POU5F1B (POU class 5 homeobox 1B)

2010-05-01  

Identity

HGNC
LOCATION
8q24.21
LOCUSID
ALIAS
OCT4-PG1,OCT4PG1,OTF3C,OTF3P1,POU5F1P1,POU5F1P4,POU5FLC20,POU5FLC8

Other Information

Locus ID:

NCBI: 5462
MIM: 615739
HGNC: 9223
Ensembl: ENSG00000212993

Variants:

dbSNP: 5462
ClinVar: 5462
TCGA: ENSG00000212993
COSMIC: POU5F1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000212993ENST00000465342Q06416
ENSG00000212993ENST00000645438Q06416

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550

References

Pubmed IDYearTitleCitations
243625232015The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer.47
189493972008The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.30
200171642010POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma.28
195627292009Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.25
230642892013A diabetic milieu promotes OCT4 and NANOG production in human visceral-derived adipose stem cells.12
243384222013Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.11
250467482014Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.11
201583062010Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.8
294542852018POU5F1B promotes hepatocellular carcinoma proliferation by activating AKT.6
307620282019The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is Upregulated in Cervical Cancer and Down-Regulation Inhibits Cell Proliferation and Migration and Induces Apoptosis in Cervical Cancer Cell Lines.4

Citation

Dessen P

POU5F1B (POU class 5 homeobox 1B)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51472/pou5f1b