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PPA2 (pyrophosphatase (inorganic) 2)

Identity

Alias_symbol (synonym)FLJ20459
Other aliasHSPC124
SID6-306
HGNC (Hugo) PPA2
LocusID (NCBI) 27068
Atlas_Id 56151
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 106290234 and ends at 106395227 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
REV3L (6q21) / PPA2 (4q24)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPA2   28883
Cards
Entrez_Gene (NCBI)PPA2  27068  pyrophosphatase (inorganic) 2
AliasesHSPC124; SID6-306
GeneCards (Weizmann)PPA2
Ensembl hg19 (Hinxton)ENSG00000138777 [Gene_View]  chr4:106290234-106395227 [Contig_View]  PPA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138777 [Gene_View]  chr4:106290234-106395227 [Contig_View]  PPA2 [Vega]
ICGC DataPortalENSG00000138777
TCGA cBioPortalPPA2
AceView (NCBI)PPA2
Genatlas (Paris)PPA2
WikiGenes27068
SOURCE (Princeton)PPA2
Genetics Home Reference (NIH)PPA2
Genomic and cartography
GoldenPath hg19 (UCSC)PPA2  -     chr4:106290234-106395227 -  4q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPA2  -     4q24   [Description]    (hg38-Dec_2013)
EnsemblPPA2 - 4q24 [CytoView hg19]  PPA2 - 4q24 [CytoView hg38]
Mapping of homologs : NCBIPPA2 [Mapview hg19]  PPA2 [Mapview hg38]
OMIM609988   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001034191 NM_001034192 NM_001034193 NM_006903 NM_176866 NM_176867 NM_176869
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPA2
Cluster EST : UnigeneHs.654957 [ NCBI ]
CGAP (NCI)Hs.654957
Alternative Splicing GalleryENSG00000138777
Gene ExpressionPPA2 [ NCBI-GEO ]   PPA2 [ EBI - ARRAY_EXPRESS ]   PPA2 [ SEEK ]   PPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PPA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27068
GTEX Portal (Tissue expression)PPA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2U2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2U2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2U2
Splice isoforms : SwissVarQ9H2U2
Catalytic activity : Enzyme3.6.1.1 [ Enzyme-Expasy ]   3.6.1.13.6.1.1 [ IntEnz-EBI ]   3.6.1.1 [ BRENDA ]   3.6.1.1 [ KEGG ]   
PhosPhoSitePlusQ9H2U2
Domaine pattern : Prosite (Expaxy)PPASE (PS00387)   
Domains : Interpro (EBI)Pyrophosphatase   
Domain families : Pfam (Sanger)Pyrophosphatase (PF00719)   
Domain families : Pfam (NCBI)pfam00719   
Conserved Domain (NCBI)PPA2
DMDM Disease mutations27068
Blocks (Seattle)PPA2
SuperfamilyQ9H2U2
Human Protein AtlasENSG00000138777
Peptide AtlasQ9H2U2
HPRD18494
IPIIPI00301109   IPI00470502   IPI00470503   IPI00470504   IPI00910509   IPI00654717   IPI00966045   IPI00413014   IPI00967986   IPI00966339   IPI00967911   IPI00966931   IPI00968235   IPI00966589   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2U2
IntAct (EBI)Q9H2U2
FunCoupENSG00000138777
BioGRIDPPA2
STRING (EMBL)PPA2
ZODIACPPA2
Ontologies - Pathways
QuickGOQ9H2U2
Ontology : AmiGOmagnesium ion binding  inorganic diphosphatase activity  protein serine/threonine phosphatase activity  mitochondrial matrix  tRNA aminoacylation for protein translation  protein dephosphorylation  extracellular exosome  diphosphate metabolic process  
Ontology : EGO-EBImagnesium ion binding  inorganic diphosphatase activity  protein serine/threonine phosphatase activity  mitochondrial matrix  tRNA aminoacylation for protein translation  protein dephosphorylation  extracellular exosome  diphosphate metabolic process  
Pathways : KEGGOxidative phosphorylation   
NDEx NetworkPPA2
Atlas of Cancer Signalling NetworkPPA2
Wikipedia pathwaysPPA2
Orthology - Evolution
OrthoDB27068
GeneTree (enSembl)ENSG00000138777
Phylogenetic Trees/Animal Genes : TreeFamPPA2
HOVERGENQ9H2U2
HOGENOMQ9H2U2
Homologs : HomoloGenePPA2
Homology/Alignments : Family Browser (UCSC)PPA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPA2
dbVarPPA2
ClinVarPPA2
1000_GenomesPPA2 
Exome Variant ServerPPA2
ExAC (Exome Aggregation Consortium)PPA2 (select the gene name)
Genetic variants : HAPMAP27068
Genomic Variants (DGV)PPA2 [DGVbeta]
DECIPHER (Syndromes)4:106290234-106395227  ENSG00000138777
CONAN: Copy Number AnalysisPPA2 
Mutations
ICGC Data PortalPPA2 
TCGA Data PortalPPA2 
Broad Tumor PortalPPA2
OASIS PortalPPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PPA2
DgiDB (Drug Gene Interaction Database)PPA2
DoCM (Curated mutations)PPA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPA2 (select a term)
intoGenPPA2
Cancer3DPPA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609988   
Orphanet
MedgenPPA2
Genetic Testing Registry PPA2
NextProtQ9H2U2 [Medical]
TSGene27068
GENETestsPPA2
Huge Navigator PPA2 [HugePedia]
snp3D : Map Gene to Disease27068
BioCentury BCIQPPA2
ClinGenPPA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27068
Chemical/Pharm GKB GenePA142671159
Clinical trialPPA2
Miscellaneous
canSAR (ICR)PPA2 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPA2
EVEXPPA2
GoPubMedPPA2
iHOPPPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:22:20 CET 2017

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