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PPA1 (pyrophosphatase (inorganic) 1)

Identity

Alias_namesPP
pyrophosphatase (inorganic)
Alias_symbol (synonym)SID6-8061
Ppase
IOPPP
PP1
Other aliasHEL-S-66p
HGNC (Hugo) PPA1
LocusID (NCBI) 5464
Atlas_Id 53182
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70202830 and ends at 70233434 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPA1 (10q22.1) / DSP (6p24.3)PPA1 (10q22.1) / TMEM50B (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPA1   9226
Cards
Entrez_Gene (NCBI)PPA1  5464  pyrophosphatase (inorganic) 1
AliasesHEL-S-66p; IOPPP; PP; PP1; 
SID6-8061
GeneCards (Weizmann)PPA1
Ensembl hg19 (Hinxton)ENSG00000180817 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180817 [Gene_View]  chr10:70202830-70233434 [Contig_View]  PPA1 [Vega]
ICGC DataPortalENSG00000180817
TCGA cBioPortalPPA1
AceView (NCBI)PPA1
Genatlas (Paris)PPA1
WikiGenes5464
SOURCE (Princeton)PPA1
Genetics Home Reference (NIH)PPA1
Genomic and cartography
GoldenPath hg38 (UCSC)PPA1  -     chr10:70202830-70233434 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPA1  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblPPA1 - 10q22.1 [CytoView hg19]  PPA1 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIPPA1 [Mapview hg19]  PPA1 [Mapview hg38]
OMIM179030   
Gene and transcription
Genbank (Entrez)AB026723 AF092439 AF108211 AF119665 AF154065
RefSeq transcript (Entrez)NM_021129
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPA1
Cluster EST : UnigeneHs.437403 [ NCBI ]
CGAP (NCI)Hs.437403
Alternative Splicing GalleryENSG00000180817
Gene ExpressionPPA1 [ NCBI-GEO ]   PPA1 [ EBI - ARRAY_EXPRESS ]   PPA1 [ SEEK ]   PPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5464
GTEX Portal (Tissue expression)PPA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15181
Splice isoforms : SwissVarQ15181
Catalytic activity : Enzyme3.6.1.1 [ Enzyme-Expasy ]   3.6.1.13.6.1.1 [ IntEnz-EBI ]   3.6.1.1 [ BRENDA ]   3.6.1.1 [ KEGG ]   
PhosPhoSitePlusQ15181
Domaine pattern : Prosite (Expaxy)PPASE (PS00387)   
Domains : Interpro (EBI)Pyrophosphatase   
Domain families : Pfam (Sanger)Pyrophosphatase (PF00719)   
Domain families : Pfam (NCBI)pfam00719   
Conserved Domain (NCBI)PPA1
DMDM Disease mutations5464
Blocks (Seattle)PPA1
SuperfamilyQ15181
Human Protein AtlasENSG00000180817
Peptide AtlasQ15181
HPRD01527
IPIIPI00015018   IPI00643288   
Protein Interaction databases
DIP (DOE-UCLA)Q15181
IntAct (EBI)Q15181
FunCoupENSG00000180817
BioGRIDPPA1
STRING (EMBL)PPA1
ZODIACPPA1
Ontologies - Pathways
QuickGOQ15181
Ontology : AmiGOmagnesium ion binding  inorganic diphosphatase activity  cytoplasm  cytosol  tRNA aminoacylation for protein translation  phosphate-containing compound metabolic process  extracellular exosome  diphosphate metabolic process  
Ontology : EGO-EBImagnesium ion binding  inorganic diphosphatase activity  cytoplasm  cytosol  tRNA aminoacylation for protein translation  phosphate-containing compound metabolic process  extracellular exosome  diphosphate metabolic process  
Pathways : KEGGOxidative phosphorylation   
NDEx NetworkPPA1
Atlas of Cancer Signalling NetworkPPA1
Wikipedia pathwaysPPA1
Orthology - Evolution
OrthoDB5464
GeneTree (enSembl)ENSG00000180817
Phylogenetic Trees/Animal Genes : TreeFamPPA1
HOVERGENQ15181
HOGENOMQ15181
Homologs : HomoloGenePPA1
Homology/Alignments : Family Browser (UCSC)PPA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPA1
dbVarPPA1
ClinVarPPA1
1000_GenomesPPA1 
Exome Variant ServerPPA1
ExAC (Exome Aggregation Consortium)PPA1 (select the gene name)
Genetic variants : HAPMAP5464
Genomic Variants (DGV)PPA1 [DGVbeta]
DECIPHERPPA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPA1 
Mutations
ICGC Data PortalPPA1 
TCGA Data PortalPPA1 
Broad Tumor PortalPPA1
OASIS PortalPPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPA1
DgiDB (Drug Gene Interaction Database)PPA1
DoCM (Curated mutations)PPA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPA1 (select a term)
intoGenPPA1
Cancer3DPPA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179030   
Orphanet
MedgenPPA1
Genetic Testing Registry PPA1
NextProtQ15181 [Medical]
TSGene5464
GENETestsPPA1
Target ValidationPPA1
Huge Navigator PPA1 [HugePedia]
snp3D : Map Gene to Disease5464
BioCentury BCIQPPA1
ClinGenPPA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5464
Chemical/Pharm GKB GenePA33550
Clinical trialPPA1
Miscellaneous
canSAR (ICR)PPA1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPA1
EVEXPPA1
GoPubMedPPA1
iHOPPPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:49 CEST 2017

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