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PPA1 (inorganic pyrophosphatase 1)

Identity

Alias (NCBI)HEL-S-66p
IOPPP
PP
PP1
SID6-8061
HGNC (Hugo) PPA1
HGNC Alias symbSID6-8061
Ppase
IOPPP
PP1
HGNC Alias namecytosolic inorganic pyrophosphatase
 inorganic pyrophosphatase 1
 pyrophosphate phospho-hydrolase
 inorganic diphosphatase 1
HGNC Previous namePP
HGNC Previous namepyrophosphatase (inorganic)
 pyrophosphatase (inorganic) 1
LocusID (NCBI) 5464
Atlas_Id 53182
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70202836 and ends at 70233429 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPA1 (10q22.1) / DSP (6p24.3)PPA1 (10q22.1) / TMEM50B (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPA1   9226
Cards
Entrez_Gene (NCBI)PPA1    inorganic pyrophosphatase 1
AliasesHEL-S-66p; IOPPP; PP; PP1; 
SID6-8061
GeneCards (Weizmann)PPA1
Ensembl hg19 (Hinxton)ENSG00000180817 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180817 [Gene_View]  ENSG00000180817 [Sequence]  chr10:70202836-70233429 [Contig_View]  PPA1 [Vega]
ICGC DataPortalENSG00000180817
TCGA cBioPortalPPA1
AceView (NCBI)PPA1
Genatlas (Paris)PPA1
SOURCE (Princeton)PPA1
Genetics Home Reference (NIH)PPA1
Genomic and cartography
GoldenPath hg38 (UCSC)PPA1  -     chr10:70202836-70233429 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPA1  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathPPA1 - 10q22.1 [CytoView hg19]  PPA1 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000180817
Genome Data Viewer NCBIPPA1 [Mapview hg19]  
OMIM179030   
Gene and transcription
Genbank (Entrez)AB026723 AF092439 AF108211 AF119665 AF154065
RefSeq transcript (Entrez)NM_021129
Consensus coding sequences : CCDS (NCBI)PPA1
Gene ExpressionPPA1 [ NCBI-GEO ]   PPA1 [ EBI - ARRAY_EXPRESS ]   PPA1 [ SEEK ]   PPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPA1 [ Firebrowse - Broad ]
GenevisibleExpression of PPA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5464
GTEX Portal (Tissue expression)PPA1
Human Protein AtlasENSG00000180817-PPA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15181
Catalytic activity : Enzyme3.6.1.1 [ Enzyme-Expasy ]   3.6.1.13.6.1.1 [ IntEnz-EBI ]   3.6.1.1 [ BRENDA ]   3.6.1.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15181
Domaine pattern : Prosite (Expaxy)PPASE (PS00387)   
Domains : Interpro (EBI)Pyrophosphatase    Pyrophosphatase_sf   
Domain families : Pfam (Sanger)Pyrophosphatase (PF00719)   
Domain families : Pfam (NCBI)pfam00719   
Conserved Domain (NCBI)PPA1
PDB (RSDB)6C45    7BTN    7CMO   
PDB Europe6C45    7BTN    7CMO   
PDB (PDBSum)6C45    7BTN    7CMO   
PDB (IMB)6C45    7BTN    7CMO   
Structural Biology KnowledgeBase6C45    7BTN    7CMO   
SCOP (Structural Classification of Proteins)6C45    7BTN    7CMO   
CATH (Classification of proteins structures)6C45    7BTN    7CMO   
SuperfamilyQ15181
AlphaFold pdb e-kbQ15181   
Human Protein Atlas [tissue]ENSG00000180817-PPA1 [tissue]
HPRD01527
Protein Interaction databases
DIP (DOE-UCLA)Q15181
IntAct (EBI)Q15181
BioGRIDPPA1
STRING (EMBL)PPA1
ZODIACPPA1
Ontologies - Pathways
QuickGOQ15181
Ontology : AmiGOmagnesium ion binding  inorganic diphosphatase activity  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  phosphate-containing compound metabolic process  extracellular exosome  diphosphate metabolic process  
Ontology : EGO-EBImagnesium ion binding  inorganic diphosphatase activity  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  phosphate-containing compound metabolic process  extracellular exosome  diphosphate metabolic process  
Pathways : KEGGOxidative phosphorylation   
NDEx NetworkPPA1
Atlas of Cancer Signalling NetworkPPA1
Wikipedia pathwaysPPA1
Orthology - Evolution
OrthoDB5464
GeneTree (enSembl)ENSG00000180817
Phylogenetic Trees/Animal Genes : TreeFamPPA1
Homologs : HomoloGenePPA1
Homology/Alignments : Family Browser (UCSC)PPA1
Gene fusions - Rearrangements
Fusion : QuiverPPA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPA1
dbVarPPA1
ClinVarPPA1
MonarchPPA1
1000_GenomesPPA1 
Exome Variant ServerPPA1
GNOMAD BrowserENSG00000180817
Varsome BrowserPPA1
ACMGPPA1 variants
VarityQ15181
Genomic Variants (DGV)PPA1 [DGVbeta]
DECIPHERPPA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPA1 
Mutations
ICGC Data PortalPPA1 
TCGA Data PortalPPA1 
Broad Tumor PortalPPA1
OASIS PortalPPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPA1
Mutations and Diseases : HGMDPPA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPA1
DgiDB (Drug Gene Interaction Database)PPA1
DoCM (Curated mutations)PPA1
CIViC (Clinical Interpretations of Variants in Cancer)PPA1
Cancer3DPPA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179030   
Orphanet
DisGeNETPPA1
MedgenPPA1
Genetic Testing Registry PPA1
NextProtQ15181 [Medical]
GENETestsPPA1
Target ValidationPPA1
Huge Navigator PPA1 [HugePedia]
ClinGenPPA1
Clinical trials, drugs, therapy
MyCancerGenomePPA1
Protein Interactions : CTDPPA1
Pharm GKB GenePA33550
PharosQ15181
Clinical trialPPA1
Miscellaneous
canSAR (ICR)PPA1
HarmonizomePPA1
DataMed IndexPPA1
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:16 CEST 2021

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