSG00000091010
BioGRIDPOU4F3
STRING (EMBL)POU4F3
ZODIACPOU4F3
Ontologies - Pathways
QuickGOQ15319
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  nucleoplasm  transcription from RNA polymerase II promoter  visual perception  sensory perception of sound  vestibulocochlear nerve development  retinal ganglion cell axon guidance  inner ear morphogenesis  auditory receptor cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  neuron apoptotic process  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  nucleoplasm  transcription from RNA polymerase II promoter  visual perception  sensory perception of sound  vestibulocochlear nerve development  retinal ganglion cell axon guidance  inner ear morphogenesis  auditory receptor cell differentiation  positive regulation of transcription from RNA polymerase II promoter  axon extension  neuromuscular process controlling balance  neuron apoptotic process  
NDEx NetworkPOU4F3
Atlas of Cancer Signalling NetworkPOU4F3
Wikipedia pathwaysPOU4F3
Orthology - Evolution
OrthoDB5459
GeneTree (enSembl)ENSG00000091010
Phylogenetic Trees/Animal Genes : TreeFamPOU4F3
HOVERGENQ15319
HOGENOMQ15319
Homologs : HomoloGenePOU4F3
Homology/Alignments : Family Browser (UCSC)POU4F3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOU4F3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)POU4F3
dbVarPOU4F3
ClinVarPOU4F3
1000_GenomesPOU4F3 
Exome Variant ServerPOU4F3
ExAC (Exome Aggregation Consortium)POU4F3 (select the gene name)
Genetic variants : HAPMAP5459
Genomic Variants (DGV)POU4F3 [DGVbeta]
DECIPHERPOU4F3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOU4F3 
Mutations
ICGC Data PortalPOU4F3 
TCGA Data PortalPOU4F3 
Broad Tumor PortalPOU4F3
OASIS PortalPOU4F3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOU4F3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPOU4F3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch POU4F3
DgiDB (Drug Gene Interaction Database)POU4F3
DoCM (Curated mutations)POU4F3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POU4F3 (select a term)
intoGenPOU4F3
Cancer3DPOU4F3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602459    602460   
Orphanet12046   
MedgenPOU4F3
Genetic Testing Registry POU4F3
NextProtQ15319 [Medical]
TSGene5459
GENETestsPOU4F3
Target ValidationPOU4F3
Huge Navigator POU4F3 [HugePedia]
snp3D : Map Gene to Disease5459
BioCentury BCIQPOU4F3
ClinGenPOU4F3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5459
Chemical/Pharm GKB GenePA33544
Clinical trialPOU4F3
Miscellaneous
canSAR (ICR)POU4F3 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOU4F3
EVEXPOU4F3
GoPubMedPOU4F3
iHOPPOU4F3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:03:57 CEST 2017

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